Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Douglas E. McBean"'
Publikováno v:
Psychopharmacology. 173:287-295
Clinical reports indicate that acute exposure to 3,4-methylenedioxymethamphetamine (MDMA; “Ecstasy”) may induce pathological cerebrovascular responses in human users of the drug, however, the mechanism by which MDMA might effect these pathologica
Publikováno v:
British Journal of Pharmacology. 137:963-970
1 In this study we have examined methylenedioxymethamphetamine (MDMA)-induced toxicity in perinatal rat brain, related this to normal development of serotonin transporter sites (SERT), and determined whether early exposure to MDMA subsequently alters
Autor:
Douglas E. McBean, Victoria Winters, Craig B. Oswald, J. Michael Armstrong, Brian J. Alps, Alasdair D. Wilson
Publikováno v:
British Journal of Pharmacology. 116:3093-3098
1. A new, modified rat two vessel occlusion model (with hypotension) was established and the neuroprotective efficacy of the novel agent lifarizine (RS-87476) was examined. 2. The two vessel occlusion model used in the study was a modification of the
Publikováno v:
Europe PubMed Central
Serotonin-containing nerve fibres innervate cerebral blood vessels, but the source of this innervation and the physiological effects of perivascular serotonin release remain controversial. The purpose of the present study was to examine the effects o
Publikováno v:
Brain Research. 885:295-297
Blood flow and glucose utilization were measured in rat brain after chronic L-NAME treatment followed by acute 7-nitroindazole. Following chronic L-NAME, blood flow was not significantly different from control. Treatment with acute 7-nitroindazole re
Publikováno v:
Brain Research. 555:159-163
Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy- d -[ 14 C]glucose and [ 14 C]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT 1A receptor agonist8-hydroxy-2-(di- n -propylam
Publikováno v:
Psychopharmacology. 105:113-118
The effect of the psychomotor stimulant, 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"), upon integrated cerebral function was measured in rats using the quantitative [14C]deoxyglucose autoradiographic technique. Animals were injected with MDMA
Publikováno v:
Restorative Neurology and Neuroscience. 3:35-40
Blood-brain barrier permeability was measured using [14C]-labelled a-aminoisobutyric acid (AIB) quantitative auto-radiography in rats which had previously received unilateral ibotenate-induced lesions of the nucleus basalis followed by intracortical
Publikováno v:
Neuroscience. 41:703-711
Local cerebral blood flow and local cerebral glucose utilization were measured using quantitative autoradiography in parallel groups of rats (n = 5-7) which 12-15 weeks previously had undergone limited unilateral ibotenate-induced lesion of the nucle
Publikováno v:
Phytotherapy research : PTR. 23(1)
Harpagophytum procumbens (Hp), commonly known as Devil's Claw has been used as a traditional treatment for a variety of illnesses for centuries. Since the early twentieth century, it has become a popular antiinflammatory and analgesic preparation amo