Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Douglas H Sieglaff"'
Autor:
Aleksandra Cvoro, Aleksandar Bajic, Aijun Zhang, Marisa Simon, Igor Golic, Douglas H Sieglaff, Mirjana Maletic-Savatic, Aleksandra Korac, Paul Webb
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164407 (2016)
Thyroid hormone (TH) receptors (TRs α and β) are homologous ligand-dependent transcription factors (TFs). While the TRs display distinct actions in development, metabolic regulation and other processes, comparisons of TRα and TRβ dependent gene r
Externí odkaz:
https://doaj.org/article/1523de9016e349cf98cdae5c81873882
Autor:
Ji Ho Suh, Arundhati Chattopadhyay, Douglas H Sieglaff, Cheryl Storer Samaniego, Marc B Cox, Paul Webb
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137103 (2015)
The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm. Here, we compared MJC13 and classic AR
Externí odkaz:
https://doaj.org/article/7d9ea420c30e452c91eaf1d8600be977
Autor:
Ji Ho Suh, Douglas H Sieglaff, Aijun Zhang, Xuefeng Xia, Aleksandra Cvoro, Glenn E Winnier, Paul Webb
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70097 (2013)
Sirtuin 1 (SIRT1) NAD(+)-dependent deacetylase regulates energy metabolism by modulating expression of genes involved in gluconeogenesis and other liver fasting responses. While many effects of SIRT1 on gene expression are mediated by deacetylation a
Externí odkaz:
https://doaj.org/article/7a1a5ad93cb54e4888200c611ddff99d
Autor:
Jean Z Lin, Douglas H Sieglaff, Chaoshen Yuan, Jing Su, Anithachristy S Arumanayagam, Sharareh Firouzbakht, Jaime J Cantu Pompa, Frances Denoto Reynolds, Xiabo Zhou, Aleksandra Cvoro, Paul Webb
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52407 (2013)
There are two homologous thyroid hormone (TH) receptors (TRs α and β), which are members of the nuclear hormone receptor (NR) family. While TRs regulate different processes in vivo and other highly related NRs regulate distinct gene sets, initial s
Externí odkaz:
https://doaj.org/article/0807ee0d38164307a5d20fa309c21cb9
Autor:
Marcos, Quintela, Douglas H, Sieglaff, Andrea Salvatore, Gazze, Aijun, Zhang, Deyarina, Gonzalez, Lewis, Francis, Paul, Webb, R Steven, Conlan
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 17
New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::007b9c72de0005bb656f50a8e53c8aab
https://pubmed.ncbi.nlm.nih.gov/30759370
https://pubmed.ncbi.nlm.nih.gov/30759370
Autor:
Paul Webb, Ivan da Rocha Pitta, Angélica Amorim Amato, Flora Aparecida Milton, Anithachristy S. Arumanayagam, Douglas H. Sieglaff, Aleksandra Cvoro, Carly S. Filgueira, Francisco de Assis Rocha Neves, Maria do Carmo Alves de Lima
Publikováno v:
Biochemical and Biophysical Research Communications. 464:718-723
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists that improve insulin resistance but trigger side effects such as weight gain, edema, congestive heart failure and bone loss. GQ-16 is a PPARγ partial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca491f8789beab88c409dd6533b79a5
https://doi.org/10.1016/j.bbrc.2015.07.011
https://doi.org/10.1016/j.bbrc.2015.07.011
Autor:
Douglas H. Sieglaff, Laila Noli, Ji Ho Suh, Dusko Ilic, Celine Filippi, Anil Dhawan, Aleksandra Cvoro, Aijun Zhang, Takao Sakai, Liani Devito, Paul Webb, Keiko Sakai, Flora Aparecida Milton
Publikováno v:
Stem Cells. 33:416-428
Biological processes require close cooperation of multiple transcription factors that integrate different signals. Thyroid hormone receptors (TRs) induce Krüppel-like factor 9 (KLF9) to regulate neurogenesis. Here, we show that triiodothyronine (T3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1714476288c90bc9731671dce6886bc7
https://doi.org/10.1002/stem.1875
https://doi.org/10.1002/stem.1875
Autor:
Rosa Villagomez, Maria Tereza Nunes, Aijun Zhang, Douglas H. Sieglaff, Paul Webb, L. J. Minze, Carly S. Filgueira, Cindy Benod, S. da Silva Teixeira
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aim Thyroid hormones regulate metabolic response. While triiodothyronine (T3) is usually considered to be the active form of thyroid hormone, one form of diiodothyronine (3,5-T2) exerts T3-like effects on energy consumption and lipid metabolism. 3,5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d01abe05637c80a5b7ad6efa6be593
https://pubmed.ncbi.nlm.nih.gov/28029731
https://pubmed.ncbi.nlm.nih.gov/28029731
Publikováno v:
Annu Rev Entomol
Ecdysteroids are multifunctional hormones in male and female arthropods and are stored in oocytes for use during embryogenesis. Ecdysteroid biosynthesis and its hormonal regulation are demonstrated for insect gonads, but not for the gonads of other a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86e8c3538bc918db1ca3e847e8c8f4e
https://doi.org/10.1146/annurev.ento.53.103106.093334
https://doi.org/10.1146/annurev.ento.53.103106.093334
Autor:
Douglas H. Sieglaff, Iris W. Lee, John M. Heraty, Alexander S. Raikhel, Shin-Hong Shiao, James B. Munro, Immo A. Hansen, Josefa Cruz
Publikováno v:
Insect Biochemistry and Molecular Biology. 37:985-997
Forkhead box (Fox) genes encode a family of transcription factors defined by a ‘winged helix’ DNA-binding domain. In this study we aimed to identify Fox factors that are expressed within the fat body of the yellow fever mosquito Aedes aegypti, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a3473f17ba30bc9e07cb7037e64713
https://doi.org/10.1016/j.ibmb.2007.05.008
https://doi.org/10.1016/j.ibmb.2007.05.008