Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Douglas G. Mashek"'
Autor:
Timothy D. Heden, Mallory P. Franklin, Christina Dailey, Mara T. Mashek, Chen Chen, Douglas G. Mashek
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Acyl-CoA thioesterase 1 (ACOT1) catalyzes the hydrolysis of long-chain acyl-CoAs to free fatty acids and CoA and is typically upregulated in obesity. Whether targeting ACOT1 in the setting of high-fat diet–induced (HFD-induced) obesity would be met
Externí odkaz:
https://doaj.org/article/302617a64960419daf03a854101e1d87
Autor:
Charles P. Najt, Santosh Adhikari, Timothy D. Heden, Wenqi Cui, Erica R. Gansemer, Adam J. Rauckhorst, Todd W. Markowski, LeeAnn Higgins, Evan W. Kerr, Matthew D. Boyum, Jonas Alvarez, Sophia Brunko, Dushyant Mehra, Elias M. Puchner, Eric B. Taylor, Douglas G. Mashek
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112435- (2023)
Summary: Organelle interactions play a significant role in compartmentalizing metabolism and signaling. Lipid droplets (LDs) interact with numerous organelles, including mitochondria, which is largely assumed to facilitate lipid transfer and cataboli
Externí odkaz:
https://doaj.org/article/d13a9d2919904d3b8a5be5b15f4656f6
Autor:
Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-10 (2021)
Abstract PHLPP2 is a member of the PHLPP family of phosphatases, known to suppress cell growth by inhibiting proliferation or promoting apoptosis. Oncogenic kinases Akt, S6K, and PKC, and pro-apoptotic kinase Mst1, have been recognized as functional
Externí odkaz:
https://doaj.org/article/8236c7c1a446421294f9a93f782993b1
Autor:
Stacey L. Simon, Jennifer Blankenship, Emily N. C. Manoogian, Satchidananda Panda, Douglas G. Mashek, Lisa S. Chow
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
BackgroundTime restricted eating (TRE), limiting eating to a specific daily window, is a novel dietary intervention, but the mechanisms by which TRE results in weight loss remain unclear. The goal of the current study was to examine changes in eating
Externí odkaz:
https://doaj.org/article/90c175fba728421db42375d7f88aac35
Autor:
Enxiang Zhang, Wenqi Cui, Michael Lopresti, Mara T. Mashek, Charles P. Najt, Hongbo Hu, Douglas G. Mashek
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 338-350 (2020)
Lipid droplets (LDs) are energy-storage organelles that are coated with hundreds of proteins, including members of the perilipin (PLIN) family. PLIN5 is highly expressed in oxidative tissues, including the liver, and is thought to play a key role in
Externí odkaz:
https://doaj.org/article/081328d010024da1b05b34c5048f3ca2
Autor:
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez-Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, Darren N. Saunders, Carina Sihlbom, Andrew J. Hoy, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 178-191 (2020)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational
Externí odkaz:
https://doaj.org/article/5223ec8bf7604ecfadc7de925c7c5dab
Autor:
Douglas G. Mashek
Publikováno v:
Molecular Metabolism, Vol 50, Iss , Pp 101115- (2021)
Background: Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid droplets (LDs) in hepatocytes. While historically considered simply depots for energy storage, LDs are increasingly recognized to impact a wide range of biolog
Externí odkaz:
https://doaj.org/article/1bd58cd2400846b9b8841887ee3d65c9
Autor:
Lisa S. Chow, Darko Bosnakovski, Douglas G. Mashek, Michael Kyba, Rita C.R. Perlingeiro, Alessandro Magli
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102496- (2021)
Satellite cells represent the main myogenic population accounting for skeletal muscle homeostasis and regeneration. While our knowledge of the signaling pathways controlling satellite cell regenerative capability is increasing, the underlying epigene
Externí odkaz:
https://doaj.org/article/ba675eb0761e46d791ae737bbfb58945
Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet
Autor:
Michael W. Lopresti, Wenqi Cui, Breann E. Abernathy, Gavin Fredrickson, Fanta Barrow, Arnav S. Desai, Xavier S. Revelo, Douglas G. Mashek
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100133- (2021)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets in hepatocytes. NAFLD development and progression is associated with an increase in hepatic cholesterol levels and decreased autophagy and lipophagy flux.
Externí odkaz:
https://doaj.org/article/720aeb25ff9d414388b8b72e20b540af
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 1-9 (2017)
Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy. We tested the potential interplay between these metabolic processes
Externí odkaz:
https://doaj.org/article/d0599a83f5664ceca512c530bbe3593d