Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Douglas J. Loftus"'
Autor:
Markus Maeurer, Koji Nakano, Kazuaki Chikamatsu, Thomas K. Hoffmann, Douglas J. Loftus, Albert B. DeLeo, Theresa L. Whiteside, Ettore Appella
Publikováno v:
The Journal of Immunology. 168:1338-1347
Recently, we observed that CTL specific for the wild-type (wt) sequence p53264–272 peptide could only be expanded ex vivo from PBMC of a subset of the HLA-A2.1+ normal donors or cancer patients tested. Surprisingly, the tumors of the responsive pat
Autor:
Douglas J. Loftus, Mohamed Saad, Debora Donnini, Rui Zhao, Edward J. Collins, Jennifer Buslepp, Ettore Appella
Publikováno v:
Journal of Biological Chemistry. 276:47320-47328
Recognition of virally infected cells by CD8+ T cells requires differentiation between self and nonself peptide-class I major histocompatibility complexes (pMHC). Recognition of foreign pMHC by host T cells is a major factor in the rejection of trans
Autor:
Haakon Ragde, Gerald P. Murphy, Alton L. Boynton, Mary Rogers, Joanne G. McLean, G.M. Kenny, Ben A. Tjoa, Douglas J. Loftus, Michael L. Salgaller, Patricia A. Lodge
Publikováno v:
The Prostate. 35:144-151
BACKGROUND In this paper we describe our program for the immune monitoring of phase II participants given dendritic cell (DC)/prostate-specific membrane antigen (PSMA)-based immunotherapy, and we also present some initial findings. METHODS Phase II s
Autor:
Chiara Castelli, Ettore Appella, Timothy M. Clay, Licia Rivoltini, Paola Squarcina, Giorgio Parmiani, Michael I. Nishimura, Francesco M. Marincola, Douglas J. Loftus
Publikováno v:
The Journal of Experimental Medicine
CTL reactivity to the epitope MART-1(27-35), of the melanoma (self) antigen MART-1/melan A is frequently observed in tumor-infiltrating lymphocytes and may be readily elicited from the peripheral blood of melanoma patients that express HLA-A*0201. Av
Publikováno v:
Scopus-Elsevier
We have constructed a recombinant single-chain human HLA-A2.1 molecule (from A*0201) with a covalently attached beta 2m. This molecule (MSC beta A2.1) can be detected on the surface of transfected beta 2m- human cells by conformational antibodies W6/
Autor:
F di Marzo Veronese, Vincenzo Barnaba, J. Shabanowitz, C B Thompson, Claudio Maria Mastroianni, Douglas J. Loftus, E Appella, A Sette, Donald F. Hunt, Kazuyasu Sakaguchi, Simonetta Salemi, David Arnott
Publikováno v:
The Journal of Experimental Medicine
A subtractive analysis of peptides eluted from major histocompatibility complex (MHC) class I human histocompatibility leukocyte antigen (HLA)-A2.1 molecules purified from either human immunodeficiency virus type-1 (HIV-1)-infected or uninfected cell
Autor:
Niels Ødum, Mogens Holst Nissen, Douglas J. Loftus, Mai Britt Nielsen, Alexei F. Kirkin, Jesper Zeuthen, Licia Rivoltini, Carsten Geisler
Publikováno v:
University of Copenhagen
Single amino acid substitutions in melanoma-associated peptides dramatically enhance T-cell cytotoxicity against target cells presenting the modified peptides (often referred to as heteroclitic peptides). The authors tried to determine whether peptid
Publikováno v:
The Journal of Experimental Medicine
The T cell receptor (TCR), from a xeno-reactive murine cytotoxic T lymphocyte clone AHIII12.2, recognizes murine H-2Db complexed with peptide p1027 (FAPGVFPYM), as well as human HLA-A2.1 complexed with peptide p1049 (ALWGFFPVL). A commonly proposed m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70302128ac6e5a2b0411fec616d10b5
Autor:
Steven A. Rosenberg, Ettore Appella, Yutaka Kawakami, Douglas J. Loftus, Yong F. Li, Mona El-Gamil, Paul F. Robbins
Publikováno v:
The Journal of Experimental Medicine
A number of antigens recognized by tumor-reactive T cells have recently been identified. The antigens identified in mouse model systems appear, with one exception, to represent the products of mutated genes. In contrast, most of the antigens recogniz
Autor:
Esteban Celis, Ralph T. Kubo, Kazuyasu Sakaguchi, Alessandro Sette, Douglas J. Loftus, Ettore Appella
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461357711
Vertebrate immune responses hinge on T cell receptor (TCR)-mediated recognition of antigenic peptides bound to polymorphic class I and class II molecules of the Major Histocompatibility Complex (MHC). The polymorphism that exists at MHC class I and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67df76258752f75bcc199c246602dff3
https://doi.org/10.1007/978-1-4615-1891-4_21
https://doi.org/10.1007/978-1-4615-1891-4_21