Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Douglas J. Manion"'
Autor:
Michael Ernest Pierce, Jing-Tao Wu, John W. Mellors, Romas Geleziunas, Lee T. Bacheler, Michael J. Otto, Dennis C. Liotta, George L. Trainor, Hammond Jennifer, Douglas J. Manion, Sharon Diamond, Holly Bazmi, Susan Erickson-Viitanen, Hangchun Zhang, Lieven Stuyver, M. M. Rayner, Ronald M. Klabe, Sena Garber, Karen Gallagher, Raymond F. Schinazi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:1394-1401
Highly active antiretroviral therapy (HAART) is the standard treatment for infection with the human immunodeficiency virus (HIV). HAART regimens consist of protease inhibitors or nonnucleoside reverse transcriptase inhibitors combined with two or mor
Autor:
W. Jeffrey Fessel, Lynn M. Ploughman, Douglas J. Manion, David W. Haas, Dominic F. Labriola, Mark H. Kaplan, Robert Delapenha, Harold A. Kessler, Nancy Ruiz, Daniel Seekins
Publikováno v:
The Journal of Infectious Diseases. 183:392-400
A randomized, double-blind, placebo-controlled trial compared efavirenz (600 mg every 24 h) plus indinavir (1000 mg every 8 h) with placebo (every 24 h) plus indinavir (800 mg every 8 h) among 327 nucleoside analogue reverse-transcriptase inhibitor (
Autor:
David M. Kornhauser, Harold W. Lischner, Stuart E. Starr, Mark I. Becker, Bobie Graham, Richard C. Brundage, Suzanne Siminski, Stephen A. Spector, William D. Fiske, Merril Gersten, Florence H. Yong, Lynette Purdue, Wayne M. Dankner, Carol Vincent, Terence Fenton, Patricia M. Flynn, Douglas J. Manion, Nancy M. Ruiz, James McNamara, Courtney V. Fletcher, Lynne M. Mofenson
Publikováno v:
New England Journal of Medicine. 341:1874-1881
Background Consistent long-term viral suppression has been difficult to achieve in children with human immunodeficiency virus type 1 (HIV-1) infection. We tested the safety and antiviral efficacy of a novel combination consisting of efavirenz, nelfin
Autor:
Anita Rachlis, Daniel J. Skiest, James F. Stanford, Javier O Morales-Ramirez, Dominic F. Labriola, Douglas J. Manion, Schlomo Staszewski, Karen T. Tashima, Philip J. Johnson, Richard Stryker, Nancy M. Ruiz, Dianne Farina
Publikováno v:
New England Journal of Medicine. 341:1865-1873
Background Efavirenz is a nonnucleoside reverse-transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). We compared two regimens containing efavirenz, one with a protease inhibitor and the other with two nucleoside reverse-transcripta
Autor:
Martin S. Hirsch, Douglas J. Manion
Publikováno v:
The American Journal of Medicine. 102:76-80
Combination therapy approaches are becoming the mainstay of treatment for a variety of neoplastic and infectious diseases, including human immunodeficiency virus (HIV)-1 infections. The advantages of combination therapy include potentially additive-t
Publikováno v:
The Journal of infectious diseases. 176(1)
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors are a promising class of antiretroviral agents that compromise enzymatic function through substrate mimicry. The in vitro susceptibility of a panel of HIV-1 clinical isolates demonstrati