Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Douglas Koshland"'
Autor:
Siheng Xiang, Douglas Koshland
Publikováno v:
eLife, Vol 10 (2021)
Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains
Externí odkaz:
https://doaj.org/article/22f016cec1bc44519ab67099b79f9a43
Publikováno v:
eLife, Vol 9 (2020)
The organization of chromatin into higher order structures is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene expression. Using Micro-C XL to detect chromosomal interactions, we observed the pervasive presen
Externí odkaz:
https://doaj.org/article/7391034be73a4c518c8db9258b48a4ba
Publikováno v:
eLife, Vol 7 (2018)
Anhydrobiotes are rare microbes, plants and animals that tolerate severe water loss. Understanding the molecular basis for their desiccation tolerance may provide novel insights into stress biology and critical tools for engineering drought-tolerant
Externí odkaz:
https://doaj.org/article/a9746c5fba25405ca66f791a7061e66b
Autor:
Jeremy D Amon, Douglas Koshland
Publikováno v:
eLife, Vol 5 (2016)
R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-l
Externí odkaz:
https://doaj.org/article/fc5817e4c7b541328e7bfd9e365ffc06
Publikováno v:
eLife, Vol 4 (2015)
Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPa
Externí odkaz:
https://doaj.org/article/59bbd422b8d44826b0be02a3db32a3d9
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005036 (2015)
The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and
Externí odkaz:
https://doaj.org/article/a63c9771bf9b43a48bfaae1dea76198b
Publikováno v:
eLife, Vol 2 (2013)
Genome instability in yeast and mammals is caused by RNA–DNA hybrids that form as a result of defects in different aspects of RNA biogenesis. We report that in yeast mutants defective for transcription repression and RNA degradation, hybrid formati
Externí odkaz:
https://doaj.org/article/b956af19fe9149e59970ee9dc9b0e186
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002633 (2012)
DNA double-strand breaks impact genome stability by triggering many of the large-scale genome rearrangements associated with evolution and cancer. One of the first steps in repairing this damage is 5'→3' resection beginning at the break site. Recen
Externí odkaz:
https://doaj.org/article/b494a8242295403e9165f800cc378978
Autor:
Margaret L Hoang, Frederick J Tan, David C Lai, Sue E Celniker, Roger A Hoskins, Maitreya J Dunham, Yixian Zheng, Douglas Koshland
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001228 (2010)
Genome rearrangements often result from non-allelic homologous recombination (NAHR) between repetitive DNA elements dispersed throughout the genome. Here we systematically analyze NAHR between Ty retrotransposons using a genome-wide approach that exp
Externí odkaz:
https://doaj.org/article/44485b86523a44119d8fcbbac618ea2d
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2453 (2008)
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subu
Externí odkaz:
https://doaj.org/article/b994fadd386d4bb7b1ee5fa2aa9201a1