Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Douglas K, Graham"'
Autor:
Hope L. Mumme, Sunil S. Raikar, Swati S. Bhasin, Beena E. Thomas, Taylor Lawrence, Elizabeth P. Weinzierl, Yakun Pang, Deborah DeRyckere, Chuck Gawad, Daniel S. Wechsler, Christopher C. Porter, Sharon M. Castellino, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Background Mixed phenotype acute leukemia (MPAL), a rare subgroup of leukemia characterized by blast cells with myeloid and lymphoid lineage features, is difficult to diagnose and treat. A better characterization of MPAL is essential to unde
Externí odkaz:
https://doaj.org/article/27b0d44d90b644919eac2539e49cde72
Autor:
Hope Mumme, Beena E. Thomas, Swati S. Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Pruthvi Perumalla, Debasree Sarkar, Gulay B. Ulukaya, Himalee S. Sabnis, Sunita I. Park, Deborah DeRyckere, Sunil S. Raikar, Melinda Pauly, Ryan J. Summers, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx),
Externí odkaz:
https://doaj.org/article/a3787863b5cb43ff9dcb50ae8a436b4d
Autor:
Swati S. Bhasin, Beena E. Thomas, Ryan J. Summers, Debasree Sarkar, Hope Mumme, William Pilcher, Mohamed Emam, Sunil S. Raikar, Sunita I. Park, Sharon M. Castellino, Douglas K. Graham, Manoj K. Bhasin, Deborah DeRyckere
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Different driver mutations and/or chromosomal aberrations and dysregulated signaling interactions between leukemia cells and the immune microenvironment have been implicated in the development of T-cell acute lymphoblastic leukemia (T-ALL).
Externí odkaz:
https://doaj.org/article/bad7ef4e0fc14a73bb94f1c5d3d5576c
Autor:
Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, William T Tse, Svetlana Dambaeva, Sylvia Schneiderman, Philip M Iannaccone, Oren Becher, Douglas K Graham, Vasiliy Galat
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTBackground Immunotherapeutic innovation is crucial for limited operability tumors. CAR T-cell therapy displayed reduced efficiency against glioblastoma (GBM), likely due to mutations underlying disease progression. Natural Killer cells (NKs)
Externí odkaz:
https://doaj.org/article/f5129c7ae29c4141b8f9be0db6d6b0b2
Autor:
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL
Externí odkaz:
https://doaj.org/article/2dbae7c4d3ee43d79487bfe5ab1bc1e6
Autor:
Joselyn Cruz Cruz, Kristen C. Allison, Lauren S. Page, Alexis J. Jenkins, Xiaodong Wang, H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Michael R. Verneris, Alisa B. Lee-Sherick
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process
Externí odkaz:
https://doaj.org/article/6c936b3c3cbd434da91afc7829838a3a
Autor:
Dan Yan, Justus M. Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Subir Goyal, Xiaodong Wang, Stephen V. Frye, Madhusmita Behera, Frank Schneider, Suresh S. Ramalingam, Taofeek Owonikoko, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Acquired resistance is inevitable in non–small cell lung cancers (NSCLCs) treated with osimertinib (OSI), and the mechanisms are not well defined. The MERTK ligand GAS6 promoted downstream oncogenic signaling in EGFR-mutated (EGFRMT) NSCLC cells tr
Externí odkaz:
https://doaj.org/article/dc8fcbaf4b6443d0b3ac710d3a2feecb
Autor:
Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page, Amanda A. Hill, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Craig T. Jordan, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Externí odkaz:
https://doaj.org/article/1697272d99124244a315c31b3901c007
Autor:
H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Xiaodong Wang, Qingyang Liu, Dehui Zhang, Yuewei Zhang, Jichen Zhao, Debra M. Hunter, Eric Ubil, William Harris, Alisha Holtzhausen
Supplementary Figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f3ef7f6c3accd5340b3bf4b5b3217a
https://doi.org/10.1158/2326-6066.22542306
https://doi.org/10.1158/2326-6066.22542306
Autor:
H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Xiaodong Wang, Qingyang Liu, Dehui Zhang, Yuewei Zhang, Jichen Zhao, Debra M. Hunter, Eric Ubil, William Harris, Alisha Holtzhausen
legends for sup figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de457e9fe37e53e01683414037c6b4
https://doi.org/10.1158/2326-6066.22542309.v1
https://doi.org/10.1158/2326-6066.22542309.v1