Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Douglas James Riexinger"'
Autor:
Claudio Mapelli, Douglas James Riexinger, Kimberly Voronin, Jianing Zeng, Ving G. Lee, Samuel J. Bonacorsi, Sharon Gong, Nishith Sanghvi, Hao Jiang, Alban Allentoff
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:579-583
The synthesis of a 16-residue, stable isotopically labeled peptide is described for use as a LC-MS/MS (Liquid chromatography-mass spectrometry/mass spectrometry) internal standard in bioanalytical studies. This peptide serves as a single universal su
Autor:
Li Xin, Ming Lei, Claudio Mapelli, Tasir Shamsul Haque, Ge Zhang, John Krupinski, Sarah E. Malmstrom, Ving G. Lee, Douglas James Riexinger, Songping Han, William R. Ewing, Cooper Christopher B
Publikováno v:
Peptides. 31:950-955
We report the identification of potent agonists of the Glucagon-Like Peptide-1 Receptor (GLP-1R). These compounds are short, 11 amino acid peptides containing several unnatural amino acids, including (in particular) analogs of homohomophenylalanine (
Autor:
Claudio Mapelli, Ramakrishna Seethala, Songping Han, Ellen Sieber-McMaster, William R. Ewing, Ashish Khanna, Keith L. Constantine, Douglas James Riexinger, Daniel Longhi, John Krupinski, Zhengping Ma, Constance Smith-Monroy, Bastos Margarita M, Dan Shi, Michael S. Bernatowicz, Joseph R. Taylor, Christine Huang, Rajasree Golla, Gordon William Robinson, Jelka Pluscec, Jean M. Whaley, Sesha Natarajan, Jean-Philippe Meyer, Robert H. Stoffel, Li Xin, Ving G. Lee, Barry Koplowitz, Cecilia L Chi, Ildiko Antal-Zimanyi
Publikováno v:
Journal of Medicinal Chemistry. 52:7788-7799
Glucagon-like peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological regulation of glucose homeostasis and food intake. Herein, we report the discovery of a novel class of 11 amino acid GLP-1 receptor agonist
Publikováno v:
International Journal of Peptide and Protein Research. 45:145-151
Proteolytic action of alpha-thrombin on human thrombin receptor results in cleavage of a portion of the N-terminus, thereby generating a 'tethered ligand' at the newly exposed N-terminus, which then activates the receptor in an intramolecular fashion
Autor:
Steven M. Seiler, Sesha Natarajan, Douglas James Riexinger, Marianne Peluso, Harold Goldenberg, Inge M. Michel, John W. Fenton
Publikováno v:
Biochemical Pharmacology. 49:519-528
A thrombin receptor has been described that is activated by thrombin cleavage generating a new N-terminus. The newly exposed SFLLR-containing “tethered-ligand” then activates the receptor. In these studies, we used 3-mercapto-propionyl-Phe-Cha-Ch
Autor:
Stephen M. Festin, Sesha Natarajan, Claudio Mapelli, S P Weinheimer, C.L. DiIanni, Jonglin Tsao, Douglas James Riexinger, Gregory Yamanaka, D A Drier, Mark S. Bolgar
Publikováno v:
Journal of Biological Chemistry. 268:25449-25454
Herpes simplex virus type-1 (HSV-1) protease is responsible for proteolytic processing of itself and the virus assembly protein ICP35 (infected cell protein 35). Two proteolytic processing sites within the protease have recently been identified betwe
Autor:
Claudio Mapelli, Patricia A. McDonnell, James R. Burke, Joann Strnad, Hilary Gray, Rolf Ryseck, Lihong Cheng, Douglas James Riexinger
Publikováno v:
Journal of molecular recognition : JMR. 19(3)
NF-κB activation is mediated by the IKK signalsome. Though this signalsome is comprised of IKK-1, IKK-2, and NEMO/IKKγ, it is the interaction between IKK-2 and NEMO that is critical to formation of a functional signalsome. More specifically, previo
Autor:
Michael G. Kornacker, William J. Metzler, Jianghong Ma, Claudio Mapelli, Zhihong Lai, Ving G. Lee, Douglas James Riexinger, Joseph P. Hendrick, Robert A. Copeland, Mark R. Witmer
Publikováno v:
Biochemistry. 44(34)
Beta-APP cleaving enzyme (BACE) is responsible for the first of two proteolytic cleavages of the APP protein that together lead to the generation of the Alzheimer's disease-associated Abeta peptide. It is widely believed that halting the production o
Autor:
Marian Kruszynski, Douglas James Riexinger, Roger P. Mcever, George Heavner, Margaret L. Falcone, Miljenko Mervic, Leon Epps
Publikováno v:
International journal of peptide and protein research. 42(5)
The selectins are a family of three structurally related glycoproteins that are integral components of leukocyte adhesion to the vascular endothelium. Their involvement in the recruitment and extravasation of neutrophils is critical in mounting an in
Autor:
Douglas James Riexinger, George Heavner, Marian Kruszynski, Leon Epps, Miljenko Mervic, Margaret L. Falcone, Rodger P. Mcever, Jian-Guo Geng
Publikováno v:
Peptides 1992 ISBN: 9789401046466
Peptides 1992
Peptides 1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ddb2b1d42eac356e843b37fc0a3ac1c
https://doi.org/10.1007/978-94-011-1470-7_361
https://doi.org/10.1007/978-94-011-1470-7_361