Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Douglas G. Widman"'
Autor:
Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S. G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric, Shee-Mei Lok
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the c
Externí odkaz:
https://doaj.org/article/b41f0492a7314c23a5f492f079549fdd
Autor:
Douglas G. Widman, Ellen Young, Boyd L. Yount, Kenneth S. Plante, Emily N. Gallichotte, Derek L. Carbaugh, Kayla M. Peck, Jessica Plante, Jesica Swanstrom, Mark T. Heise, Helen M. Lazear, Ralph S. Baric
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Zika virus (ZIKV), a mosquito-borne flavivirus discovered in 1947, has only recently caused large outbreaks and emerged as a significant human pathogen. In 2015, ZIKV was detected in Brazil, and the resulting epidemic has spread throughout t
Externí odkaz:
https://doaj.org/article/badd76acfe644f0ea9b1b6e9afa5d37b
Autor:
Emily N. Gallichotte, Vineet D. Menachery, Boyd L. Yount, Douglas G. Widman, Kenneth H. Dinnon, Steven Hartman, Aravinda M. de Silva, Ralph S. Baric
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses. In this article, we describe
Externí odkaz:
https://doaj.org/article/2bdffc0943aa48c8baba078388dfcaf8
Autor:
Emily N Gallichotte, Thomas J Baric, Boyd L Yount, Douglas G Widman, Anna Durbin, Steve Whitehead, Ralph S Baric, Aravinda M de Silva
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006934 (2018)
Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. It is estimated that a third of the world's population is at risk for infection, with an estimated 390 million infections annually. Dengue virus se
Externí odkaz:
https://doaj.org/article/10de585de45c4df0a59f2ea02bf756bf
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0200043 (2018)
Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenovirus
Externí odkaz:
https://doaj.org/article/d8d3656e7b3b41a9afd83ead6acbcb8e
Autor:
Ralph S. Baric, Mark T. Heise, H. Driscoll, J. Alexander, D. Bhella, C. Gold, C. D. Syme, Boyd Yount, Bryan A. Ballif, A. M. Schmoker, Jason Botten, Douglas G. Widman, P. Eisenhauer, C. M. Ziegler, E. Hutchinson, I. Manuelyan, D. Terino, J. I. Keller
Flaviviruses are enveloped, positive-strand RNA viruses that cause millions of infections in the human population annually. Although Zika virus (ZIKV) had been detected in humans as early as the 1950s, its reemergence in South America in 2015 resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ada39f6f2454016b94630556443b75
https://doi.org/10.1101/2021.11.24.469793
https://doi.org/10.1101/2021.11.24.469793
Autor:
Justin B Callaway, Scott A Smith, Douglas G Widman, Karen P McKinnon, Frank Scholle, Gregory D Sempowski, Dirk P Dittmer, James E Crowe, Aravinda M de Silva, Jenny P-Y Ting
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136708 (2015)
Dengue virus is a major global health threat and can lead to life-threatening hemorrhagic complications due to immune activation and cytokine production. Cross-reactive antibodies to an earlier dengue virus infection are a recognized risk factor for
Externí odkaz:
https://doaj.org/article/ac6ca7d5c7a14dba88fc25b0cc34eb5a
Autor:
Bhumi Patel, Stephen S. Whitehead, Boyd Yount, Anna P. Durbin, Douglas G. Widman, Aravinda M. de Silva, Usha K. Nivarthi, Jesica Swanstrom, Ralph S. Baric, Matthew J. Delacruz
Publikováno v:
The Journal of Infectious Diseases
National Institutes of Health monovalent dengue vaccines and natural primary dengue virus infections elicit serotype-specific neutralizing antibodies that recognize similar epitopes.
Background Dengue virus is an emerging mosquito-borne flavivir
Background Dengue virus is an emerging mosquito-borne flavivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb8a8b78fe4c5b285788bbc82e33f8d
http://europepmc.org/articles/PMC6581895
http://europepmc.org/articles/PMC6581895
Autor:
Javier Rangel-Moreno, Neha Nandedkar-Kulkarni, Jennifer H. Anolik, Douglas G Widman, Nida Meednu
Publikováno v:
Poster presentations.
Background SLE is an autoimmune disease characterized by activation of the innate and adaptive arms of the immune system. Recently the nuclear export protein exportin-1 (XPO1) has surfaced as an attractive target for the treatment of SLE. Verdinexor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e8e134998a66662a635819686d227b
https://doi.org/10.1136/lupus-2020-eurolupus.183
https://doi.org/10.1136/lupus-2020-eurolupus.183
Autor:
Ralph S. Baric, Jorge E. Osorio, Charalambos D. Partidos, Jesica Swanstrom, Hansi Dean, Douglas G. Widman, Sandra Henein, Boyd Yount, Jessica A. Plante, Emily N. Gallichotte, Aravinda M. de Silva
Publikováno v:
The Journal of Infectious Diseases. 217:1932-1941
BACKGROUND: Dengue virus serotypes 1-4 (DENV-1-4) are the most common vector-borne viral pathogens of humans and the etiological agents of dengue fever and dengue hemorrhagic syndrome. A live-attenuated tetravalent dengue vaccine (TDV) developed by T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a98b8a47b9a7ddd363bd107e407d669
https://doi.org/10.1093/infdis/jiy063
https://doi.org/10.1093/infdis/jiy063