Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Douglas J Macneil"'
Autor:
Douglas J MacNeil
Publikováno v:
Frontiers in Endocrinology, Vol 4 (2013)
Extensive studies in rodents with melanin-concentrating hormone (MCH) have demonstrated that the neuropeptide hormone is a potent orexigen. Acutely, MCH causes an increase in food intake, while chronically it leads to increased weight gain, primarily
Externí odkaz:
https://doaj.org/article/e03ac5d9ee91400cabfdea5f4ffe3a15
Autor:
Hua Zhong, John Beaulaurier, Pek Yee Lum, Cliona Molony, Xia Yang, Douglas J Macneil, Drew T Weingarth, Bin Zhang, Danielle Greenawalt, Radu Dobrin, Ke Hao, Sangsoon Woo, Christine Fabre-Suver, Su Qian, Michael R Tota, Mark P Keller, Christina M Kendziorski, Brian S Yandell, Victor Castro, Alan D Attie, Lee M Kaplan, Eric E Schadt
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000932 (2010)
Genome-wide association studies (GWAS) have demonstrated the ability to identify the strongest causal common variants in complex human diseases. However, to date, the massive data generated from GWAS have not been maximally explored to identify true
Externí odkaz:
https://doaj.org/article/ce5771819e0c48389a04a2ee9678fe6e
Autor:
Joe Clemas, Jerry Andrew Taylor, Feroze Ujjainwalla, Jim Tata, Doris F. Cully, Tom Wisniewski, Wei Tang, Charlene Bopp, Clare London, Andreas Verras, Scott B. Hoyt, Andrea Sok, Elaine Tung, Douglas J. MacNeil, Gaochao Zhou, Amjad Ali, Qing Chen, Gino Salituro, Yusheng Xiong, Daniel R. McMasters, Mary Struthers, Ning Ren, Ruth A. Duffy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2384-2388
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9a114775b2eff2c4ce3ec96aa4668
https://doi.org/10.1016/j.bmcl.2017.04.021
https://doi.org/10.1016/j.bmcl.2017.04.021
Autor:
Brent R. Whitehead, Michael M.-C. Lo, Amjad Ali, Min K. Park, Scott B. Hoyt, Yusheng Xiong, Jiaqiang Cai, Emma Carswell, Andrew Cooke, John MacLean, Paul Ratcliffe, John Robinson, D. Jonathan Bennett, Joseph A. Clemas, Tom Wisniewski, Mary Struthers, Doris Cully, Douglas J. MacNeil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:143-146
This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3f370cc26a7dc473d889e2fc7da4ea
https://doi.org/10.1016/j.bmcl.2016.12.003
https://doi.org/10.1016/j.bmcl.2016.12.003
Autor:
Feroze Ujjainwalla, Charlene Bopp, Carrie Ann Shipley, Yusheng Xiong, Mary Struthers, Bindhu V. Karanam, Clare London, Gaochao Zhou, Ning Ren, Andreas Verras, Andrea Sok, Amjad Ali, Qing Chen, Doris F. Cully, Joseph Clemas, Jack Gibson, James R. Tata, Daniel R. McMasters, Ying Li, Whitney Lane Petrilli, Scott B. Hoyt, Elaine Tung, Ian Knemeyer, Ruth A. Duffy, Wei Tang, Thomas Wisniewski, Douglas J. MacNeil, Gino Salituro
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd54739c1d66c5903e38d15b799bee69
https://pubmed.ncbi.nlm.nih.gov/28105288
https://pubmed.ncbi.nlm.nih.gov/28105288
Autor:
Marc L. Reitman, Ann E. Weber, Douglas J. MacNeil, Alison M. Strack, Liping Wang, Drew T. Weingarth, Jie Pan, Susan J. Lee, Scott D. Edmondson, Su Qian, James Hubert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2911-2915
A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e404299f5f1bca8802c531b821e538c
https://doi.org/10.1016/j.bmcl.2011.03.069
https://doi.org/10.1016/j.bmcl.2011.03.069
Autor:
H Matsushita, Makoto Ito, H Iwaasa, Akio Kanatani, Masahiko Ito, Akane Ishihara, Joseph M. Metzger, Donald J. Marsh, Akira Gomori, Yuji Haga, M Moriya, S Tokita, N Takenaga, Nagaaki Sato, Douglas J. MacNeil
Publikováno v:
British Journal of Pharmacology. 159:374-383
Background and purpose: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide expressed in the lateral hypothalamus that is involved in feeding and body weight regulation. Intracerebroventricular infusion of a peptidic MCH1 receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ca982cfee114cae2a44d78ff4fd97c
https://doi.org/10.1111/j.1476-5381.2009.00536.x
https://doi.org/10.1111/j.1476-5381.2009.00536.x
Autor:
Margarete Mehrabian, Sana Majid, Aldons J. Lusis, Tao Xie, Pek Yee Lum, Daria Estrada-Smith, Lawrence W. Castellani, Thomas A. Drake, Robert R. Kleinhanz, Anatole Ghazalpour, Gevork Torosyan, Jun Zhu, Joshua L. Deignan, Eric E. Schadt, Su Qian, Kai Wang, Katrina M. Dipple, Jenny C Karlsson, Douglas J. MacNeil, Xia Yang, Judy Zhong, Charles R. Farber, Marc L. Reitman, Bin Zhang, Michael Coon, Chunsheng Zhang, Susanna S. Wang, John Lamb, Hongxiu Qi, Sheena Mumick, Atila van Nas, Brie Falkard
Publikováno v:
Nature genetics, vol 41, iss 4
A principal task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a8962f681de249ed5b3c77814e0b6e
https://doi.org/10.1038/ng.325
https://doi.org/10.1038/ng.325
Autor:
Michael R. Tota, Su Qian, Peter Nizner, Sheena Mumick, Joseph Menetski, Marc L. Reitman, Douglas J. MacNeil
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 103:36-42
Cytosolic malic enzyme (ME-1) is a nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzyme that generates NADPH. The activity of this enzyme, the reversible oxidative decarboxylation of malate to yield pyruvate, links glycolytic pathway t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1e0d9a14399ca5b91a7072761b7b93
https://doi.org/10.1111/j.1742-7843.2008.00228.x
https://doi.org/10.1111/j.1742-7843.2008.00228.x
Autor:
Akio Kanatani, Lex H.T. Van der Ploeg, Akira Gomori, Toshiyuki Takahashi, Junko Ito, Akane Ishihara, Ryuichi Moriya, Hiroko Matsushita, Hidefumi Kitazawa, Satoshi Mashiko, Hisashi Iwaasa, Yuko Mitobe, Douglas J. MacNeil, Takehiro Fukami
Publikováno v:
Obesity. 16:1510-1515
Objective: To further address the function of the Y5 receptor in energy homeostasis, we investigated the effects of a novel spironolactone Y5 antagonist in diet-induced obese (DIO) mice. Methods and Procedures: Male C57BL/6 or Npy5r−/− mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88837af7b9c8206207e0da799c89f340
https://doi.org/10.1038/oby.2008.223
https://doi.org/10.1038/oby.2008.223