Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Douglas H Thamm"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303470 (2024)
VDX-111 (also identified as AMPI-109) is a vitamin D derivative which has shown anticancer activity. To further assess the function of this compound against multiple cancer types, we examined the efficacy of VDX-111 against a panel of 30 well charact
Externí odkaz:
https://doaj.org/article/61e188de38e44998a8d4a237e82dff33
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200634 (2018)
While extremely rare in humans, hemangiosarcoma (HSA) accounts for nearly 2% of canine neoplasia, and is characterized by both aggressive local growth/invasion and a high rate of metastasis. Both canine and human HSA exhibit sustained aberrant PI3K/A
Externí odkaz:
https://doaj.org/article/837fe27d459f4d3abf91186279e8154b
Autor:
Alejandro Parrales, Peter McDonald, Megan Ottomeyer, Anuradha Roy, Frank J Shoenen, Melinda Broward, Tyce Bruns, Douglas H Thamm, Scott J Weir, Kathleen A Neville, Tomoo Iwakuma, Joy M Fulbright
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194224 (2018)
BACKGROUND:Osteosarcoma is an orphan disease for which little improvement in survival has been made since the late 1980s. New drug discovery for orphan diseases is limited by the cost and time it takes to develop new drugs. Repurposing already approv
Externí odkaz:
https://doaj.org/article/fcfb7274e7014e86bedf45880a5e58f5
Autor:
Hong Zhang, Hongxiu Diao, Lixin Jia, Yujing Yuan, Douglas H Thamm, Huanan Wang, Yipeng Jin, Shimin Pei, Bin Zhou, Fang Yu, Linna Zhao, Nan Cheng, Hongchao Du, Ying Huang, Di Zhang, Degui Lin
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188960 (2017)
A variety of bacteria have been used as agents and vectors for antineoplastic therapy. A series of mechanisms, including native bacterial toxicity, sensitization of the immune system and competition for nutrients, may contribute to antitumor effects.
Externí odkaz:
https://doaj.org/article/37197a619c5841588ae7ead03dd8f7ab
Autor:
Junko Maeda, Coral E Froning, Colleen A Brents, Barbara J Rose, Douglas H Thamm, Takamitsu A Kato
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156689 (2016)
Canine cancer cell lines have progressively been developed, but are still underused resources for radiation biology research. Measurement of the cellular intrinsic radiosensitivity is important because understanding the difference may provide a frame
Externí odkaz:
https://doaj.org/article/9032110d238b4be1b93b4168ecb05b36
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69192 (2013)
There is accumulating evidence that an individual's inability to accurately repair DNA damage in a timely fashion may in part dictate a predisposition to cancer. Dogs spontaneously develop lymphoproliferative diseases such as lymphoma, with the golde
Externí odkaz:
https://doaj.org/article/788704d9276f4be297c269c0e74435e7
Autor:
Junko Maeda, Charles R Yurkon, Hiroshi Fujisawa, Masami Kaneko, Stefan C Genet, Erica J Roybal, Garrett W Rota, Ethan R Saffer, Barbara J Rose, William H Hanneman, Douglas H Thamm, Takamitsu A Kato
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43355 (2012)
Canine osteosarcoma (OSA) is known to present with highly variable and chaotic karyotypes, including hypodiploidy, hyperdiploidy, and increased numbers of metacentric chromosomes. The spectrum of genomic instabilities in canine OSA has significantly
Externí odkaz:
https://doaj.org/article/49d6e295ce5e487cafefba1704e6b458
Publikováno v:
Veterinary and Comparative Oncology. 21:131-137
Autor:
Steven W. Dow, Daniel L. Gustafson, Douglas H. Thamm, Alissa Mathias, Jonathan W. Coy, Jade N. Kurihara, Eric Palmer, Laurel Haines, Sunetra Das, Lyndah Chow, Daniel P. Regan
Supplementary Figure from Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d807ca58bf44c43bbc76a212773e459
https://doi.org/10.1158/1078-0432.22483637
https://doi.org/10.1158/1078-0432.22483637
Autor:
Steven W. Dow, Daniel L. Gustafson, Douglas H. Thamm, Alissa Mathias, Jonathan W. Coy, Jade N. Kurihara, Eric Palmer, Laurel Haines, Sunetra Das, Lyndah Chow, Daniel P. Regan
Purpose:There is increasing recognition that progress in immuno-oncology could be accelerated by evaluating immune-based therapies in dogs with spontaneous cancers. Osteosarcoma (OS) is one tumor for which limited clinical benefit has been observed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17458fd31a5e243205157d79fe3f1565
https://doi.org/10.1158/1078-0432.c.6531188.v1
https://doi.org/10.1158/1078-0432.c.6531188.v1