Teduglutide for the treatment of adults with intestinal failure associated with short bowel syndrome: pooled safety data from four clinical trials

Autor: Ulrich-Frank Pape, Kishore R. Iyer, Palle B. Jeppesen, Marek Kunecki, Loris Pironi, Stéphane M. Schneider, Douglas L. Seidner, Hak-Myung Lee, John Caminis

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 13 (2020)

Background: In multiple clinical studies, teduglutide reduced parenteral support (PS) with a consistent safety profile in adults with short bowel syndrome–associated intestinal failure (SBS–IF). The objective of this study was to assess adverse e

Externí odkaz: https://doaj.org/article/fefa5e6e8c5f48fb957275a629cceef6

Characteristics of chronic intestinal failure in the USA based on analysis of claims data

Autor: Manpreet S. Mundi, David F. Mercer, Kishore Iyer, Daniel Pfeffer, Lis B. Zimmermann, Mark Berner‐Hansen, Joan Bishop, Douglas L. Seidner

Publikováno v: Journal of Parenteral and Enteral Nutrition. 46:1614-1622

This study investigated the prevalence, characteristics, and management of patients with chronic intestinal failure (CIF) in the United States in 2012-2020, based on parenteral support (PS) prescription claims and healthcare utilization.Patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511cf4fddcdccd82e1cd7a1def40832f
https://doi.org/10.1002/jpen.2426

Citrulline correlations in short bowel syndrome–intestinal failure by patient stratification: Analysis of 24 weeks of teduglutide treatment from a randomized controlled study

Autor: Simon M. Gabe, Palle Jeppesen, Clément Olivier, Douglas L. Seidner, Hak-Myung Lee

Publikováno v: Jeppesen, P B, Gabe, S M, Seidner, D L, Lee, H-M & Olivier, C 2020, ' Citrulline correlations in short bowel syndrome-intestinal failure by patient stratification : Analysis of 24 weeks of teduglutide treatment from a randomized controlled study ', Clinical Nutrition, vol. 39, no. 8, pp. 2479-2486 . https://doi.org/10.1016/j.clnu.2019.11.001

BACKGROUND & AIMS: Disease-associated factors influence parenteral support (PS) reduction in response to teduglutide in patients with intestinal failure associated-short bowel syndrome (SBS-IF). We sought to determine correlative relationships betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aa57d5a22890dd3f6ba0fff65fb4aa
https://doi.org/10.1016/j.clnu.2019.11.001

Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials

Autor: Clément Olivier, Hak-Myung Lee, Simon M. Gabe, Palle Jeppesen, Douglas L. Seidner

Publikováno v: JPEN. Journal of Parenteral and Enteral Nutrition
Seidner, D L, Gabe, S M, Lee, H-M, Olivier, C & Jeppesen, P B 2020, ' Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials ', Journal of Parenteral and Enteral Nutrition, vol. 44, no. 4, pp. 697-702 . https://doi.org/10.1002/jpen.1687

BACKGROUND: Teduglutide response, in terms of parenteral support (PS) volume reduction, is associated with specific disease characteristics among adults with short bowel syndrome-associated intestinal failure (SBS-IF). Whether these associations appl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bb05b3dfb62ba41f740a28cc8613c5
https://doi.org/10.1002/jpen.1687

On the robustness of inference of association with the gut microbiota in stool, swab and mucosal tissue samples

Autor: Xiang Huang, Reid M. Ness, Anthony A. Fodor, Qi Dai, Martha J. Shrubsole, Xiangzhu Zhu, M. Andrea Azcarate-Peril, Ivory C. Blakley, Chang Yu, Harvey J. Murff, Shan Sun, Alicia Sorgen, Douglas L. Seidner

The gut microbiota plays an important role in human health and disease. Stool, swab and mucosal tissue samples have been used in individual studies to survey the microbial community but the consequences of using these different sample types are not c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22de747b4a2d0058318397886bceacea
https://doi.org/10.1101/2021.02.04.429844