Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Douglas J Brusich"'
1
Akademický článek
Expansion of a fly TBI model to four levels of injury severity reveals synergistic effects of repetitive injury for moderate injury conditions
Autor: Lauren J Putnam, Ashley M Willes, Brooke E Kalata, Nathaniel D Disher, Douglas J Brusich
Publikováno v: Fly, Vol 13, Iss 1-4, Pp 1-11 (2019)
Several million traumatic brain injury (TBI) events are reported in the United States annually. However, mild TBI events often go unreported, and mild and repetitive mild TBI conditions are challenging to model. Fruit flies (Drosophila melanogaster)
Externí odkaz: https://doaj.org/article/519240ecc813424a8906f394eb13329c
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2
Akademický článek
Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway.
Autor: Douglas J Brusich, Ashlyn M Spring, Thomas D James, Catherine J Yeates, Timothy H Helms, C Andrew Frank
Publikováno v: PLoS Genetics, Vol 14, Iss 8, p e1007577 (2018)
Gain-of-function mutations in the human CaV2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substi
Externí odkaz: https://doaj.org/article/8e84afdcc7674cc9a7d61507fc3ce816
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3
Akademický článek
C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
Autor: Ashlyn M Spring, Douglas J Brusich, C Andrew Frank
Publikováno v: PLoS Genetics, Vol 12, Iss 2, p e1005886 (2016)
Forms of homeostatic plasticity stabilize neuronal outputs and promote physiologically favorable synapse function. A well-studied homeostatic system operates at the Drosophila melanogaster larval neuromuscular junction (NMJ). At the NMJ, impairment o
Externí odkaz: https://doaj.org/article/81e0230539fd4423b895b36ce8a1600e
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4
Fruit flies subjected to TBI exhibit genotype-dependent changes in seizure incidence and duration
Autor: Tori R Krcmarik, Ashley M Willes, A Yang, Sydney L Weber, Douglas J Brusich
Traumatic brain injury (TBI) is common and often debilitating. One complication following TBI is post-traumatic seizures (PTS). However, there is a poor understanding of PTS, in part, because it is challenging to model. We sought to develop a fly mod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1beaf92726eae6195eae00b125b14d36
https://doi.org/10.1101/2021.10.26.465914
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6
Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway
Autor: Douglas J Brusich, Thomas D. James, Ashlyn M. Spring, Timothy H. Helms, C. Andrew Frank, Catherine J. Yeates
Gain-of-function mutations in the human CaV2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afa289e63554deee5d9ba76c598891a6
https://doi.org/10.1101/141366
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7
C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction
Autor: C. Andrew Frank, Ashlyn M. Spring, Douglas J. Brusich
Publikováno v: PLoS Genetics, Vol 12, Iss 2, p e1005886 (2016)
PLoS Genetics
Forms of homeostatic plasticity stabilize neuronal outputs and promote physiologically favorable synapse function. A well-studied homeostatic system operates at the Drosophila melanogaster larval neuromuscular junction (NMJ). At the NMJ, impairment o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3314bc1d32895dfc6c18e68bb8172a9b
http://europepmc.org/articles/PMC4764653?pdf=render
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8
Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway
Autor: C. Andrew Frank, Ashlyn M. Spring, Douglas J. Brusich, Timothy H. Helms, Thomas D. James, Catherine J. Yeates
Publikováno v: PLoS Genetics
PLoS Genetics, Vol 14, Iss 8, p e1007577 (2018)
Gain-of-function mutations in the human CaV2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9927de23c394e9c5fcc523b87ea75189
https://doi.org/10.1371/journal.pgen.1007577
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9
A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity
Autor: Douglas J. Brusich, Ashlyn M. Spring, C. Andrew eFrank
Publikováno v: Frontiers in Cellular Neuroscience, Vol 9 (2015)
Frontiers in Cellular Neuroscience
Homeostatic synaptic plasticity (HSP) helps neurons and synapses maintain physiologically appropriate levels of output. The fruit fly Drosophila melanogaster larval neuromuscular junction (NMJ) is a valuable model for studying HSP. Here we introduce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34835d6adbf15eff15a63cdc63189f78
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00107/full
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