Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Douglas H Kelley"'
Autor:
Aditya Raghunandan, Antonio Ladron-de-Guevara, Jeffrey Tithof, Humberto Mestre, Ting Du, Maiken Nedergaard, John H Thomas, Douglas H Kelley
Publikováno v:
eLife, Vol 10 (2021)
Cerebrospinal fluid (CSF) flowing through periarterial spaces is integral to the brain’s mechanism for clearing metabolic waste products. Experiments that track tracer particles injected into the cisterna magna (CM) of mouse brains have shown evide
Externí odkaz:
https://doaj.org/article/8fd153d1e9ff4311926500ce88cf1f95
Publikováno v:
New Journal of Physics, Vol 15, Iss 2, p 025036 (2013)
Although understanding the collective migration of cells, such as that seen in epithelial sheets, is essential for understanding diseases such as metastatic cancer, this motion is not yet as well characterized as individual cell migration. Here we ad
Externí odkaz:
https://doaj.org/article/2be7eeef122e48b791dc5e3083e98e24
Autor:
Jeffrey Tithof, Kimberly A.S. Boster, Peter A.R. Bork, Maiken Nedergaard, John H. Thomas, Douglas H. Kelley
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104258- (2022)
Summary: Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain delivers nutrients, clears metabolic waste, and causes edema formation. Brain-wide imaging cannot resolve PVSs, and high-resolution methods cannot access deep
Externí odkaz:
https://doaj.org/article/75d4dcf08bd64942a3620d965bf07b9b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer’s disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow
Externí odkaz:
https://doaj.org/article/0313ce98c27640ceb8a913cd2daae2e4
Autor:
Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match
Externí odkaz:
https://doaj.org/article/31e452ba634047b983250f695ea05139
Autor:
Douglas H. Kelley, John H. Thomas
Publikováno v:
Annual Review of Fluid Mechanics. 55:237-264
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and through the brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, and metabolic wastes. Passing t
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/46ae0c6a111e4c73bdbe5f36cdcf431b
Publikováno v:
JOM. 74:1908-1915
Autor:
Kimberly A. S. Boster, Shengze Cai, Antonio Ladrón-de-Guevara, Jiatong Sun, Xiaoning Zheng, Ting Du, John H. Thomas, Maiken Nedergaard, George Em Karniadakis, Douglas H. Kelley
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Quantifying the flow of cerebrospinal fluid (CSF) is crucial for understanding brain waste clearance and nutrient delivery, as well as edema in pathological conditions such as stroke. However, existing in vivo techniques are limited to sparse velocit
Autor:
Nikola Raicevic, Jarod M. Forer, Antonio Ladron-de-Guevara, Ting Du, Maiken Nedergaard, Douglas H. Kelley, Kimberly A. S. Boster
Background: Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of pathogenesis in many diseases. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2c888d1f25f1d47e2e22898ab860f5
https://doi.org/10.21203/rs.3.rs-2587250/v1
https://doi.org/10.21203/rs.3.rs-2587250/v1