Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Douglas G. Farmer"'
Autor:
Dongwei Xu, Xiaoye Qu, Tao Yang, Mingwei Sheng, Xiyun Bian, Yongqiang Zhan, Yizhu Tian, Yuanbang Lin, Yuting Jin, Xiao Wang, Michael Ke, Longfeng Jiang, Changyong Li, Qiang Xia, Douglas G. Farmer, Bibo Ke
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 8, Pp 1843-1855 (2024)
Abstract Innate immune activation is critical for initiating hepatic inflammation during nonalcoholic steatohepatitis (NASH) progression. However, the mechanisms by which immunoregulatory molecules recognize lipogenic, fibrotic, and inflammatory sign
Externí odkaz:
https://doaj.org/article/971a8340ac1343509d1ccc9d924aa126
Autor:
Kentaro Kadono, Hidenobu Kojima, Siyuan Yao, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Kenneth J. Dery, Douglas G. Farmer, Fady M. Kaldas, Xiaoling Li, Jerzy W. Kupiec-Weglinski
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-12 (2023)
Abstract Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 regulates the inflamed liver’s canonical pyroptosis cell death pathw
Externí odkaz:
https://doaj.org/article/3a5403bafd664af48bce0be497bd111f
Autor:
Xiaoye Qu, Tao Yang, Xiao Wang, Dongwei Xu, Yeping Yu, Jun Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100879- (2023)
Background & Aims: Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a central player in triggering necroptotic cell death. However, whether macrophage RIPK3 may regulate NOD1-dependent inflammation and calcineurin/transient receptor
Externí odkaz:
https://doaj.org/article/ff345f1706304f7a9531be654746bcd1
Autor:
Hirofumi Hirao, Shoichi Kageyama, Kojiro Nakamura, Kentaro Kadono, Hidenobu Kojima, Yao Siyuan, Douglas G. Farmer, Fady M. Kaldas, Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
T-cell immunoglobulin and mucin (Tim)4 is expressed on APCs, including macrophages, as one of the main amplifiers in the mechanism of liver ischemia-reperfusion injury (IRI) following orthotopic liver transplantation (OLT). Though donor Tim4 selectiv
Externí odkaz:
https://doaj.org/article/aa45fc08703d486b84c22e397c3d50e8
Autor:
Hirofumi Hirao, Hidenobu Kojima, Kenneth J. Dery, Kojiro Nakamura, Kentaro Kadono, Yuan Zhai, Douglas G. Farmer, Fady M. Kaldas, Jerzy W. Kupiec-Weglinski
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Neutrophils, the largest innate immune cell population in humans, are the primary proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic liver transplantation (OLT). Carcinoembryonic antigen–related cell adhesion
Externí odkaz:
https://doaj.org/article/a597728125524ce19b0ebe42471aea24
Autor:
Yongqiang Zhan, Dongwei Xu, Yizhu Tian, Xiaoye Qu, Mingwei Sheng, Yuanbang Lin, Michael Ke, Longfeng Jiang, Qiang Xia, Fady M. Kaldas, Douglas G. Farmer, Bibo Ke
Publikováno v:
JHEP Reports, Vol 4, Iss 9, Pp 100532- (2022)
Background & Aims: The stimulator of interferon genes (STING)/TANK-binding kinase 1 (TBK1) pathway is vital in mediating innate immune and inflammatory responses during oxidative/endoplasmic reticulum (ER) stress. However, it remains unknown whether
Externí odkaz:
https://doaj.org/article/55db7eb1cb564df89ecad978cc09b186
Autor:
Brian D. Friend, Kami Wolfe Schneider, Timothy Garrington, Laurel Truscott, Julian A. Martinez‐Agosto, Robert S. Venick, Eileen Tsai Chambers, Patricia Weng, Douglas G. Farmer, Vivian Y. Chang, Noah Federman
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 7, Pp n/a-n/a (2019)
Abstract Background Polycystic kidney disease (PKD) is an inherited condition characterized by progressive development of end‐stage renal disease, hypertension, hepatic fibrosis, and cysts in the kidney, liver, pancreas, spleen, thyroid, and epidid
Externí odkaz:
https://doaj.org/article/82fa2846375d45a2870b469e46ca9675
Autor:
Robert S. Venick, P. Monteleone, Sue V. McDiarmid, Kimberly L Yan, Antoinette S. Gomes, Jorge Vargas, Douglas G. Farmer
Publikováno v:
Liver Transplantation. 27:1788-1798
Background Post-operative biliary complications have been reported to occur in 10-33% of pediatric liver transplantation (LTx) recipients. (2-10) Percutaneous intervention has become the primary treatment method for these complications; however, effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d225a301a5abd0eb5f2b53459fafcffc
https://doi.org/10.1002/lt.26095
https://doi.org/10.1002/lt.26095
Autor:
Kareem Abu-Elmagd, Douglas G. Farmer
Publikováno v:
American Journal of Transplantation. 22:341-343
The last three decades witnessed continual evolution of the organ allocation strategy. The Organ Procurement and Transplant Network (OPTN) primary goals were to promote patient access to transplantation and improve equity among single and multi-organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc5ca52285dafb64ea010a1d7c33fdf
https://doi.org/10.1111/ajt.16897
https://doi.org/10.1111/ajt.16897
Autor:
Vatche G. Agopian, Hasan Yersiz, Rutger J. Ploeg, Daniela Markovic, Yuri L. Boteon, Sander Florman, Michael P. Harlander-Locke, Ronald W. Busuttil, D Nasralla, Brandy Haydel, Goran B. Klintmalm, Douglas G. Farmer, Neeta Vachharajani, Parissa Tabrizian, Joseph DiNorcia, Victor W. Xia, William C. Chapman, Peter J. Friend, Fady M. Kaldas, Giovanna Saracino
Publikováno v:
Journal of Hepatology. 74:881-892
Background & Aims Early allograft dysfunction (EAD) following liver transplantation (LT) negatively impacts graft and patient outcomes. Previously we reported that the liver graft assessment following transplantation (L-GrAFT7) risk score was superio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913e7db4d46f9f9e119d5ba140519733
https://doi.org/10.1016/j.jhep.2020.09.015
https://doi.org/10.1016/j.jhep.2020.09.015