Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Douglas L. Black"'
Autor:
Jennifer M. Achiro, Yang Tao, Fuying Gao, Chia-Ho Lin, Marika Watanabe, Sylvia Neumann, Giovanni Coppola, Douglas L. Black, Kelsey C. Martin
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Aging-related memory impairment and pathological memory disorders such as Alzheimer’s disease differ between males and females, and yet little is known about how aging-related changes in the transcriptome and chromatin environment differ between se
Externí odkaz:
https://doaj.org/article/40dfcd13efbb453ea7a5c84a591776c2
Autor:
Kevin Qian, Marcus J. Tol, Jin Wu, Lauren F. Uchiyama, Xu Xiao, Liujuan Cui, Alexander H. Bedard, Thomas A. Weston, Pradeep S. Rajendran, Laurent Vergnes, Yuta Shimanaka, Yesheng Yin, Yasaman Jami-Alahmadi, Whitaker Cohn, Bryce T. Bajar, Chia-Ho Lin, Benita Jin, Laura A. DeNardo, Douglas L. Black, Julian P. Whitelegge, James A. Wohlschlegel, Karen Reue, Kalyanam Shivkumar, Feng-Jung Chen, Stephen G. Young, Peng Li, Peter Tontonoz
Publikováno v:
Nature
Multilocular adipocytes are a hallmark of thermogenic adipose tissue(1,2), but the factors that enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte-selective product of the Clstn3 locus (CLSTN3β) present in only plac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d398f0ffd1d3e335b793aade13ff43e3
https://doi.org/10.1038/s41586-022-05507-1
https://doi.org/10.1038/s41586-022-05507-1
Fluorescence In Situ Hybridization (FISH) is a widely used tool for quantifying gene expression and determining the location of RNA molecules in cells. Here, we present an improved method for FISH probe production that yields high purity probes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c187b6d958cc08e8b796928848b49bd3
https://doi.org/10.1101/2023.01.10.523484
https://doi.org/10.1101/2023.01.10.523484
Autor:
Xinyuan Chen, Harry Taegyun Yang, Beatrice Zhang, John W. Phillips, Donghui Cheng, Frank Rigo, Owen N. Witte, Yi Xing, Douglas L. Black
The Myc proto-oncogene contributes to the pathogenesis of more than half of human cancers. Malignant transformation by Myc transcriptionally upregulates the core pre-mRNA splicing machinery and causes mis-regulation of alternative splicing. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1148572a21ff7b745cfe5cf5bcaaf36b
https://doi.org/10.1101/2022.11.29.518269
https://doi.org/10.1101/2022.11.29.518269
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/cb41252e8aff4313b26190835a1b31e5
Autor:
Somsakul Pop Wongpalee, Ajay Vashisht, Shalini Sharma, Darryl Chui, James A Wohlschlegel, Douglas L Black
Publikováno v:
eLife, Vol 5 (2016)
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found tha
Externí odkaz:
https://doaj.org/article/8fe5bb0589a94dafa6af63e39eba462d
Autor:
Chun-Kan Chen, Douglas L. Black, Anthony Chau, Yolanda Markaki, Andrey Damianov, Sika Zheng, Shan Sabri, Mitchell Guttman, Bernadett Papp, Constantinos Chronis, Amy Pandya-Jones, Jacques Serizay, Xiao-Jun Wang, Walter R. Mancia Leon, Tsotne Chitiashvili, Robin McKee, Heinrich Leonhardt, Kathrin Plath
Publikováno v:
Nature
Nature, vol 587, iss 7832
Nature, vol 587, iss 7832
Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear1. The long non-coding RNA Xist establishes an intra-chromosomal compartment by loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061516d16df1f9e5d58501bf4971a0ad
http://europepmc.org/articles/PMC7644664
http://europepmc.org/articles/PMC7644664