Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Douglas I. Walker"'
Autor:
Shiwen Li, Yuyuan Lin, Dean Jones, Douglas I. Walker, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Adrienne M. Keener, Jeff Bronstein, Beate Ritz, Kimberly C. Paul
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in
Externí odkaz:
https://doaj.org/article/1e33afffaa0c46709b2ca76fde368759
Autor:
Kimberly C. Paul, Keren Zhang, Douglas I. Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M. Keener, Jeff Bronstein, Dean P. Jones, Beate Ritz
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-16 (2023)
Abstract Background Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways.
Externí odkaz:
https://doaj.org/article/07fbe5d008ab4d408381b53a0bc4dd5d
Autor:
Melissa A. Furlong, Tuo Liu, Justin M. Snider, Malak M. Tfaily, Christian Itson, Shawn Beitel, Krishna Parsawar, Kristen Keck, James Galligan, Douglas I. Walker, John J. Gulotta, Jefferey L. Burgess
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Firefighters have elevated rates of urinary tract cancers and other adverse health outcomes, which may be attributable to environmental occupational exposures. Untargeted metabolomics was applied to characterize this suite of environmental e
Externí odkaz:
https://doaj.org/article/2fb896ec49dc41b2b3c1c7792671071d
Autor:
Jiawen Carmen Chen, Jesse A. Goodrich, Douglas I. Walker, Jiawen Liao, Elizabeth Costello, Tanya L. Alderete, Damaskini Valvi, Hailey Hampson, Shiwen Li, Brittney O. Baumert, Sarah Rock, Dean P. Jones, Sandrah P. Eckel, Rob McConnell, Frank D. Gilliland, Max T. Aung, David V. Conti, Zhanghua Chen, Lida Chatzi
Publikováno v:
Environment International, Vol 186, Iss , Pp 108601- (2024)
Background: Strong epidemiological evidence shows positive associations between exposure to per- and polyfluoroalkyl substances (PFAS) and adverse cardiometabolic outcomes (e.g., diabetes, hypertension, and dyslipidemia). However, the underlying card
Externí odkaz:
https://doaj.org/article/a0147c01874e4d069f91ff4b60afddfd
Autor:
Hailey E. Hampson, Elizabeth Costello, Douglas I. Walker, Hongxu Wang, Brittney O. Baumert, Damaskini Valvi, Sarah Rock, Dean P. Jones, Michael I. Goran, Frank D. Gilliland, David V. Conti, Tanya L. Alderete, Zhanghua Chen, Leda Chatzi, Jesse A. Goodrich
Publikováno v:
Environment International, Vol 185, Iss , Pp 108454- (2024)
Background: Per- and polyfluoroalkyl substances (PFAS) are pollutants linked to adverse health effects. Diet is an important source of PFAS exposure, yet it is unknown how diet impacts longitudinal PFAS levels. Objective: To determine if dietary inta
Externí odkaz:
https://doaj.org/article/c26e6720f26d44f9b35eb82bfc03f6a9
Autor:
Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose Sánchez, María-Dolores Chirlaque, Marcela Guevara, Maurizio Zibetti, Salvatore Panico, Lefkos Middleton, Verena Katzke, Rudolf Kaaks, Elio Riboli, Giovanna Masala, Sabina Sieri, Raul Zamora-Ros, Pilar Amiano, Mazda Jenab, Susan Peters, Roel Vermeulen
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-8 (2023)
Abstract Introduction Lipopolysaccharide (LPS) is the outer membrane component of Gram-negative bacteria. LPS-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS and has been used as a blood marker for LPS
Externí odkaz:
https://doaj.org/article/2962f05fe2fc4dd3bda9fce1be26ad3b
Autor:
Qi Yan, Di He, Douglas I. Walker, Karan Uppal, Xuexia Wang, Helen T. Orimoloye, Dean P. Jones, Beate R. Ritz, Julia E. Heck
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100123- (2023)
Background: Retinoblastoma is rare but nevertheless the most common pediatric eye cancer that occurs in children under age 5. High-resolution metabolomics (HRM) is a powerful analytical approach to profile metabolic features and pathways or identify
Externí odkaz:
https://doaj.org/article/2a0c8f04ca524389ac0369a6205dc85b
Autor:
In-Hee Lee, Douglas I. Walker, Yufei Lin, Matthew Ryan Smith, Kenneth D. Mandl, Dean P. Jones, Sek Won Kong
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104746- (2023)
Summary: Background: Unravelling the relationships between candidate genes and autism spectrum disorder (ASD) phenotypes remains an outstanding challenge. Endophenotypes, defined as inheritable, measurable quantitative traits, might provide intermedi
Externí odkaz:
https://doaj.org/article/c16ac138231a4ce8923a5cea90341a7e
Autor:
In-Hee Lee, Matthew Ryan Smith, Azam Yazdani, Sumiti Sandhu, Douglas I. Walker, Kenneth D. Mandl, Dean P. Jones, Sek Won Kong
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-14 (2022)
Abstract Background The human exposome is composed of diverse metabolites and small chemical compounds originated from endogenous and exogenous sources, respectively. Genetic and environmental factors influence metabolite levels, while the extent of
Externí odkaz:
https://doaj.org/article/e53b8a652d42422ca398f6c06db3d480
Autor:
Elizabeth Costello, Jesse A. Goodrich, William B. Patterson, Douglas I. Walker, Jiawen (Carmen) Chen, Brittney O. Baumert, Sarah Rock, Frank D. Gilliland, Michael I. Goran, Zhanghua Chen, Tanya L. Alderete, David V. Conti, Lida Chatzi
Publikováno v:
Nutrients, Vol 16, Iss 3, p 429 (2024)
The assessment of “omics” signatures may contribute to personalized medicine and precision nutrition. However, the existing literature is still limited in the homogeneity of participants’ characteristics and in limited assessments of integrated
Externí odkaz:
https://doaj.org/article/b86317bbb1954b4b824a6ed9cff32042