Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Douglas J. Guarnieri"'
Autor:
Richard Trinko, Geliang Gan, Xiao-Bing Gao, Robert M Sears, Douglas J Guarnieri, Ralph J DiLeone
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27180 (2011)
Leptin acts on the ventral tegmental area (VTA) to modulate neuronal function and feeding behavior in rats and mice. To identify the intracellular effectors of the leptin receptor (Lepr), downstream signal transduction events were assessed for regula
Externí odkaz:
https://doaj.org/article/a9b0b9f4e7c645de9baa7fb3dd6a4696
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22867 (2011)
The genetic mechanisms that influence memory formation and sensitivity to the effects of ethanol on behavior in Drosophila have some common elements. So far, these have centered on the cAMP/PKA signaling pathway, synapsin and fas2-dependent processes
Externí odkaz:
https://doaj.org/article/519be8e639454493a098d92d597a9c7b
Publikováno v:
Pharmacology Biochemistry and Behavior. 122:37-52
In several animal species including humans, the acute administration of low doses of alcohol increases motor activity. Different theories have postulated that alcohol-induced hyperactivity is causally related to alcoholism. Moreover, a common biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c87ba8e996e6be15ce90c4146dcdc9
https://doi.org/10.1016/j.pbb.2014.03.006
https://doi.org/10.1016/j.pbb.2014.03.006
Autor:
Cliff H. Summers, Douglas J. Guarnieri, Justin K. Achua, Hao Li, Ralph J. DiLeone, James E. Hassell, David H. Arendt, Patrick J. Ronan
Publikováno v:
Psychoneuroendocrinology. 40:17-26
The orexin/hypocretin system interacts with many of the same circuitries contributing to stress-associated disorders like depression and anxiety. These include potentially reciprocal connections with corticotropin releasing factor (CRF) neurons which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fda6b01a5b85126321be8fbb1361416
https://doi.org/10.1016/j.psyneuen.2013.10.010
https://doi.org/10.1016/j.psyneuen.2013.10.010
Autor:
Ralph J. DiLeone, David M Grimaldi, Douglas J. Guarnieri, Maysa Sarhan, Nandakumar S. Narayanan, Karl Deisseroth, Rong-Jian Liu, Catherine E. Brayton, Carol A. Gianessi, Benjamin B. Land, George K. Aghajanian
Publikováno v:
Nature neuroscience
Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c51561cd745e6f2e1780c907ce858
http://europepmc.org/articles/PMC3968853
http://europepmc.org/articles/PMC3968853
Autor:
Shiru Zhao, Scott E. Kanoski, Matthew R. Hayes, Bart C. De Jonghe, Jianqun Yan, Harvey J. Grill, Kendra K. Bence, Douglas J. Guarnieri, Ralph J. DiLeone
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E496-E503
Leptin receptor (LepRb) signaling in the hindbrain is required for energy balance control. Yet the specific hindbrain neurons and the behavioral processes mediating energy balance control by hindbrain leptin signaling are unknown. Studies here employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039144bae328984a9e0b5771fea2b43f
https://doi.org/10.1152/ajpendo.00205.2012
https://doi.org/10.1152/ajpendo.00205.2012
Autor:
Jane R. Taylor, Ralph J. DiLeone, Joseph R. Trinko, Sarah M. Richards, Jaime G. Maldonado-Avilés, Jessica C. Nelson, Douglas J. Guarnieri, Catherine E. Brayton, Shannon L. Gourley
Publikováno v:
Biological Psychiatry. 71:358-365
Background Food restriction is known to enhance learning and motivation. The neural mechanisms underlying these responses likely involve alterations in gene expression in brain regions mediating the motivation to feed. Methods Analysis of gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71c4998dcea4552c99504776ea984a9
https://doi.org/10.1016/j.biopsych.2011.06.028
https://doi.org/10.1016/j.biopsych.2011.06.028
Autor:
Ulrike Heberlein, Kimberly D. McClure, Fred W. Wolf, Mark Eddison, Ammon B. Corl, Anita V. Devineni, Douglas J. Guarnieri
Publikováno v:
Fly. 5:191-199
The relationship between alcohol consumption, sensitivity, and tolerance is an important question that has been addressed in humans and rodent models. Studies have shown that alcohol consumption and risk of abuse may correlate with (1) increased sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f9e305506eedb60e708871a8890272
https://doi.org/10.4161/fly.5.3.16987
https://doi.org/10.4161/fly.5.3.16987
Autor:
Kevin G. Moffat, Ulrike Heberlein, Che-Hsiung Liu, Mark Eddison, Graeme Ph D. Davis, Douglas J. Guarnieri, Ling Cheng
Publikováno v:
Neuron. 70:979-990
SummaryA reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol sedation mutants in Drosophila identified arouser (aru), which functions in developing neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1da7251f0e312e4e7a0558780c97437
https://doi.org/10.1016/j.neuron.2011.03.030
https://doi.org/10.1016/j.neuron.2011.03.030
Autor:
Soeren Diegelmann, Troy Zars, Ulrike Heberlein, Divya Sitaraman, Holly LaFerriere, Douglas J. Guarnieri
Publikováno v:
Genetics. 178:1895-1902
The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c33fbfa828804d99cb7de484ee014d
https://doi.org/10.1534/genetics.107.084582
https://doi.org/10.1534/genetics.107.084582