Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Douglas Howes"'
Publikováno v:
Toxicology and Applied Pharmacology. 180:74-82
Percutaneous absorption and cutaneous metabolism of 2-ethoxyethanol were assessed in vivo and with an in vitro flow-through diffusion system. Topical application of undiluted (14)C-ethoxyethanol to occluded rat skin in vivo resulted in 25% of the dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275f4be4968a697e526be78c15740fbc
https://doi.org/10.1006/taap.2002.9373
https://doi.org/10.1006/taap.2002.9373
Publikováno v:
Archives of toxicology. 79(3)
The toxicity of glycol ethers is associated with their oxidation to the corresponding aldehyde and alkoxyacetic acid by cytosolic alcohol dehydrogenase (ADH; EC 1.1.1.1.) and aldehyde dehydrogenase (ALDH; 1.2.1.3). Dermal exposure to these compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599b1940db25380a5503f3e7984ad0fd
https://pubmed.ncbi.nlm.nih.gov/15551062
https://pubmed.ncbi.nlm.nih.gov/15551062
Publikováno v:
Archives of toxicology. 78(11)
2-Butoxyethanol (2-BE) is widely used as an industrial solvent, which may result in human dermal exposure within the workplace. This study compares in vivo and in vitro skin absorption of 2-BE using similar application regimes and determines the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4b5627c7f654af2da9497e0cfdce4d
https://pubmed.ncbi.nlm.nih.gov/15455191
https://pubmed.ncbi.nlm.nih.gov/15455191
Publikováno v:
Toxicology and Applied Pharmacology. 45:105-117
When [1-14C]dodecyl sulfonate and [1-14C]hexadecyl sulfonate were administered orally and ip to free-ranging rats and iv to anesthetized rats, the major route of excretion of radioactivity was urinary. Small amounts only of parent surfactant appeared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6b0bd5921ba7f1a0f35f85ff699c64
https://doi.org/10.1016/0041-008x(78)90032-7
https://doi.org/10.1016/0041-008x(78)90032-7
Autor:
S. K. Bains, C. G. Curtis, Gillian M. Powell, Douglas Howes, Anthony H. Olavesen, J. G. Black
Publikováno v:
Xenobiotica. 17:709-723
1. The metabolism of potassium nonan-5-[35S]sulphate, a symmetrical secondary alkylsulphate ester, was investigated in the rat. Oral administration of the radiolabelled ester was followed by the elimination of the majority of radioactivity in the uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21456a08cd31ef9e32cdbc3be8b49ac
https://doi.org/10.3109/00498258709043978
https://doi.org/10.3109/00498258709043978
Publikováno v:
The Biochemical journal. 174(2)
The metabolic fates of the synthetic surfactants, sodium [1-(14)C]undecyltriethoxy sulphate and sodium [1-(14)C]dodecyltriethoxy sulphate were studied in the rat. Both compounds were extensively metabolized regardless of the route of administration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d93dff99a07669d16f0f0096f1e19e
https://pubmed.ncbi.nlm.nih.gov/708392
https://pubmed.ncbi.nlm.nih.gov/708392
Autor:
Kenneth S. Dodgson, J. G. Black, J. L. Maggs, Gillian M. Powell, Douglas Howes, Anthony H. Olavesen
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 12(2)
1. The metabolism of potassium [2-14C]octan-2-sulphate and potassium octan-2-[35S]sulphate was investigated in the rat. Following oral administration, the bulk of the radioactivity was eliminated in the urine within 24 h. 2. Whole-body radioautograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f42c1b26f3eab6fc632188803f439df
https://pubmed.ncbi.nlm.nih.gov/7090421
https://pubmed.ncbi.nlm.nih.gov/7090421
Autor:
Kenneth S. Dodgson, Douglas Howes, Gillian M. Powell, Anthony H. Olavesen, J. G. Black, J. L. Maggs
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 12(10)
1. A comparison was made of the metabolism of potassium D-(+)-octan 2-[35S]sulphate and potassium L-(-)-octan-2-[35S]sulphate in the rat. 2. Following administration of either enantiomer orally or i.v. the major proportion of the radioactivity was ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a78c808d7f913857f4a3f839d32c9b
https://pubmed.ncbi.nlm.nih.gov/7157831
https://pubmed.ncbi.nlm.nih.gov/7157831
Autor:
Peter J. H. Webborn, Gillian M. Powell, J. Gordon Black, C. Gerald Curtis, Douglas Howes, Anthony H. Olavesen
Publikováno v:
Biochemical Society Transactions. 13:891-892
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2b061ffe30c6ddfee2fb47d4c95fbc
https://doi.org/10.1042/bst0130891
https://doi.org/10.1042/bst0130891