Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Douglas E. Vaughan"'
Autor:
Douglas E. Vaughan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Externí odkaz:
https://doaj.org/article/c52a7dc944644a96a8e5abe4c62a47dc
Autor:
Joshua A. Levine, Carlota Oleaga, Mesut Eren, Ansel P. Amaral, Meng Shang, Elizabeth Lux, Sadiya S. Khan, Sanjiv J. Shah, Yasuhiro Omura, Nathalie Pamir, Joshua Hay, Grant Barish, Toshio Miyata, Hagai Tavori, Sergio Fazio, Douglas E. Vaughan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to several elements of the syndrome, including obesity, hypertension an
Externí odkaz:
https://doaj.org/article/70f544abac804254b08f94ba760c8b5e
Autor:
Robert Ariens, Cecilia Becattini, Markus Bender, Wolfgang Bergmeier, Elisabetta Castoldi, Katrien Devreese, Martin Ellis, David Gailani, Vera Ignjatovic, Paula D. James, Steven Kerrigan, Michele Lambert, Lai Heng Lee, Marcel Levi, Norma Maugeri, Joost Meijers, Juan Melero‐Martin, Alan D. Michelson, Federico Mingozzi, Keith Neeves, Heyu Ni, Anna‐Karin Olsson, Zoltán Prohászka, Marie Ranson, Nicoletta Riva, Yotis Senis, Cornelia H. vanOmmen, Douglas E. Vaughan, John Weisel
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 680-713 (2020)
Abstract The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12‐15, 2019, due to the coronavirus disease 2019 pandemic. The congress convenes annually to discuss clinical and basic topics in h
Externí odkaz:
https://doaj.org/article/27a44bdfe6e44090b3974f0f056fbfe5
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1479-1492 (2018)
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD). Pharmacologic inhibition of PAI
Externí odkaz:
https://doaj.org/article/4d42de89ddbe493787229ea5956e0a91
Autor:
Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibil
Externí odkaz:
https://doaj.org/article/33be840ab0fa4143ad05bd208fc116c2
Autor:
Rahul Rai, Suresh K. Verma, David Kim, Veronica Ramirez, Elizabeth Lux, Chengjin Li, Susmita Sahoo, Lisa D. Wilsbacher, Douglas E. Vaughan, Susan E. Quaggin, Asish K. Ghosh
Publikováno v:
Epigenetics, Vol 12, Iss 11, Pp 1004-1013 (2017)
Hypertension-associated end-organ damage commonly leads to cardiac and renal fibrosis. As no effective anti-fibrotic therapy currently exists, the unchecked progression of fibrogenesis manifests as cardio-renal failure and early death. We have previo
Externí odkaz:
https://doaj.org/article/7dbce0f1f066420eaf5a8232a891d531
Autor:
Rahul Rai, Asish K. Ghosh, Mesut Eren, Alexander R. Mackie, Daniel C. Levine, So-Youn Kim, Jonathan Cedernaes, Veronica Ramirez, Daniele Procissi, Layton H. Smith, Teresa K. Woodruff, Joseph Bass, Douglas E. Vaughan
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1471-1480 (2017)
Summary: Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, the “anti-aging” factors in juvenile circulation re
Externí odkaz:
https://doaj.org/article/e57763e528694b2495fe9be8e1900ad1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1482 (2021)
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in
Externí odkaz:
https://doaj.org/article/ff59cadfee3644879d36b83f98b8fa2c
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 5, Pp 862-871 (2005)
We previously demonstrated that cholesterol deprivation increases endothelial cyclooxygenase-2 (COX-2)-dependent prostacyclin [prostaglandin I2 (PGI2)] production in vitro. Cholesterol directly regulates gene transcription through the sterol response
Externí odkaz:
https://doaj.org/article/0af224de87394709a5e217180438acda
Autor:
Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Douglas E. Vaughan, A. H. Jan Danser, Anton J. M. Roks
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 748 (2016)
Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of card
Externí odkaz:
https://doaj.org/article/c18f7657e9764a9682f7f258224fed46