Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Douglas Lazarus"'
Autor:
Robert S. Kerbel, Carolyn Krasner, Ping Xu, Christian G. Peters, Ursula A. Matulonis, Shan Man, Christina R. Lee, Douglas Lazarus, Edward G. Garmey, Scott Eliasof, Michael J. Birrer, Elizabeth Pham
Purpose: Increased tumor hypoxia and hence elevated hypoxia-inducible factor-1α (HIF1α) is thought to limit the efficacy of vascular endothelial growth factor (VEGF) pathway–targeting drugs by upregulating adaptive resistance genes. One strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2703f4aeca8077a90c697a527a910ca9
https://doi.org/10.1158/1078-0432.c.6523931.v1
https://doi.org/10.1158/1078-0432.c.6523931.v1
Autor:
Robert S. Kerbel, F. Stuart Foster, Scott Eliasof, Douglas Lazarus, Annabelle Chow, Ellen Rohde, Lata Jayaraman, Shan Man, Ping Xu, Donna Brown, Christina R. Lee, Christian G. Peters, Melissa Yin, Elizabeth Pham
VEGF pathway–targeting antiangiogenic drugs, such as bevacizumab, when combined with chemotherapy have changed clinical practice for the treatment of a broad spectrum of human cancers. However, adaptive resistance often develops, and one major mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8326e19cc9586d17287f85a14d80afba
https://doi.org/10.1158/0008-5472.c.6508295.v1
https://doi.org/10.1158/0008-5472.c.6508295.v1
Autor:
Robert S. Kerbel, F. Stuart Foster, Scott Eliasof, Douglas Lazarus, Annabelle Chow, Ellen Rohde, Lata Jayaraman, Shan Man, Ping Xu, Donna Brown, Christina R. Lee, Christian G. Peters, Melissa Yin, Elizabeth Pham
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c81d37323519ca66c2f3c1b5eb841b0
https://doi.org/10.1158/0008-5472.22411781
https://doi.org/10.1158/0008-5472.22411781
Autor:
Robert S. Kerbel, F. Stuart Foster, Scott Eliasof, Douglas Lazarus, Annabelle Chow, Ellen Rohde, Lata Jayaraman, Shan Man, Ping Xu, Donna Brown, Christina R. Lee, Christian G. Peters, Melissa Yin, Elizabeth Pham
Bioluminescence imaging of mice bearing primary LM2-4 tumors (S1); Assessment of MVD, HIF-1α, and tumoral drug accumulation in PDX primary tumors (S2); Immunohistochemistry staining for CD31, CAIX, caspase 3, Ki67, and HIF-1α, as well as in vitro V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173d464fc496bfd3274a5bef741dced1
https://doi.org/10.1158/0008-5472.22411784
https://doi.org/10.1158/0008-5472.22411784
Autor:
Robert S. Kerbel, Carolyn Krasner, Ping Xu, Christian G. Peters, Ursula A. Matulonis, Shan Man, Christina R. Lee, Douglas Lazarus, Edward G. Garmey, Scott Eliasof, Michael J. Birrer, Elizabeth Pham
Supplemental Figures 1-5 and Methods. This file describes the change in HIF-1α, HIF-2α and downstream markers (Fig. S1), anti-tumor efficacy and change in HIF-1α when combining CRLX101 with Aflibercept (Fig. S2) or Pazopanib (Fig. S3), dose-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317bc2735a439ca3b366162b704fd29
https://doi.org/10.1158/1078-0432.22458377
https://doi.org/10.1158/1078-0432.22458377
Autor:
Geeti Gangal, Sonke Svenson, Chester A. Metcalf, Pochi Shum, Snehlata Tripathi, Jungyeon Hwang, Stephanie Harlfinger, Beata Sweryda-Krawiec, Roy I. Case, Douglas Lazarus, Derek van der Poll, Sujan Kabir, Donna Brown, Ellen Rohde, Chi-Hse Teng, Roderic O. Cole, Scott Eliasof
Publikováno v:
Journal of Medicinal Chemistry. 62:9541-9559
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally vari
Autor:
Sunita Patel-Hett, Douglas Lazarus, Christian G. Peters, Amanda Leung, Sayaka Masuko, Dora E Kohnke, Lindsay Tomczak, Angelique Meredith, Brad Dykstra, Marcus Lehmann, Silvia Giannini, Dean Falb, Ryan Carpenter, Po-Shun Lee, Sophia Pete, Ashley J Russo
Publikováno v:
Blood. 138:1001-1001
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts ( Current treatment strategies for ITP include non-specific immunosuppression (steroids, rituximab), inhibition of platelet clearance (immunoglobulins, splen
Autor:
F. Stuart Foster, Donna Brown, Elizabeth Pham, Ellen Rohde, Lata Jayaraman, Christian G. Peters, Robert S. Kerbel, Annabelle Chow, Christina R. Lee, Shan Man, Melissa Yin, Ping Xu, Douglas Lazarus, Scott Eliasof
Publikováno v:
Cancer Research. 76:4493-4503
VEGF pathway–targeting antiangiogenic drugs, such as bevacizumab, when combined with chemotherapy have changed clinical practice for the treatment of a broad spectrum of human cancers. However, adaptive resistance often develops, and one major mech
Autor:
Pei-Sze Ng, Patrick Lim Soo, Sonke Svenson, Snehlata Tripathi, Roy I. Case, Sujan Kabir, Douglas Lazarus, Pochi Shum, Roderick O. Cole, Derek van der Poll, Jungyeon Hwang, Scott Eliasof, Beata Sweryda-Krawiec, Christian G. Peters
Publikováno v:
Molecular Pharmaceutics. 13:737-747
Small interfering RNA (siRNA) therapeutics have potential advantages over traditional small molecule drugs such as high specificity and the ability to inhibit otherwise "undruggable" targets. However, siRNAs have short plasma half-lives in vivo, can
Autor:
Christian G. Peters, Sarah J. Conley, Rebecca Theisen, Joseph Burnett, Trenton L. Baker, Douglas Lazarus, Shawn G. Clouthier, Max S. Wicha, Scott Eliasof
Publikováno v:
Breast Cancer Research and Treatment. 150:559-567
Antiangiogenic therapies inhibit the development of new tumor blood vessels, thereby blocking tumor growth. Despite the advances in developing antiangiogenic agents, clinical data indicate that these drugs have limited efficacy in breast cancer patie