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pro vyhledávání: '"Douglas L. Falls"'
Autor:
Kristen Frenzel, Douglas L. Falls
Publikováno v:
Journal of Neurochemistry. 77:1-12
Publikováno v:
European Journal of Neuroscience. 26:593-604
Mitotically active progenitor cells from the anterior portion of the forebrain subventricular zone (SVZa), which give rise throughout life to olfactory bulb interneurons, bear processes and express neuronal markers. To understand how rodent SVZa neur
Publikováno v:
The Journal of Neuroscience. 27:5837-5844
Visualizing the proliferation marker bromodeoxyuridine (BrdU) requires pretreatment of tissue, typically with dilute hydrochloric acid (HCl). We report here that pretreatment by steam heating of paraformaldehyde-fixed tissue sections covered with cit
Autor:
Douglas L. Falls
Publikováno v:
Journal of Neurocytology. 32:619-647
The neuregulins were originally discovered in searches for the acetylcholine receptor-inducing activity (ARIA), glial growth factor (GGF), and a ligand for the oncogene neu (ErbB2/HER2). Neuregulin1 (NRG1)-mediated cell communication is critical in t
Autor:
Michael F. Jackson, Yu Zhang, Vitali Tregoubov, Douglas L. Falls, Jay Y. Wang, Zhengping Jia, Wei-Yang Lu, Yanghong Meng, Christopher Janus, John F. MacDonald, Luis Cruz
Publikováno v:
Neuron. 35(1):121-133
In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in v
Autor:
Kristen Frenzel, Douglas L. Falls
Publikováno v:
Journal of Neurochemistry. 77:1-12
Neuregulin-1 proteins and their receptors, which are members of the ErbB subfamily of receptor tyrosine kinases, play essential roles in the development of the nervous system and heart. Most neuregulin-1 isoforms are synthesized as transmembrane prop
Publikováno v:
The Journal of Comparative Neurology. 416:319-334
LIM kinase 1 (LIMK1) is a cytoplasmic protein kinase that is highly expressed in neurons. In transfected cells, LIMK1 binds to the cytoplasmic tail of neuregulins and regulates the breakdown of actin filaments. To identify potential functions of LIMK
Publikováno v:
Journal of Biological Chemistry. 273:20525-20534
The neuregulins are receptor tyrosine kinase ligands that play a critical role in the development of the heart, nervous system, and breast. Unlike many extracellular signaling molecules, such as the neurotrophins, most neuregulins are synthesized as
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 55:397-406
Autor:
Arrel D. Toews, Steven Einheber, Ashley Petrylak, Pratik Thaker, Carla Taveggia, Gregg L. Caporaso, Douglas L. Falls, James L. Salzer
Publikováno v:
Glia. 56(3)
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of ne