Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Douglas J. Swartz"'
Autor:
Ina L. Urbatsch, Douglas J. Swartz, Narong Sok, Anukriti Singh, Joshua N. Thomas, Joachim Weber
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
P-glycoprotein (Pgp) pumps an array of hydrophobic compounds out of cells, and has major roles in drug pharmacokinetics and cancer multidrug resistance. Yet, polyspecific drug binding and ATP hydrolysis-driven drug export in Pgp are poorly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b39b6facaef43f0405517fb0bd633
http://europepmc.org/articles/PMC7035247
http://europepmc.org/articles/PMC7035247
Autor:
Jiangping Bai, Douglas J Swartz, Irina I Protasevich, Christie G Brouillette, Patina M Harrell, Ellen Hildebrandt, Brigitte Gasser, Diethard Mattanovich, Andrew Ward, Geoffrey Chang, Ina L Urbatsch
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22577 (2011)
Structural and biochemical studies of mammalian membrane proteins remain hampered by inefficient production of pure protein. We explored codon optimization based on highly expressed Pichia pastoris genes to enhance co-translational folding and produc
Externí odkaz:
https://doaj.org/article/f424fe6f9d1a45adb472c97182b63619
Autor:
Nghi Tran, Ina Urbatsch, Douglas J. Swartz, Anukriti Singh, Courtney Katz, Benjamin T. Jackson, Joachim Weber
Publikováno v:
Biophysical Journal. 120:69a-70a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2eea151258d23a78dd9d503d7826b57
https://doi.org/10.1016/j.bpj.2020.11.645
https://doi.org/10.1016/j.bpj.2020.11.645
Autor:
Anukriti Singh, Ina L. Urbatsch, Gregory A. Fendley, Maria E. Zoghbi, Leo Mok, Guillermo A. Altenberg, Douglas J. Swartz
Publikováno v:
The Journal of biological chemistry, vol 292, iss 50
P-glycoprotein (Pgp) is an efflux pump important in multidrug resistance of cancer cells and in determining drug pharmacokinetics. Pgp is a prototype ATP-binding cassette transporter with two nucleotide-binding domains (NBDs) that bind and hydrolyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cc751d6378f16f80e18e39ca84b80b
https://doi.org/10.1074/jbc.m117.814186
https://doi.org/10.1074/jbc.m117.814186
Autor:
Christie G. Brouillette, Qingxian Zhou, Douglas J. Swartz, Leo Mok, Anukriti Singh, Ina L. Urbatsch, Zhengrong Yang
Publikováno v:
Biochim Biophys Acta Biomembr
Structural changes in mouse P-glycoprotein (Pgp) induced by thermal unfolding were studied by differential scanning calorimetry (DSC), circular dichroism and fluorescence spectroscopy to gain insight into the solution conformation(s) of this ABC tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ef252810d955393a0e2020018b68d0
https://doi.org/10.1016/j.bbamem.2016.10.009
https://doi.org/10.1016/j.bbamem.2016.10.009
Autor:
Joachim Weber, Courtney Katz, Anukriti Singh, Benjamin T. Jackson, Ina L. Urbatsch, Douglas J. Swartz
Publikováno v:
Biophysical Journal. 118:19a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93760c55fb9e9ae121408fb8b9fc516
https://doi.org/10.1016/j.bpj.2019.11.287
https://doi.org/10.1016/j.bpj.2019.11.287
Autor:
Joachim Weber, Douglas J. Swartz, Anukriti Singh, Courtney Katz, Sakshi Gautam, Ina L. Urbatsch
Publikováno v:
Biophysical Journal. 116:126a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f303ea72b7afe1e5d0decfdf1bf0fe22
https://doi.org/10.1016/j.bpj.2018.11.699
https://doi.org/10.1016/j.bpj.2018.11.699
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828:1159-1168
P-glycoprotein (Pgp) is an important contributor to multidrug resistance of cancer. Pgp contains eleven native tryptophans (Trps) that are highly conserved among orthologs. We replaced each Trp by a conservative substitution to determine which Trps a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc0d3a94567a0df545d057b72a05f06
https://doi.org/10.1016/j.bbamem.2012.12.005
https://doi.org/10.1016/j.bbamem.2012.12.005
Autor:
Hans Henning von Horsten, Sandra Whelly, Gail A. Cornwall, Kim M. Chau, Seethal Johnson, Douglas J. Swartz
Publikováno v:
Asian Journal of Andrology. 9:500-507
The epididymal lumen represents a unique extracellular environment because of the active sperm maturation process that takes place within its confines. Although much focus has been placed on the interaction of epididymal secretory proteins with sperm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abcedc5d290ba4e39feeb8b11b89ae4
https://doi.org/10.1111/j.1745-7262.2007.00309.x
https://doi.org/10.1111/j.1745-7262.2007.00309.x
Autor:
Guillermo A. Altenberg, Anukriti Singh, Douglas J. Swartz, Sri K. Botta, Ina L. Urbatsch, Leo Mok
Publikováno v:
Bioscience Reports, Vol 34, Iss 3, p e00116 (2014)
Bioscience Reports
Bioscience Reports
Pgp (P-glycoprotein) is a prototype ABC (ATP-binding-cassette) transporter involved in multidrug resistance of cancer. We used directed evolution to replace six cytoplasmic Cys (cysteine) residues in Pgp with all 20 standard amino acids and selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd5c63c212d3ee1f3b0200139d59985
http://www.bioscirep.org/bsr/034/e116/bsr034e116.htm
http://www.bioscirep.org/bsr/034/e116/bsr034e116.htm