Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Douglas J Cook"'
Autor:
Callum Stephenson, Niloufar Malakouti, Joseph Y Nashed, Tim Salomons, Douglas J Cook, Roumen Milev, Nazanin Alavi
Publikováno v:
JMIR Research Protocols, Vol 10, Iss 9, p e30726 (2021)
BackgroundObsessive-compulsive disorder (OCD) is a debilitating and prevalent anxiety disorder. Although the basal ganglia and frontal cortex are the brain regions that are most commonly hypothesized to be involved in OCD, the exact pathophysiology i
Externí odkaz:
https://doaj.org/article/7fc557785ddc404aa1663e68918a9f69
Publikováno v:
Brain Circulation, Vol 5, Iss 4, Pp 160-168 (2019)
Stroke accounts for a large proportion of global mortality and morbidity. Selective hypothermia, via intranasal cooling devices, is a promising intervention in acute ischemic stroke. However, prior to large clinical trials, preclinical studies in lar
Externí odkaz:
https://doaj.org/article/481949c5b5274fedba7ca4a6dd29ebdf
Publikováno v:
eLife, Vol 8 (2019)
Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does
Externí odkaz:
https://doaj.org/article/82ab4030ba9e4f948b6a17b906172059
Autor:
Vickie B. Shim, Samantha Holdsworth, Allen A. Champagne, Nicole S. Coverdale, Douglas J. Cook, Tae-Rin Lee, Alan D. Wang, Shaofan Li, Justin W. Fernandez
Publikováno v:
IEEE Access, Vol 8, Pp 179457-179465 (2020)
Mild traumatic brain injury (mTBI) is a significant issue worldwide. Public awareness of the dangers of mTBI has increased sharply in recent years, yet there is no easy-to-use tool available for early detection and post injury management. Computation
Externí odkaz:
https://doaj.org/article/b638ec3ad0c34e17b9da958d91f7bd1c
Autor:
Emma L. Robertson, Susan E. Boehnke, Natalia de M. Lyra e Silva, Brittney Armitage‐Brown, Andrew Winterborn, Douglas J. Cook, Fernanda G. De Felice, Douglas P. Munoz
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Monkeys are becoming important translational models of neurodegenerative disease. To facilitate model development, we measured cerebrospinal fluid (CSF) concentrations of key biomarkers in healthy male and female cynomolgus and rhesus macaqu
Externí odkaz:
https://doaj.org/article/155a5eaa623f424d8f6ccf0e233dd24d
Autor:
Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Ron Levy, Douglas J. Cook, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
Publikováno v:
NeuroImage, Vol 231, Iss , Pp 117830- (2021)
Changes in resting-state functional connectivity (rs-FC) under general anesthesia have been widely studied with the goal of identifying neural signatures of consciousness. This work has commonly revealed an apparent fragmentation of whole-brain netwo
Externí odkaz:
https://doaj.org/article/a76c38f0abcc430fa33ed236ed373f4b
Autor:
Susan E. Boehnke, Emma L. Robertson, Brittney Armitage‐Brown, Robert G. Wither, Natalia M. Lyra e Silva, Andrew Winterborn, Ron Levy, Douglas J. Cook, Fernanda G. De Felice, Douglas P. Munoz
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Neurofilament light (NFL) in cerebrospinal fluid (CSF) is elevated in neurodegenerative disease patients, and may track disease progression and treatment. Macaque monkeys are emerging as important translational models of neurode
Externí odkaz:
https://doaj.org/article/5c75f2b6af3a4381bf5c9d6d0d9e9e07
Autor:
Carlos R. Hernandez-Castillo, Joseph Y. Nashed, Juan Fernandez-Ruiz, Justin Wang, Jason Gallivan, Douglas J. Cook
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Here we characterized the functional connectivity (FC) changes occurring after a controlled MCA stroke in a primate model. We hypothesize that if FC can inform about the neural changes after a stroke in the non-human primate (NHP) stroke mod
Externí odkaz:
https://doaj.org/article/5dfe2f337b6c447b832d951b5ad58d0d
Autor:
Callum Stephenson, Niloufar Malakouti, Joseph Y. Nashed, Tim Salomons, Douglas J. Cook, Roumen Milev, Nazanin Alavi
Publikováno v:
Frontiers in Psychiatry. 14
BackgroundObsessive–compulsive disorder (OCD) is a debilitating mental health disorder with current psychotherapeutic treatments, while somewhat effective, yielding low accessibility and scalability. A lack of knowledge regarding the neural patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9787ab984a23fc3581942243dfa48dc
https://doi.org/10.3389/fpsyt.2023.1050530
https://doi.org/10.3389/fpsyt.2023.1050530
Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing
Autor:
Lorelei D. Shoemaker, Michael J. Clark, Anil Patwardhan, Gemma Chandratillake, Sarah Garcia, Rong Chen, Alexander A. Morgan, Nan Leng, Scott Kirk, Richard Chen, Douglas J. Cook, Michael Snyder, Gary K. Steinberg
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 1, Pp 41-49 (2016)
Moyamoya disease (MMD) is a rare disorder characterized by cerebrovascular occlusion and development of hemorrhage-prone collateral vessels. Approximately 10–12% of cases are familial, with a presumed low penetrance autosomal dominant pattern of in
Externí odkaz:
https://doaj.org/article/b8e4c8ec6df84ba1a2dc5c4670dd6173