Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Douglas F, Covey"'
Autor:
Sofia V. Salvatore, Ma. Xenia G. Ilagan, Hongjin Shu, Peter M. Lambert, Ann Benz, Mingxing Qian, Douglas F. Covey, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Neuropsychiatric and neurodegenerative disorders are correlated with cellular stress. Macroautophagy (autophagy) may represent an important protective pathway to maintain cellular homeostasis and functionality, as it targets cytoplasmic comp
Externí odkaz:
https://doaj.org/article/24e2eb9c99354bf5bea267d5965873b1
Autor:
Yukitoshi Izumi, Kazuko A O'Dell, Anil G Cashikar, Steven M Paul, Douglas F Covey, Steven J Mennerick, Charles F Zorumski
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304481 (2024)
Pro-inflammatory changes contribute to multiple neuropsychiatric illnesses. Understanding how these changes are involved in illnesses and identifying strategies to alter inflammatory responses offer paths to potentially novel treatments. We previousl
Externí odkaz:
https://doaj.org/article/0d8f6970cd0642b2afa9379787401a01
Autor:
Yukitoshi Izumi, Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Douglas F Covey, Charles F Zorumski
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 5, Pp 1004-1008 (2023)
Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids have unique properties, including n
Externí odkaz:
https://doaj.org/article/ad9749e901f447faa79b435493d888aa
Autor:
Vibeke Akkerman, Holger A. Scheidt, Peter Reinholdt, Mohammad Bashawat, Maria Szomek, Max Lehmann, Pablo Wessig, Douglas F. Covey, Jacob Kongsted, Peter Müller, Daniel Wüstner
Publikováno v:
BBA Advances, Vol 4, Iss , Pp 100102- (2023)
Natamycin is an antifungal polyene macrolide that is used as a food preservative but also to treat fungal keratitis and other yeast infections. In contrast to other polyene antimycotics, natamycin does not form ion pores in the plasma membrane, but i
Externí odkaz:
https://doaj.org/article/041ec6aab4b0418b99b133f0163d9c86
Autor:
Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights i
Externí odkaz:
https://doaj.org/article/420c08df587c4e738a4706dedda2d860
Autor:
Alice Dupont Juhl, Christian W. Heegaard, Stephan Werner, Gerd Schneider, Kathiresan Krishnan, Douglas F. Covey, Daniel Wüstner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract Mitochondria receive cholesterol from late endosomes and lysosomes (LE/LYSs) or from the plasma membrane for production of oxysterols and steroid hormones. This process depends on the endo-lysosomal sterol transfer protein Niemann Pick C2 (N
Externí odkaz:
https://doaj.org/article/9c8c613b5a6d43229d449d238c083ed0
Autor:
Tamara Timic Stamenic, Francesca M. Manzella, Stefan Maksimovic, Kathiresan Krishnan, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhib
Externí odkaz:
https://doaj.org/article/81ceb9b8553949458fa215c3060c28cb
Autor:
Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely ina
Externí odkaz:
https://doaj.org/article/8debbb05cfa341cf9e039f7b3d81b327
Autor:
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation
Externí odkaz:
https://doaj.org/article/8c787cef8c4b4f1ea698d77807c4d44c
Autor:
Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Publikováno v:
eLife, Vol 11 (2022)
Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively th
Externí odkaz:
https://doaj.org/article/28bf0dd55ae64ba8b05cd03aeee35398