Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Douglas L, Rothman"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Since Jacob and Monod’s discovery of the lac operon ∼1960, the explanations offered for most metabolic adaptations have been genetic. The focus has been on the adaptive changes in gene expression that occur, which are often referred to as “meta
Externí odkaz:
https://doaj.org/article/2b82dc442e1147c081798bdcadc8bac9
Autor:
Douglas L Rothman, Robert G. Shulman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 879-886 (2021)
Previously we suggested that the early Warburg effect can be explained by the use by cancer cells the glycogen shunt during a rapid increase in glucose concentration. In analogy to the Crabtree effect in yeast, the shunt plays a critical role in main
Externí odkaz:
https://doaj.org/article/fb7bf77a936649e9a15e35cbece717f4
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Background Nonalcoholic fatty liver affects 25% to 30% of the US and European populations; is associated with insulin resistance (IR), type 2 diabetes, and increased cardiovascular risk; and is defined by hepatic triglyceride (HTG) content greater th
Externí odkaz:
https://doaj.org/article/70bbdce028414b128c4cf3dc7bdf4df3
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
What defines the rate of energy use by the brain, as well as per neurons of different sizes in different structures and animals, is one fundamental aspect of neuroscience for which much has been theorized, but very little data are available. The prev
Externí odkaz:
https://doaj.org/article/5f2ca3ecb75b430db85565893b487446
Autor:
Lynnette A. Averill, Lihong Jiang, Prerana Purohit, Anastasia Coppoli, Christopher L. Averill, Jeremy Roscoe, Benjamin Kelmendi, Henk M. De Feyter, Robin A de Graaf, Ralitza Gueorguieva, Gerard Sanacora, John H. Krystal, Douglas L. Rothman, Graeme F. Mason, Chadi G. Abdallah
Publikováno v:
Chronic Stress, Vol 6 (2022)
Background Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel p
Externí odkaz:
https://doaj.org/article/9a7f7965ac9f4df9a4deec5793fd8086
Autor:
Sarah Caldwell, Douglas L. Rothman
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
At present, limited biomarkers exist to reliably understand, diagnose, and monitor the progression of amyotrophic lateral sclerosis (ALS), a fatal neurological disease characterized by motor neuron death. Standard MRI technology can only be used to e
Externí odkaz:
https://doaj.org/article/223a8edb0310473abd01df9c0e31c242
Autor:
Jessica E Rothman, David Eidelberg, Samantha L Rothman, Theodore R Holford, Douglas L Rothman
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0253843 (2021)
BackgroundKnowing the true infected and symptomatic case fatality ratios (IFR and CFR) for COVID-19 is of high importance for epidemiological model projections. Early in the pandemic many locations had limited testing and reporting, so that standard
Externí odkaz:
https://doaj.org/article/e7c3fa5b238d48a8ac8f37299d382456
Autor:
Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic flux
Externí odkaz:
https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b
Autor:
Graeme F. Mason, Gerard Sanacora, Ying Chen, Douglas L. Rothman, Liza Gantert, Kenneth D. Anderson, Stephen F. Previs, Corin O. Miller, Justina M. Thomas, Jason M. Uslaner
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:598-606
Background The development of treatments for cognitive deficits associated with central nervous system disorders is currently a significant medical need. Despite the great need for such therapeutics, a significant challenge in the drug development pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35e6664236c9b7a418102a2157076e5
https://doi.org/10.1016/j.bpsc.2020.09.014
https://doi.org/10.1016/j.bpsc.2020.09.014
Autor:
Robert G. Shulman, Douglas L. Rothman
Publikováno v:
Frontiers in Human Neuroscience, Vol 13 (2019)
The dominant model for interpreting brain imaging experiments, which we refer to as the Standard Cognitive Model (SCM), assumes that the brain is organized in support of mental processes that control behavior. However, functional neuroimaging experim
Externí odkaz:
https://doaj.org/article/b76e34a117e44bb3924b3b417614c01f