Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Douglas J. E. Elder"'
Autor:
Emma E Vincent, Douglas J E Elder, Linda O'Flaherty, Olivier E Pardo, Piotr Dzien, Lois Phillips, Carys Morgan, Joya Pawade, Margaret T May, Muhammad Sohail, Martin R Hetzel, Michael J Seckl, Jeremy M Tavaré
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114725 (2014)
Glycogen synthase kinase 3 (GSK3) is a central regulator of cellular metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis, yet recent studies indicate that it may support tumour growth in some cancer types including
Externí odkaz:
https://doaj.org/article/e50111a30fc64073850e7a917f9519fe
Autor:
Emma E Vincent, Douglas J E Elder, Jon Curwen, Elaine Kilgour, Ingeborg Hers, Jeremy M Tavaré
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66963 (2013)
Phase III trials of the anti-insulin-like growth factor-1 receptor (IGF1R) antibody figitumumab in non-small cell lung cancer (NSCLC) patients have been discontinued owing to lack of survival benefit. We investigated whether inhibition of the highly
Externí odkaz:
https://doaj.org/article/0d0a283a10cf44a098432bfcc71767ff
Autor:
Joya Pawade, Douglas J. E. Elder, Muhammed Sohail, Margaret T May, Emma E. Vincent, Lois Phillips, Jeremy M. Tavaré, C. Morgan, Martin R. Hetzel, Elaine C. Thomas
Publikováno v:
British Journal of Cancer
Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells. Akt activation involves the phosphorylation of two residues: threonine 308 (Thr308) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38172bc5d9b4cde7073ce917c07f3a25
https://doi.org/10.1038/bjc.2011.132
https://doi.org/10.1038/bjc.2011.132
Autor:
Douglas J. E. Elder, Alexey Sergushichev, Thierry Ntimbane, Ekaterina Loginicheva, Emma E. Vincent, Gaëlle Bridon, Takla Griss, Elaine C. Thomas, Luc Choinière, Arnim Pause, Breanna R. Flynn, Maxim N. Artyomov, Bozena Samborska, Thomas C. Raissi, Julianna Blagih, Jeremy M. Tavaré, Daina Avizonis, Russell G. Jones, Paula P. Coelho, Marie-Claude Gingras
Publikováno v:
Vincent, E E, Sergushichev, A, Griss, T, Gingras, M C, Samborska, B, Ntimbane, T, Coelho, P P, Blagih, J, Raissi, T C, Choinière, L, Bridon, G, Loginicheva, E, Flynn, B R, Thomas, E C, Tavaré, J M, Avizonis, D, Pause, A, Elder, D J E, Artyomov, M N & Jones, R G 2015, ' Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth ', Molecular Cell, vol. 60, no. 2, pp. 195-207 . https://doi.org/10.1016/j.molcel.2015.08.013
Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used combined transcriptional-metabolomic network analysis to identify metabolic pathways that support glucose-independent tumor cell proliferation. We found that gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de91fd519ddc9d2f66102d7d42f6e761
https://research-information.bris.ac.uk/en/publications/7e24d67e-0600-4212-93d4-3bd1a2f4a636
https://research-information.bris.ac.uk/en/publications/7e24d67e-0600-4212-93d4-3bd1a2f4a636
Publikováno v:
British Journal of Cancer
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit colorectal neoplasia, an effect that is associated with their ability to induce apoptosis. Although NSAIDs have been reported to inhibit NF-kappaB, more recent studies show activation of NF-kappaB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee000e31b4053f5be943b6a741fa929
https://doi.org/10.1038/sj.bjc.6601266
https://doi.org/10.1038/sj.bjc.6601266
Publikováno v:
International Journal of Cancer. 99:323-327
Nonsteroidal antiinflammatory drugs (NSAIDs) can prevent colorectal tumorigenesis in humans and in rodents. In vitro and in vivo studies indicate that one of their principal antineoplastic avenues is the induction of apoptosis. We have shown previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861bfa875324a7dbe329dfb881a74b6f
https://doi.org/10.1002/ijc.10330
https://doi.org/10.1002/ijc.10330
Publikováno v:
The Journal of Pathology. 198:428-434
Non-steroidal anti-inflammatory drugs are chemopreventive for colorectal cancer. This effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX-2). However, the cellular expression and role of COX-2 in the premali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96695fc2a97023c3d6a6659d50ca7971
https://doi.org/10.1002/path.1232
https://doi.org/10.1002/path.1232
Publikováno v:
International Journal of Cancer. 86:553-560
We determined the effect of the highly selective cyclooxygenase-2 (COX-2) inhibitor NS-398 on proliferation, apoptosis and COX-2 regulation in 3 pre-malignant human colorectal adenoma cell lines (RG/C2, AA/C1, RR/C1) and compared its effect on 3 colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41fb4540623adfb8f0b6ac60a246ce89
https://doi.org/10.1002/(sici)1097-0215(20000515)86:4<553::aid-ijc18>3.0.co
https://doi.org/10.1002/(sici)1097-0215(20000515)86:4<553::aid-ijc18>3.0.co
Publikováno v:
International Journal of Cancer. 60:400-406
The short chain fatty acids acetate, propionate and butyrate are produced when dietary fibre is fermented by the colonic bacteria. We have previously shown that sodium butyrate induces apoptosis in 3 colorectal tumour cell lines. We have extended our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6604a033e33d635c9c19730d21aa39fa
https://doi.org/10.1002/ijc.2910600322
https://doi.org/10.1002/ijc.2910600322
Autor:
Emma E, Vincent, Douglas J E, Elder, Lois, Phillips, Kate J, Heesom, Joya, Pawade, Michael, Luckett, Mohammed, Sohail, Margaret T, May, Martin R, Hetzel, Jeremy M, Tavaré
Publikováno v:
Anticancer research. 31(5)
Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3ec4733fb489e1d782a22058acd626e
https://pubmed.ncbi.nlm.nih.gov/21617212
https://pubmed.ncbi.nlm.nih.gov/21617212