Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Douglas K. Fischer"'
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
The V179I substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected in humans or mouse models treated with certain nonnucleoside reverse transcriptase inhibitors (NNRTIs). While it is often observed together w
Externí odkaz:
https://doaj.org/article/e6bf06357e9344a6a8990bd0201f3359
Publikováno v:
Viruses, Vol 13, Iss 11, p 2237 (2021)
The human immunodeficiency virus type 1 (HIV-1) capsid and its disassembly, or capsid uncoating, has remained an active area of study over the past several decades. Our understanding of the HIV-1 capsid as solely a protective shell has since shifted
Externí odkaz:
https://doaj.org/article/6ed1da04856a4e8b8ec6a348399e943a
Autor:
Hu Zhang, Douglas K. Fischer, Masahiro Shuda, Patrick S. Moore, Shou‐Jiang Gao, Zandrea Ambrose, Haitao Guo
Publikováno v:
Journal of medical virology. 94(6)
The ongoing COVID-19 pandemic severely impacts global public health and economies. To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virology and antiviral discovery, a noninfectious viral replicon system operatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4068a4c86e44c86395a55ae766c65ba
https://pubmed.ncbi.nlm.nih.gov/35137972
https://pubmed.ncbi.nlm.nih.gov/35137972
Publikováno v:
Viruses, Vol 13, Iss 2237, p 2237 (2021)
Viruses
Viruses
The human immunodeficiency virus type 1 (HIV-1) capsid and its disassembly, or capsid uncoating, has remained an active area of study over the past several decades. Our understanding of the HIV-1 capsid as solely a protective shell has since shifted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ca980e10cfb8f596815bb08341521c
https://www.mdpi.com/1999-4915/13/11/2237
https://www.mdpi.com/1999-4915/13/11/2237
Autor:
Damien Ferhadian, Upul D. Halambage, Douglas K. Fischer, Mohammad Adnan Siddiqui, Christopher Aiken, Ashwanth C. Francis, Akatsuki Saito, Gregory B. Melikyan, Zandrea Ambrose, Masahiro Yamashita
The HIV-1 capsid executes essential functions that are regulated by capsid stability and host factors. In contrast to increasing knowledge on functional roles of capsid-interacting host proteins during postentry steps, less is known about capsid stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e60325b66df58b50b4d2be357a07f
https://europepmc.org/articles/PMC6675898/
https://europepmc.org/articles/PMC6675898/
Autor:
Douglas K. Fischer, Zandrea Ambrose, Masahiro Yamashita, Simon C. Watkins, Christopher E. Kline, Romy Cohen, Akatsuki Saito
Publikováno v:
Journal of Virology. 93
The ability of human immunodeficiency virus type 1 (HIV-1) to transduce nondividing cells is key to infecting terminally differentiated macrophages, which can serve as a long-term reservoir of HIV-1 infection. The mutation N57A in the viral CA protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6476e130fa2821507da88e8afa1d9c
https://doi.org/10.1128/jvi.00214-19
https://doi.org/10.1128/jvi.00214-19
Autor:
Paul L. Boyer, Linda L. Dunn, Steven J. Smith, Richa Dwivedi, Douglas K. Fischer, Pat Clark, Stephen H. Hughes, Chris Kline, Kevin Melody, Zandrea Ambrose
Publikováno v:
Journal of Virology
Although antiretroviral therapy (ART) is highly successful, drug-resistant variants can arise that blunt the efficacy of ART. New inhibitors that are broadly effective against known drug-resistant variants are needed, although such compounds might se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb70e9170f223406aa0f293dbe410c87
http://europepmc.org/articles/PMC6532099
http://europepmc.org/articles/PMC6532099
Autor:
Douglas K. Fischer, Peijun Zhang, Zandrea Ambrose, Zhou Zhong, Gemma Harris, Simon C. Watkins, Jiying Ning
Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration complexes. Truncation of the protein at its C-terminal nuclear-targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b731dd06058b3c29f68b57ab9491d0d3
https://ora.ox.ac.uk/objects/uuid:1237581d-604c-43a1-a389-87b7bc34262b
https://ora.ox.ac.uk/objects/uuid:1237581d-604c-43a1-a389-87b7bc34262b
Autor:
Saumendra N. Sarkar, Katherine M. Eichinger, Jennifer M. Bomberger, Matthew R. Hendricks, Douglas K. Fischer, Joan E. Durbin, Carolyn B. Coyne, Lauren P. Lashua, Kerry M. Empey, Becca A. Flitter
Clinical observations link respiratory virus infection and Pseudomonas aeruginosa colonization in chronic lung disease, including cystic fibrosis (CF) and chronic obstructive pulmonary disease. The development of P. aeruginosa into highly antibiotic-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3785b732df8b5c6c4296345c448879fe
https://europepmc.org/articles/PMC4760822/
https://europepmc.org/articles/PMC4760822/
Publikováno v:
The FASEB Journal. 28
Clinical observations link respiratory virus infection and Pseudomonas aeruginosa colonization in chronic lung disease, including cystic fibrosis and chronic obstructive pulmonary disease. The development of P. aeruginosa into highly antibiotic resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14fa7629810a6b51636b0e5329bf89ac
https://doi.org/10.1096/fasebj.28.1_supplement.869.1
https://doi.org/10.1096/fasebj.28.1_supplement.869.1