Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Douglas E. Murphy"'
Autor:
Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng
Publikováno v:
Journal of medicinal chemistry. 61(8)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04cce3bf4928b41080e47e6b530276e
https://pubmed.ncbi.nlm.nih.gov/29526098
https://pubmed.ncbi.nlm.nih.gov/29526098
Autor:
Alan X. Xiang, Tran Chinh Viet, Douglas E. Murphy, Yuefen Zhou, Frank Ruebsam, Sun Hee Kim, Kimkim Dao, Lian-Sheng Li, Zhongxiang Sun, Peter S. Dragovich
Publikováno v:
Tetrahedron: Asymmetry. 19:2796-2803
A 4-step synthesis of an optically active synthetic intermediate [(1 R ,2 S )-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with ( S )-(+)-mandelic acid; compound 12 , >99% de] required for the preparation of a promising H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbc3216e3d6597d5c57d4161151d457
https://doi.org/10.1016/j.tetasy.2008.11.029
https://doi.org/10.1016/j.tetasy.2008.11.029
Autor:
Chun Chow, Daniel Wall, Douglas E. Murphy, Stephen E. Webber, Thomas M. Bertolini, Yuefen Zhou, Zhongxiang Sun, Thomas Hermann, Jamie M. Froelich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3369-3375
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus towards Pseudomonas aeruginosa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d036dfb8db9d0e1b9ba892ff9d73080a
https://doi.org/10.1016/j.bmcl.2008.04.023
https://doi.org/10.1016/j.bmcl.2008.04.023
Autor:
Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3616-3621
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ad75b76b7814c0968de6c9e82a0a6
https://doi.org/10.1016/j.bmcl.2008.04.066
https://doi.org/10.1016/j.bmcl.2008.04.066
Publikováno v:
Synthetic Communications. 38:1909-1916
A novel synthesis of 2-amino-5-methanesulfonylaminobenzenesulfonamide is described. This preparation begins with readily available 4-nitroaniline and proceeds through five steps (isolations) in 41% overall yield. The described chemistry is conducted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe47afce036790b4061bbf15097e6d1
https://doi.org/10.1080/00397910801997512
https://doi.org/10.1080/00397910801997512
Autor:
Yuefen Zhou, Frank Ruebsam, Richard E. Showalter, Thomas Hermann, Lian-Sheng Li, Rupal Patel, Mei Tsan, April Averill, Qiang Zhao, Douglas E. Murphy, Qing Han, Peter S. Dragovich, Charles R. Kissinger, Laurie A. LeBrun, Maria V. Sergeeva, Amit M. Shah, Stephen E. Webber, Tran Chinh Viet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1419-1424
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ba146924b7b853cbebd0093387b7de
https://doi.org/10.1016/j.bmcl.2008.01.005
https://doi.org/10.1016/j.bmcl.2008.01.005
Autor:
Frank Ruebsam, Lian-Sheng Li, Jingjing Zhao, Nebojsa Stankovic, Peter S. Dragovich, Zhongxiang Sun, Thomas M. Bertolini, Yuefen Zhou, Benjamin K. Ayida, Douglas E. Murphy
Publikováno v:
Tetrahedron Letters. 49:811-815
A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4440dfc10a040a3befedc845e0fee425
https://doi.org/10.1016/j.tetlet.2007.11.187
https://doi.org/10.1016/j.tetlet.2007.11.187
Autor:
Yuefen Zhou, Tran Chinh Viet, Thomas M. Bertolini, Douglas E. Murphy, Peter S. Dragovich, Frank Ruebsam, Stephen E. Webber, Zhongxiang Sun, Lian-Sheng Li, Benjamin K. Ayida, Nebojsa Stankovic, Jingjing Zhao
Publikováno v:
Synthesis. 2007:3301-3308
2,6-Disubstituted 5-hydroxy-3(2 H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from α-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de47ae84da131b84c444950c5ef180db
https://doi.org/10.1055/s-2007-990823
https://doi.org/10.1055/s-2007-990823
Autor:
Benjamin K. Ayida, Vlad E. Gregor, Douglas E. Murphy, Klaus B. Simonsen, Dionisios Vourloumis, Geoffrey C. Winters, Sarah Fish, Daniel Wall, Jamie M. Froelich, Zhongxiang Sun, Thomas Hermann, Yuefen Zhou
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4942-4949
We report the structure-guided discovery, synthesis, and initial characterization of 3,5-diamino-piperidinyl triazines (DAPT), a novel translation inhibitor class that targets bacterial rRNA and exhibits broad-spectrum antibacterial activity. DAPT co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2379a6ab4cb67d77a68d82767649df
https://doi.org/10.1128/aac.49.12.4942-4949.2005
https://doi.org/10.1128/aac.49.12.4942-4949.2005
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e26b8f7a7796258392d71a65a8ad93
https://doi.org/10.1021/jm000547o
https://doi.org/10.1021/jm000547o