Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Douglas L, Sheridan"'
Publikováno v:
Blood. 138:3153-3153
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal alloantibodies directed against paternally inherited antigens present on the surface of fetal and neonatal platelets. The human platelet all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57aedc2ceebb80207efa6befef56f911
https://doi.org/10.1182/blood-2021-148557
https://doi.org/10.1182/blood-2021-148557
Autor:
Gregers R. Andersen, Janus Asbjørn Schatz-Jakobsen, Yuchun Zhang, Douglas L. Sheridan, Alyssa Neill, Krista Johnson
Publikováno v:
Schatz-Jakobsen, J A, zhang, Y, Johnson, K, Neill, A, Sheridan, D & Andersen, G R 2016, ' Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway ', Journal of Immunology, vol. 197, no. 1, pp. 337-344 . https://doi.org/10.4049/jimmunol.1600280
Eculizumab is a humanized mAb approved for treatment of patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Eculizumab binds complement component C5 and prevents its cleavage by C5 convertases, inhibiting release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a59362d7e96737b4646781566a671a
https://doi.org/10.4049/jimmunol.1600280
https://doi.org/10.4049/jimmunol.1600280
Autor:
Melissa A. Lasaro, Yuchun Zhang, Fang Sun, Paul P. Tamburini, Zhao-Xue Yu, Rekha Patel, Yi Wang, Keith Bouchard, Bruce A. Andrien, Douglas L. Sheridan, Andre Marozsan
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195909 (2018)
PLoS ONE
PLoS ONE
Eculizumab, a monoclonal antibody (mAb) directed against complement protein C5, is considered to be the current standard of care for patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. This study describes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa3c304652ecd9e742feb0f2d94afa1
https://doi.org/10.1371/journal.pone.0195909
https://doi.org/10.1371/journal.pone.0195909
Autor:
Rekha Patel, Yi Wang, Douglas L. Sheridan, Andre Marozsan, Keith Bouchard, Melissa A. Lasaro, Zhao-Xue Yu, Bruce A. Andrien, Paul P. Tamburini, Yuchun Zhang
Publikováno v:
Immunobiology. 221:1158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223e6da3e1ccad919ed88297143181a5
https://doi.org/10.1016/j.imbio.2016.06.078
https://doi.org/10.1016/j.imbio.2016.06.078
Autor:
Grace R. Jeschke, Matthew C. Good, Xiuqiong Zhou, Nancy M. Hollingsworth, Bruce Stillman, Wendell A. Lim, David F. Stern, Philip M. Kim, Richelle Sopko, Miri Jwa, Brenda J. Andrews, Mark Gerstein, Janine Mok, Stacy Piccirillo, Attila Remenyi, Ved Desai, Michael Snyder, Hugo Y. K. Lam, Sirlester A. Parker, Hengyao Niu, Holly E. Sassi, Clarence S.M. Chan, Benjamin E. Turk, Elisabetta Cameroni, Yi-Jun Sheu, Jia Lin Nianhan Ma, Claudio De Virgilio, Douglas L. Sheridan
Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8687e86b66c571a7fd1182e9885281
http://doc.rero.ch/record/17524/files/vir_dpk_sm.pdf
http://doc.rero.ch/record/17524/files/vir_dpk_sm.pdf
Publikováno v:
The Journal of biological chemistry. 283(28)
Mitogen-activated protein kinases (MAPKs) mediate cellular responses to a wide variety of extracellular stimuli. MAPK signal transduction cascades are tightly regulated, and individual MAPKs display exquisite specificity in recognition of their targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff87d2cc13b75d8719b5ce423018c9f
https://pubmed.ncbi.nlm.nih.gov/18482985
https://pubmed.ncbi.nlm.nih.gov/18482985
Autor:
Keith Bouchard, Leonardo Sahelijo, Paresh Soni, Bruce A. Andrien, David Mitchell, Richard Larouche, Rekha Patel, Susan Macdonald, Paul P. Tamburini, Yi Wang, Douglas L. Sheridan, Yuchun Zhang, Melissa A. Lasaro, Arshad Mujeebuddin, Zhao-Xue Yu
Publikováno v:
Blood. 126:4777-4777
Introduction: ALXN1210 is a humanized monoclonal antibody (mAb), with a sequence closely related to eculizumab (Soliris®). ALXN1210 binds specifically to human complement protein C5 and was engineered to eliminate the formation of C5a and the termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7e7e7feb1f108151c759ff9bb250fe
https://doi.org/10.1182/blood.v126.23.4777.4777
https://doi.org/10.1182/blood.v126.23.4777.4777
Publikováno v:
Neuroscience. 141(2)
The green fluorescent protein can be fused to the ends of a mature glutamate receptor subunit to produce functional, fluorescent receptors. However, there are good reasons to search for internal regions of receptor subunits that can tolerate green fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f585d757e75eb9a4904c019961309a
https://pubmed.ncbi.nlm.nih.gov/16765522
https://pubmed.ncbi.nlm.nih.gov/16765522
Autor:
Sonjoo Son, Daniela Gorbecheva, John Tierney, Michelle Ripp, Linda M. Mascavage, Douglas L. Sheridan
Publikováno v:
Heterocyclic Communications. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2f232554a4bd166f06736c393c4e31
https://doi.org/10.1515/hc.2005.11.3-4.215
https://doi.org/10.1515/hc.2005.11.3-4.215
Publikováno v:
Molecular pharmacology. 66(3)
The neurotoxin 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP) damages forebrain serotonin (5-HT) and norepinephrine (NE) nerve terminals while sparing striatal dopaminergic innervation. Previous studies suggest that 2'-NH(2)-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ade3067ab5419729360b4261cc89c34d
https://pubmed.ncbi.nlm.nih.gov/15322265
https://pubmed.ncbi.nlm.nih.gov/15322265