Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Douglas J Goetz"'
Autor:
Grady E Carlson, Eric W Martin, Venktesh S Shirure, Ramiro Malgor, Vicente A Resto, Douglas J Goetz, Monica M Burdick
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173747 (2017)
A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostain
Externí odkaz:
https://doaj.org/article/1970e58a379a4274939fab68ebbcf6c9
Autor:
Davoud Ghazanfari, Maria Cecilia Courreges, Lydia E. Belinski, Michael J. Hogrell, Jacob Lloyd, Stephen C. Bergmeier, Kelly D. McCall, Douglas J. Goetz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract During a SARS-CoV-2 infection, macrophages recognize viral components resulting in cytokine production. While this response fuels virus elimination, overexpression of cytokines can lead to severe COVID-19. Previous studies suggest that the s
Externí odkaz:
https://doaj.org/article/56233cae8bb2417da30fac712d7f764f
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Cell adhesion mediated by selectins (expressed by activated endothelium, activated platelets, and leukocytes) binding to their resepective selectin ligands (expressed by cancer cells) may be involved in metastasis. Therefore, methods of char
Externí odkaz:
https://doaj.org/article/dc292edf5a4e49d8ac0208b3dfa32f21
Autor:
Davoud Ghazanfari, Maria Cecilia Courreges, Lydia Belinski, Stephen C. Bergmeier, Kelly D. McCall, Douglas J. Goetz
Publikováno v:
Biochemical and Biophysical Research Communications. 605:171-176
A key component of severe COVID-19 is a "cytokine storm" i.e., the excessive expression of unneeded cytokines. Previous studies suggest that SARS-CoV-2 proteins can induce macrophages to secrete pro-inflammatory cytokines; a process that may involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b179c5e64dfc71c32e66a445c274d71e
https://doi.org/10.1016/j.bbrc.2022.03.035
https://doi.org/10.1016/j.bbrc.2022.03.035
Autor:
Melissa R. Kauffman, Kelly D. McCall, Nathan M. Reynolds, Ahmed Faik, Monica M. Burdick, Saeed Nazemidashtarjandi, Abigail E. Allen, Davoud Ghazanfari, Douglas J. Goetz
Publikováno v:
Leuk Res
The role of interferon-gamma (IFN-γ) in Chronic Myelogenous/Myeloid Leukemia (CML) and in the treatment of CML remains unclear; specifically, the effect of IFN-γ on apoptosis. There is reported interplay between IFN-γ and glycogen synthase kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193520c2784fae23951c6bdc64e50a89
https://europepmc.org/articles/PMC7740760/
https://europepmc.org/articles/PMC7740760/
Autor:
Maria C. Courreges, Stephen C. Bergmeier, Douglas J. Goetz, Mahboubeh S. Noori, Kelly D. McCall
Publikováno v:
European Journal of Pharmacology
Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. a cytokine storm. For sepsis involving gram-negative b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7067b2d85f1727a504b39a152e9129
https://pubmed.ncbi.nlm.nih.gov/32634441
https://pubmed.ncbi.nlm.nih.gov/32634441
Autor:
Tyler Church, Edward O. List, Kelly D. McCall, Frank L. Schwartz, Douglas J. Goetz, Ashley Patton, Caroline Wilson, Darlene E. Berryman, Jean R. Thuma
Publikováno v:
The Journal of Endocrinology
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of both metabolic and inflammatory diseases and has become the leading chronic liver disease worldwide. High-fat (HF) diets promote an increased uptake and storage of free fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a48b9815fe0cb15f1d41a4ca4a6fa65
http://europepmc.org/articles/PMC5958349
http://europepmc.org/articles/PMC5958349
Autor:
Frank L. Schwartz, Monica M. Burdick, Mahboubeh S. Noori, Zachary J. Champa, Kelly D. McCall, Douglas J. Goetz, Chunyan Qi, Sudhir P. Deosarkar, John D. O'Brien, Stephen C. Bergmeier, Olivia L. Lanier
Publikováno v:
European Journal of Pharmacology. 803:130-137
Inhibition of interleukin–6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d94dfae1b3cdef3a16677d5b100adb
https://doi.org/10.1016/j.ejphar.2017.03.049
https://doi.org/10.1016/j.ejphar.2017.03.049
Autor:
Evan S Streator, Monica M. Burdick, Sarah J. Bodle, Mahboubeh S. Noori, Christian A. Showalter, Douglas J. Goetz, David Drozek
Publikováno v:
Cell Mol Bioeng
Cancers of the digestive tract cause nearly one quarter of the cancer deaths worldwide, and nearly half of these are due to cancers of the esophagus and colon. Early detection of cancer significantly increases the rate of survival, and thus it is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfece77313b0d41db8ccac3c1c4cb32e
https://europepmc.org/articles/PMC7048886/
https://europepmc.org/articles/PMC7048886/
Autor:
Kelly D. McCall, Mahboubeh S. Noori, Crina M. Orac, Mark C. McMills, Chaz M. Cuckler, Douglas J. Goetz, Davoud Ghazanfari, Maria C. Courreges, Stephen C. Bergmeier, Pooja Bhatt, Sudhir P. Deosarkar, Frank L. Schwartz
Publikováno v:
Am J Physiol Cell Physiol
Glycogen synthase kinase-3 (GSK-3) is a multitasking protein kinase that regulates numerous critical cellular functions. Not surprisingly, elevated GSK-3 activity has been implicated in a host of diseases including pathological inflammation, diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e29daaf893a4d9735b603a248ac5e99
https://pubmed.ncbi.nlm.nih.gov/31553649
https://pubmed.ncbi.nlm.nih.gov/31553649