Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Douglas H. Sweet"'
Autor:
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8607 (2022)
Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ven
Externí odkaz:
https://doaj.org/article/b8e2cb1b13fb4e639c3779666fe42092
Autor:
Douglas H. Sweet
Publikováno v:
Drug Transporters. :319-332
Autor:
Jae Yoon Jeon, Alice A. Gibson, Alex Sparreboom, Xiyuan Lu, Alessia Lodi, Julie Nguyen, Sharyn D. Baker, Meghan Collins, Douglas H. Sweet, Zahra Talebi, Muhammad Erfan Uddin, Daelynn R. Buelow, Rosa Lapalombella, Shannon R. Sweeney, Moray J. Campbell, Stefano Tiziani, Megan E. Zavorka Thomas, Lindsey T. Brinton
Publikováno v:
Molecular Cancer Therapeutics. 20:2207-2217
Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy associated with frequent relapse and poor overall survival. The tyrosine kinase inhibitor gilteritinib is approved for t
Autor:
Matthew E. Fernandez, Cory B. Fines, Fatemah S. Subul, Sulaiman S. Alhudaithi, Harry D. Bear, Douglas H. Sweet, Sandro R. da Rocha
Publikováno v:
Cancer Research. 83:2328-2328
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks targeted treatment options. While immune check point blockade leads to significant benefits in the treatment of TNBC when in combination with chemotherapy, r
Autor:
Douglas H, Sweet
Publikováno v:
Handbook of experimental pharmacology. 266
The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) represent major control checkpoints protecting the CNS, by exerting selective control over the movement of organic cations and anions into and out of the CNS compartment. In
Autor:
Megan E, Zavorka Thomas, Xiyuan, Lu, Zahra, Talebi, Jae Yoon, Jeon, Daelynn R, Buelow, Alice A, Gibson, Muhammad Erfan, Uddin, Lindsey T, Brinton, Julie, Nguyen, Meghan, Collins, Alessia, Lodi, Shannon R, Sweeney, Moray J, Campbell, Douglas H, Sweet, Alex, Sparreboom, Rosa, Lapalombella, Stefano, Tiziani, Sharyn D, Baker
Publikováno v:
Mol Cancer Ther
Acute myeloid leukemia (AML) with a FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy associated with frequent relapse and poor overall survival. The tyrosine kinase inhibitor gilteritinib is approved for th
Autor:
Douglas H. Sweet
Publikováno v:
Organic Cation Transporters in the Central Nervous System ISBN: 9783030829834
The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) represent major control checkpoints protecting the CNS, by exerting selective control over the movement of organic cations and anions into and out of the CNS compartment. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026711c5d2bac2fa649fddc3da5ba38d
https://doi.org/10.1007/164_2021_463
https://doi.org/10.1007/164_2021_463
Publikováno v:
J Chromatogr B Analyt Technol Biomed Life Sci
A rapid and selective method for the quantitation of neurotransmitters, l-Glutamic acid (GA) and γ–Aminobutyric acid (GABA), was developed and validated using gas chromatography-tandem mass spectrometry (GC–MS/MS). The novel method utilized a ra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4440-4445
Human organic cation transporters (OCTs) represent an understudied neurotransmitter uptake mechanism for which no selective agents have yet been identified. Several neurotransmitters (e.g. serotonin, norepinephrine) are low-affinity substrates for th
Autor:
Shuiying Hu, Giuliano Ciarimboli, Lie Li, Jhm Schellens, Alix F. Leblanc, Alice A. Gibson, Eberhard Schlatter, Jiyoung Kim, D B Finkelstein, Alex Sparreboom, Aksana Vasilyeva, Kristen W. Hong, Navjotsingh Pabla, Douglas H. Sweet, Sharyn D. Baker, Jason A. Sprowl, Laura J. Janke
Publikováno v:
Clinical and Translational Science. 10:412-420
Cisplatin is among the most widely used anticancer drugs and known to cause a dose-limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2-independent pathway of cisplatin