Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Douglas M Heuman"'
Autor:
Jasmohan S Bajaj, Sili Fan, Leroy R Thacker, Andrew Fagan, Edith Gavis, Melanie B White, Douglas M Heuman, Michael Fuchs, Oliver Fiehn
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0223061 (2019)
BackgroundCirrhosis can alter several metabolic pathways. Metabolomics could prognosticate outcomes like hepatic encephalopathy (HE), transplant, hospitalization and death.AimDetermine changes in serum and urine metabolomics in cirrhotics who develop
Externí odkaz:
https://doaj.org/article/9cc9f4bc7ba146d28bff0c015688790d
Autor:
Jasmohan S Bajaj, Douglas M Heuman, Arun J Sanyal, Phillip B Hylemon, Richard K Sterling, R Todd Stravitz, Michael Fuchs, Jason M Ridlon, Kalyani Daita, Pamela Monteith, Nicole A Noble, Melanie B White, Andmorgan Fisher, Masoumeh Sikaroodi, Huzefa Rangwala, Patrick M Gillevet
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60042 (2013)
Hepatic encephalopathy (HE) represents a dysfunctional gut-liver-brain axis in cirrhosis which can negatively impact outcomes. This altered gut-brain relationship has been treated using gut-selective antibiotics such as rifaximin, that improve cognit
Externí odkaz:
https://doaj.org/article/45dc96f92b3e4866b15094e7e2c6d7f9
Autor:
Douglas M. Heuman, Patrick M. Gillevet, Andrew Fagan, Melanie B. White, Edith Gavis, Ravishankar K. Iyer, Krishnakant Saboo, Mihir V. Iyer, Jasmohan S. Bajaj, Michael Fuchs, Masoumeh Sikaroodi, Amirhossein Shamsaddini, Chang Hu
Publikováno v:
J Hepatol
Background & Aims Altered microbiota can affect the gut-liver-brain axis in cirrhosis and hepatic encephalopathy (HE), but the impact of sex on these changes is unclear. We aimed to determine differences in fecal microbiota composition/functionality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76cfd67ddd94648be274609ed5fe8fb
https://doi.org/10.1016/j.jhep.2020.06.046
https://doi.org/10.1016/j.jhep.2020.06.046
Autor:
Felicia Tinsley, Melanie B. White, Leroy R. Thacker, James B. Wade, Jasmohan S. Bajaj, Velimir A. Luketic, Hannah Lee, Douglas M. Heuman, Chathur Acharya, Puneet Puri, Arun J. Sanyal, Andrew Fagan, Scott Matherly, Mohammad S. Siddiqui, Michael Fuchs, R. Todd Stravitz, Richard K. Sterling, HoChong Gilles
Publikováno v:
Dig Dis Sci
BACKGROUND: Cirrhosis is associated with poor health related quality of life (HRQOL), cognitive dysfunction (CD) and lack of coordination leading to falls. Tandem gait (TG;heel-toe) can be used to assess coordination. The impact and relationship betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb6247e8dae0a95f2d4fc4d3d05823c
https://doi.org/10.1007/s10620-020-06261-y
https://doi.org/10.1007/s10620-020-06261-y
Autor:
HoChong Gilles, Michael Fuchs, Scott C. Matherly, Omar Nadhem, Andrew Fagan, Leroy R. Thacker, Hannah Lee, Mohammad S. Siddiqui, Felicia Tinsley, Sara McGeorge, Ramzi Hassouneh, Arun J. Sanyal, Richard K. Sterling, Douglas M. Heuman, Jasmohan S Bajaj, Puneet Puri, Velimir A. Luketic, Chathur Acharya, James B. Wade, Jawaid Shaw
Publikováno v:
Am J Gastroenterol
Introduction We aimed to determine the effect of comorbidities on covert hepatic encephalopathy (CHE) diagnosis and overt hepatic encephalopathy (OHE) development. Methods Cirrhotic outpatients underwent CHE testing and 2-year follow-up. Cox regressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f7bff61afeebcb32bbdac2516888d0
https://europepmc.org/articles/PMC8683569/
https://europepmc.org/articles/PMC8683569/
Autor:
Jasmohan S. Bajaj, Masoumeh Sikaroodi, James B. Wade, HoChong Gilles, Michael Fuchs, Shahzor Nizam, Douglas M. Heuman, Javier González-Maeso, Patrick M. Gillevet, Edith A. Gavis, Andrew Fagan
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Posttraumatic stress disorder (PTSD) is associated with cirrhosis in veterans, and therapeutic results are suboptimal. An altered gut-liver-brain axis exists in cirrhosis due to hepatic encephalopathy (HE), but the added impact of PTSD is unclear. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962ca86da7693479c14f0d3e033c1532
https://doi.org/10.1152/ajpgi.00194.2019
https://doi.org/10.1152/ajpgi.00194.2019
Publikováno v:
Clinical Gastroenterology and Hepatology. 20:e1221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec189e43c42d09c5c41f84abefde9d70
https://doi.org/10.1016/j.cgh.2021.06.031
https://doi.org/10.1016/j.cgh.2021.06.031
Autor:
Venkata Rajesh Konjeti, Binu John, Eleanor Love, Latha Thankam Sundaram, Amit G. Singal, Cynthia Solomon, Yangyang Deng, James L. Tatum, Jennifer Hubert, Sean Aubuchon, Bassam Dahman, Smitha M. Thomas, Douglas M. Heuman
Publikováno v:
Liver Transpl
In this work, we characterize the value of positron emission tomography (PET) with computed tomography (CT) in combination with cross-sectional imaging for staging and prognostication of hepatocellular carcinoma (HCC) patients. In this retrospective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fe33f6e6ce4247c4434bd736cbfd01
https://europepmc.org/articles/PMC8006185/
https://europepmc.org/articles/PMC8006185/
Autor:
Phillip B. Hylemon, Shunlin Ren, William M. Pandak, Douglas M. Heuman, Lanming Chen, Yaping Wang
Publikováno v:
iScience, Vol 23, Iss 5, Pp-(2020)
iScience
iScience
Summary This work investigates the relationship between high-glucose (HG) culture, CpG methylation of genes involved in cell signaling pathways, and the regulation of carbohydrate and lipid metabolism in hepatocytes. The results indicate that HG lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add30f7d02071e5bd8101ea340d6468c
http://www.sciencedirect.com/science/article/pii/S258900422030287X
http://www.sciencedirect.com/science/article/pii/S258900422030287X
Autor:
Jagpal Singh Klair, Kavish R. Patidar, James B. Wade, Christopher Flud, Leroy R. Thacker, Edith Gavis, Douglas M. Heuman, Melanie B. White, Sanath Allampati, Andres Duarte-Rojo, Jasmohan S. Bajaj
Publikováno v:
Metabolic Brain Disease. 34:289-295
BACKGROUND & AIMS: Covert hepatic encephalopathy (CHE) affects cognition in a multidimensional fashion. Current guidelines recommend performing Psychometric Hepatic Encephalopathy Score (PHES) and a second test to diagnose CHE for multi-center trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132006e95ece3a62d97204ddded2c56d
https://doi.org/10.1007/s11011-018-0350-z
https://doi.org/10.1007/s11011-018-0350-z