Výsledky vyhledávání - "Douglas J Botkin"

Akademický článek

Development of a multiplex PCR assay for detection of Shiga toxin-producing Escherichia coli, Enterohemorrhagic E. coli and Enteropathogenic E. coli strains

Autor: Douglas J Botkin, Lucia eGalli, Vinoth eSankarapani, Michael eSoler, Marta eRivas, Alfredo G Torres

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)

Escherichia coli O157:H7 and other pathogenic E. coli strains are enteric pathogens associated with food safety threats and which remain a significant cause of morbidity and mortality worldwide. In the current study, we investigated whether enterohem

Externí odkaz: https://doaj.org/article/ac37e8fdb9724b9ea87d9b8df7c5fae3

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Akademický článek

Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection.

Autor: Loïc Coutte, Douglas J Botkin, Lihui Gao, Steven J Norris

Publikováno v: PLoS Pathogens, Vol 5, Iss 2, p e1000293 (2009)

Lyme disease Borrelia can infect humans and animals for months to years, despite the presence of an active host immune response. The vls antigenic variation system, which expresses the surface-exposed lipoprotein VlsE, plays a major role in B. burgdo

Externí odkaz: https://doaj.org/article/63258b65cec943088881feee1168e2f8

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Nanopore DNA Sequencing and Genome Assembly on the International Space Station

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific reports, vol 7, iss 1

The emergence of nanopore-based sequencers greatly expands the reach of sequencing into low-resource field environments, enabling in situ molecular analysis. In this work, we evaluated the performance of the MinION DNA sequencer (Oxford Nanopore Tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cabca0082224165adef4f0dfdac69be
https://doi.org/10.1101/077651

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Nanopore sequencing in microgravity

Autor: Lindsay F. Rizzardi, Noah Alexander, Kristen K. John, Sarah E. Stahl, Christopher E. Mason, Douglas J. Botkin, Angela M Yu, Ken McGrath, Alexa B. R. McIntyre, Aaron S. Burton, Andrew P. Feinberg, Sarah L. Castro-Wallace, Gail L. Rosen

Publikováno v: NPJ Microgravity

Rapid DNA sequencing and analysis has been a long-sought goal in remote research and point-of-care medicine. In microgravity, DNA sequencing can facilitate novel astrobiological research and close monitoring of crew health, but spaceflight places str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83091f8531182fc7148995f775f72f9
https://pubmed.ncbi.nlm.nih.gov/28725742

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Identification of Coli Surface Antigen 23, a Novel Adhesin of Enterotoxigenic Escherichia coli

Autor: O. Colin Stine, Vsevolod L. Popov, Roberto Vidal, Myron M. Levine, Douglas J. Botkin, Patricio Valenzuela, Fernando Ruiz-Perez, Felipe Del Canto, James P. Nataro, Mihai Pop, Alfredo G. Torres

Publikováno v: INFECTION AND IMMUNITY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea, mainly in developing countries. Although there are 25 different ETEC adhesins described in strains affecting humans, between 15% and 50% of the clinical isolates from differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e5e27d236876f21cd7ba061337bdf6
https://doi.org/10.1128/iai.00263-12

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Nanopore Sequencing in Microgravity

Autor: Angela M Yu, Aaron S. Burton, Sarah L. Castro-Wallace, Noah Alexander, Kristen K. John, Christopher E. Mason, Lindsay F. Rizzardi, Douglas J. Botkin, Gail L. Rosen, Alexa B. R. McIntyre, Andrew P. Feinberg

The ability to perform remote,in situsequencing and diagnostics has been a long-sought goal for point-of-care medicine and portable DNA/RNA measurements. This technological advancement extends to missions beyond Earth as well, both for crew health an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943eecdda0c2688482dd783496d54738
https://doi.org/10.1101/032342

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Identification of Potential Virulence Determinants by Himar1 Transposition of Infectious Borrelia burgdorferi B31

Autor: Philip E. Stewart, Steven J. Norris, Douglas J. Botkin, April N. Abbott, Patricia A. Rosa, Hiroki Kawabata, Haruo Watanabe

Publikováno v: Infection and Immunity. 74:6690-6699

Lyme disease Borrelia organisms are highly invasive spirochetes that alternate between vertebrate and arthropod hosts and that establish chronic infections and elicit inflammatory reactions in mammals. Although progress has been made in the targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89100f017ff91d147224592305c00e16
https://doi.org/10.1128/iai.00993-06

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Characterization of the vls antigenic variation loci of the Lyme disease spirochaetes Borrelia garinii Ip90 and Borrelia afzelii ACAI

Autor: Dachun Wang, Douglas J. Botkin, Steven J. Norris

Publikováno v: Molecular Microbiology. 47:1407-1417

Summary The vls locus of Borrelia burgdorferi B31 consists of 15 silent cassettes and one expression site (vlsE), and the presence of the encoding plasmid lp28-1 correlates with high infectivity. Recombination between the expression cassette and sile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e685ea51ab32265fe3d031c6ef145af6
https://doi.org/10.1046/j.1365-2958.2003.03386.x

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Schistosome Infection Stimulates Host CD4+T Helper Cell and B-Cell Responses against a Novel Egg Antigen, Thioredoxin Peroxidase

Autor: Miguel J. Stadecker, Douglas J. Botkin, Hiroko Asahi, David L. Williams

Publikováno v: Infection and Immunity. 69:1134-1141

Egg granuloma formation during schistosome infections is mediated by CD4+T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown. Here we show that schistosome thioredoxin peroxidase (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef5bc8d0254a980af9f7274bcdafe95
https://doi.org/10.1128/iai.69.2.1134-1141.2001

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Development of a Multiplex PCR Assay for Detection of Shiga Toxin-Producing Escherichia coli, Enterohemorrhagic E. coli, and Enteropathogenic E. coli Strains

Autor: Douglas J. Botkin, Marta Rivas, Michael Soler, Alfredo G. Torres, Lucía Galli, Vinoth Sankarapani

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scopus-Elsevier
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Frontiers in Cellular and Infection Microbiology

Escherichia coli O157:H7 and other pathogenic E.coli strains are enteric pathogens associated with food safety threats and which remaina significant cause of morbidity and mortality worldwide. In the current study, we investigated whether enterohemor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea87b44c9224ffa7335dfd01d36da276
https://www.frontiersin.org/articles/10.3389/fcimb.2012.00008/full

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