Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Douglas F. Gibbs"'
Autor:
Hedwig S. Murphy, Douglas F. Gibbs, Kent J. Johnson, Roscoe L. Warner, Thomas P. Shanley, James Varani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:1145-1154
Matrix metalloproteinases (MMPs) have been implicated in the tissue injury seen in neutrophil-dependent models of acute lung injury. However, the role of MMPs in macrophage-dependent models of lung injury is unknown. To address this issue, the macrop
Autor:
Teletha S. Gipson, Nicolas M. Bless, Thomas P. Shanley, Larry D. Crouch, Michael R. Bleavins, Ellen M. Younkin, Vidya Sarma, Douglas F. Gibbs, Wongelawit Tefera, Patrick C. McConnell, William T. Mueller, Kent J. Johnson, Peter A. Ward
Publikováno v:
The Journal of Immunology. 162:3653-3662
Inflammatory lung injury is probably regulated by the balance between proteases and protease inhibitors together with oxidants and antioxidants, and proinflammatory and anti-inflammatory cytokines. Rat tissue inhibitor of metalloprotease-2 (TIMP-2) a
Autor:
Douglas F. Gibbs, Ilana Milo-Goldzweig, Neirmal Singh, Isaac Ginsburg, James Varani, Stanley M. Roberts, Raphael Mechoulam, Sarah Sallon, Aviva Breuer, Milu Sadovnik, Edward Cleator
Publikováno v:
Inflammopharmacology. 7:47-62
Both aqueous and methanolic fractions derived from the Tibetan preparation PADMA-28 (a mixture of 22 plants) used as an anti-atherosclerotic agent, and which is non-cytolytic to a variety of mammalian cells, were found to strongly inhibit (1) the kil
Publikováno v:
Inflammation. 17:227-243
Human neutrophils (PMNs) suspended in Hanks' balanced salt solution (HBSS), which are stimulated either by polycation-opsonized streptococci or by phorbol myristate acetate (PMA), generate nonamplified (CL), luminol-dependent (LDCL), and lucigenin-de
Publikováno v:
Inflammopharmacology. 1:337-351
Human neutrophils (PMNs) stimulated by sub-toxic concentrations of cetyltrimethyl ammonium bromide (CETAB) (37 μmol/L) generated intense luminol-dependent chemiluminescence (LDCL) and moderate non-amplified chemiluminescence (CL), but, paradoxically
Publikováno v:
Pathobiology. 60:93-99
Human epidermal keratinocytes, that have been growth-arrested by removal of epidermal growth factor from the culture medium, are stimulated to proliferate by all-trans retinoic acid (RA). The same treatment inhibits the onset of differentiated featur
Autor:
Anders Vahlquist, John J. Voorhees, E.M.G.J. de Jong, A. Buntinx, Douglas F. Gibbs, B. Friedman, Ethel Tur, Eva Stenström, James Varani, C.O. Bull, Paul L. Stanley, P.C.M. van de Kerkhof, Eva Andersson, Richard H. Guy, Thomas Ruzicka, J.C.M. Scholte, Steiner Stephen A, Hans Törmä, Marie L. Landry, Elka Touitou, Mary Havens, Kenneth M. Tramposch, James A. Mezick, Robert J. Capetola, Gerard J. Gendimenico, M. Ashraf, Pauline M. Schwartz, R. Panchagnula, Petr Arenberger, I.M.M.J. van Vlijmen, Howard I. Maibach, Lajos Kemény, Biren Shah, W. Tanaka, K. Stemmer, W.A. Ritschel, L.M. Milstone, H. Reuveni, Francesca Levi-Schaffer
Publikováno v:
Skin Pharmacology and Physiology. 4:I-VI
Autor:
Brian J. Nickoloff, Tamara Wang, Sem H. Phan, Douglas F. Gibbs, R. S. Mitra, John J. Voorhees, Raj S. Mitra, James Varani, Vishva M. Dixit, Karl J Siebert
Publikováno v:
Journal of Investigative Dermatology. 94(5):717-723
All-trans retinoic acid was examined for effects on human dermal fibroblast proliferation and for effects on fibroblast production and expression of non-collagenous and collagenous components of the extracellular matrix in vitro. Fibroblast prolifera
Publikováno v:
American journal of respiratory cell and molecular biology. 20(6)
Evidence presented in the accompanying article (Gibbs, D. F., T. P. Shanley, R. L. Warner, H. S. Murphy, J. Varani, and K. J. Johnson. 1999. Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury: evidence for alveolar
Autor:
Arul M. Chinnaiyan, James Varani, Michael S. Mulligan, Stephen J. Weiss, Douglas F. Gibbs, Kent J. Johnson, Paul E. Desrochers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(24)
The pulmonary tree is exposed to neutrophil-derived serine proteinases and matrix metalloproteinases in inflammatory lung diseases, but the degree to which these enzymes participate in tissue injury remains undefined, as does the therapeutic utility