Zobrazeno 1 - 10
of 4 466
pro vyhledávání: '"Douglas I"'
Autor:
Douglas I. Lin, Julia C. F. Quintanilha, Natalie Danziger, Lixin Lang, Diane Levitan, Cynthia Hayne, Matthew C. Hiemenz, David L. Smith, Lee A. Albacker, Jeffrey Leibowitz, Douglas A. Mata, Brennan Decker, Sotirios Lakis, Nimesh R. Patel, Ryon P. Graf, Julia A. Elvin, Jeffrey S. Ross, Varun Pattani, Richard S. P. Huang, Amy K. Wehn
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Microsatellite instability high (MSI-H) and mismatch repair deficient (dMMR) tumor status have been demonstrated to predict patient response to immunotherapies. We developed and validated a next-generation sequencing (NGS)-based companion di
Externí odkaz:
https://doaj.org/article/5b1f54d32e854c9184c1c038f53bf3c6
Autor:
Douglas I. Kelley, Hiromitsu Sato, Michaela Ecker, Chantelle A. Burton, João M. G. Capurucho, John Bates
Publikováno v:
npj Biodiversity, Vol 3, Iss 1, Pp 1-9 (2024)
Abstract The refugia hypothesis, often used to explain Amazonia’s high biodiversity, initially received ample support but has garnered increasing criticism over time. Palynological, phylogenetic, and vegetation model reconstruction studies have bee
Externí odkaz:
https://doaj.org/article/3d2cf8d424714f2c997b243bf12eb6fe
Autor:
Shiwen Li, Yuyuan Lin, Dean Jones, Douglas I. Walker, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Adrienne M. Keener, Jeff Bronstein, Beate Ritz, Kimberly C. Paul
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in
Externí odkaz:
https://doaj.org/article/1e33afffaa0c46709b2ca76fde368759
Autor:
Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijheid, Douglas I Walker, Lisa Zimmermann, Laura M Zoutendijk, Virissa Lenters, Roel Vermeulen
Publikováno v:
JMIR Research Protocols, Vol 13, p e63176 (2024)
BackgroundMicro- and nanoplastics (MNPs) are emerging pollutants of concern with ubiquitous presence in global ecosystems. MNPs pose potential implications for human health; however, the health impacts of MNP exposures are not yet understood. Recent
Externí odkaz:
https://doaj.org/article/39bb2e16daea471ab9383dab15d20b77
Autor:
Suzan van Amerongen, Surya V. Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D. Cherry, Charles Bernick, Yonas E. Geda, Jennifer V. Wethe, Douglas I. Katz, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H. Daneshvar, Elizabeth A. Colasurdo, Jeffrey J. Iliff, Gail Li, Elaine R. Peskind, Martha E. Shenton, Eric M. Reiman, Jeffrey L. Cummings, Robert A. Stern, for the DIAGNOSE CTE Research Project Investigators
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (NBD), a neuropsychiat
Externí odkaz:
https://doaj.org/article/f3d33d808dd64b46a6509a1e9d38248a
Autor:
Michael L. Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O’Connor, John F. Crary, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Bertrand Russell Huber, Thor D. Stein, Ann C. McKee, Jesse Mez
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain donors with autopsy-con
Externí odkaz:
https://doaj.org/article/65a7290a4fbd418a87daa2a3b7d13138
Autor:
Kimberly C. Paul, Keren Zhang, Douglas I. Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M. Keener, Jeff Bronstein, Dean P. Jones, Beate Ritz
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-16 (2023)
Abstract Background Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways.
Externí odkaz:
https://doaj.org/article/07fbe5d008ab4d408381b53a0bc4dd5d
Autor:
Melissa A. Furlong, Tuo Liu, Justin M. Snider, Malak M. Tfaily, Christian Itson, Shawn Beitel, Krishna Parsawar, Kristen Keck, James Galligan, Douglas I. Walker, John J. Gulotta, Jefferey L. Burgess
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Firefighters have elevated rates of urinary tract cancers and other adverse health outcomes, which may be attributable to environmental occupational exposures. Untargeted metabolomics was applied to characterize this suite of environmental e
Externí odkaz:
https://doaj.org/article/2fb896ec49dc41b2b3c1c7792671071d
Autor:
Jiawen Carmen Chen, Jesse A. Goodrich, Douglas I. Walker, Jiawen Liao, Elizabeth Costello, Tanya L. Alderete, Damaskini Valvi, Hailey Hampson, Shiwen Li, Brittney O. Baumert, Sarah Rock, Dean P. Jones, Sandrah P. Eckel, Rob McConnell, Frank D. Gilliland, Max T. Aung, David V. Conti, Zhanghua Chen, Lida Chatzi
Publikováno v:
Environment International, Vol 186, Iss , Pp 108601- (2024)
Background: Strong epidemiological evidence shows positive associations between exposure to per- and polyfluoroalkyl substances (PFAS) and adverse cardiometabolic outcomes (e.g., diabetes, hypertension, and dyslipidemia). However, the underlying card
Externí odkaz:
https://doaj.org/article/a0147c01874e4d069f91ff4b60afddfd
Autor:
Hailey E. Hampson, Elizabeth Costello, Douglas I. Walker, Hongxu Wang, Brittney O. Baumert, Damaskini Valvi, Sarah Rock, Dean P. Jones, Michael I. Goran, Frank D. Gilliland, David V. Conti, Tanya L. Alderete, Zhanghua Chen, Leda Chatzi, Jesse A. Goodrich
Publikováno v:
Environment International, Vol 185, Iss , Pp 108454- (2024)
Background: Per- and polyfluoroalkyl substances (PFAS) are pollutants linked to adverse health effects. Diet is an important source of PFAS exposure, yet it is unknown how diet impacts longitudinal PFAS levels. Objective: To determine if dietary inta
Externí odkaz:
https://doaj.org/article/c26e6720f26d44f9b35eb82bfc03f6a9