Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Douglas Lamont"'
Autor:
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)
Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, inc
Externí odkaz:
https://doaj.org/article/6034f1d72e63418cb69e689338644a8d
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101661- (2023)
Objective: Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of metabolite and kinase-based immunometabolic control by AMP kinase. Methods:
Externí odkaz:
https://doaj.org/article/9997821d5e474d32b6b62c53f148b945
Autor:
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, ap
Externí odkaz:
https://doaj.org/article/ad825fe296684195b97f38283374885a
Autor:
Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M. Wishart, Thomas H. Gillingwater, Bernard L. Schneider, Mary-Ellen Harper, Simon H. Parson, Rashmi Kothary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take
Externí odkaz:
https://doaj.org/article/17bff1dec6fd49edbbb066b4aa9e5172
Autor:
Marcin Filipecki, Marek Żurczak, Mateusz Matuszkiewicz, Magdalena Święcicka, Wojciech Kurek, Jarosław Olszewski, Marek Daniel Koter, Douglas Lamont, Mirosław Sobczak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12147 (2021)
Cyst nematodes are important herbivorous pests in agriculture that obtain nutrients through specialized root structures termed syncytia. Syncytium initiation, development, and functioning are a research focus because syncytia are the primary interfac
Externí odkaz:
https://doaj.org/article/af4a019eee4b420b8d527bc13632c1ea
Autor:
Dan F Young, Elizabeth B Wignall-Fleming, David C Busse, Matthew J Pickin, Jack Hankinson, Elizabeth M Randall, Amy Tavendale, Andrew J Davison, Douglas Lamont, John S Tregoning, Steve Goodbourn, Richard E Randall
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007561 (2019)
Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses. Us
Externí odkaz:
https://doaj.org/article/a23a3a3339e44b22990637cb0bd641e7
Autor:
Aishe A Sarshad, Martin Corcoran, Bader Al-Muzzaini, Laura Borgonovo-Brandter, Anne Von Euler, Douglas Lamont, Neus Visa, Piergiorgio Percipalle
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004390 (2014)
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear. Here, we report that
Externí odkaz:
https://doaj.org/article/abd9b9408d794d7787070cbe9f534f6d
Autor:
Declan King, Kris Holt, Jamie Toombs, Xin HE, Owen Dando, Judith A Okely, Makis Tzioras, Jamie Rose, Ciaran Gunn, Adele Correia, Carmen Montero, Hannah McAlister, Jane Tulloch, Douglas Lamont, Adele M Taylor, Sarah E Harris, Paul Redmond, Simon R Cox, Christopher M Henstridge, Ian J Deary, Colin Smith, Tara L Spires‐Jones
Publikováno v:
King, D, Holt, K, Toombs, J, He, X, Dando, O, Okely, J, Rose, J, Gunn, C, Correia, A, Montero, C, Tulloch, J, Lamont, D, Taylor, A, Harris, S, Redmond, P, Cox, S R, Henstridge, C, Deary, I J, Smith, C & Spires-Jones, T 2022, ' Synaptic resilience is associated with maintained cognition during ageing ', Alzheimer's & Dementia: The Journal of the Alzheimer's Association . https://doi.org/10.1002/alz.12894
INTRODUCTION It remains unclear why age increases risk of Alzheimer’s disease and why some people experience age-related cognitive decline in the absence of dementia. Here we test the hypothesis that resilience to molecular changes in synapses cont
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular metabolism.
Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we combine whole cell quantitative proteomics with gene knockout of AMPKα1, to demonstrate integration of metabolite
Publikováno v:
Molecular and cellular biochemistry. 456(1-2)
Stroke is a common disorder with significant morbidity and mortality, and complex aetiology involving both environmental and genetic risk factors. Although some of the major risk factors for stoke, such as smoking and hypertension, are well-documente