Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Douglas E. Kline"'
Autor:
Tolga Turan, Deepti Kannan, Maulik Patel, J. Matthew Barnes, Sonia G. Tanlimco, Rongze Lu, Kyle Halliwill, Sarah Kongpachith, Douglas E. Kline, Wouter Hendrickx, Alessandra Cesano, Lisa H. Butterfield, Howard L. Kaufman, Thomas J. Hudson, Davide Bedognetti, Francesco Marincola, Josue Samayoa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers. Available data sug
Externí odkaz:
https://doaj.org/article/10180b8808134fbc95b5f5c4b272dbfe
Autor:
Emily Curran, Xiufen Chen, Leticia Corrales, Douglas E. Kline, Thomas W. Dubensky Jr., Priyanka Duttagupta, Marcin Kortylewski, Justin Kline
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2357-2366 (2016)
Type I interferon (IFN), essential for spontaneous T cell priming against solid tumors, is generated through recognition of tumor DNA by STING. Interestingly, we observe that type I IFN is not elicited in animals with disseminated acute myeloid leuke
Externí odkaz:
https://doaj.org/article/324bdbe85b02424f86577727b292b89d
Publikováno v:
OncoImmunology, Vol 6, Iss 4 (2017)
Exposure of cancer cells to particular chemotherapeutic agents or γ-irradiation induces a form of cell death that stimulates an immune response in mice. This “immunogenic cell death” requires calreticulin (CRT) translocation to the plasma membra
Externí odkaz:
https://doaj.org/article/f47e148b08a84fc89451da5678b85dfc
Autor:
Xiufen Chen, Daniel S. Leventhal, Justin Kline, Douglas E. Kline, Annie R Albright, Peter A. Savage, Brendan W. MacNabb
Publikováno v:
J Immunol
Deletion of CD8+ T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. Although DC-mediated peripheral deletion of autoreactive CD8+ T cells has been demonstrated using T cells reactive to model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245d3f5ce555257150acbd7ca65c236
https://doi.org/10.4049/jimmunol.1801621
https://doi.org/10.4049/jimmunol.1801621
Autor:
Douglas E. Kline, Robbert M. Spaapen, Sravya Tumuluru, Xiufen Chen, Darshan N. Kasal, James Godfrey, Brendan W. MacNabb, Jovian Yu, Marlieke L.M. Jongsma, Justin Kline
Publikováno v:
SSRN Electronic Journal.
Antigen cross-presentation, wherein dendritic cells (DC) present exogenous antigen on MHC-I molecules, is considered the primary mechanism by which DCs initiate tumor-specific CD8+ T cell responses. Here, we demonstrate that MHC-dressing, an antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7578f9dff5b065539466ca7329a9f2f3
https://doi.org/10.2139/ssrn.3838998
https://doi.org/10.2139/ssrn.3838998
Autor:
Douglas E. Kline, Leticia Corrales, Thomas W. Dubensky, Justin Kline, Marcin Kortylewski, Priyanka Duttagupta, Emily Curran, Xiufen Chen
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2357-2366 (2016)
SummaryType I interferon (IFN), essential for spontaneous T cell priming against solid tumors, is generated through recognition of tumor DNA by STING. Interestingly, we observe that type I IFN is not elicited in animals with disseminated acute myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05df4ee1471a0733cdd71556b51ed91
http://www.sciencedirect.com/science/article/pii/S2211124716305915
http://www.sciencedirect.com/science/article/pii/S2211124716305915
Autor:
Haochu Huang, Douglas E. Kline, Peter A. Savage, Julian M. Berger, Nicholas D. Socci, Donald J. Vander Griend, Sven Malchow, Saki Nishi, Daniel S. Leventhal, Victoria Lee, Dana C. Gilmore, Justin Kline
Publikováno v:
Immunity. 44:847-859
Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+) regulatory T (Treg) cell biology, including development and function, the cell types that present antigen to Treg cells in vivo remain largely undef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fa976a17f6da7f27400b8b0c89b9ea
https://doi.org/10.1016/j.immuni.2016.01.025
https://doi.org/10.1016/j.immuni.2016.01.025
Autor:
Douglas E. Kline, Brendan W. MacNabb, Justin Kline, Wen-Ching Chan, Xiufen Chen, Dominick Fosco
APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α+ and CD103+ dendritic cells (DCs), in particular, are required for the spontaneous initiation of CD8+ T cell priming against solid tumors. In contrast, little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5073c22657cac15e7ddf05e94b0f40
https://europepmc.org/articles/PMC6444187/
https://europepmc.org/articles/PMC6444187/
Autor:
J. Matthew Barnes, Davide Bedognetti, Lisa H. Butterfield, Rongze Lu, Wouter Hendrickx, Douglas E. Kline, Francesco M. Marincola, Howard L. Kaufman, Kyle Halliwill, Tolga Turan, Maulik Patel, Josue Samayoa, Sarah Kongpachith, Alessandra Cesano, Deepti Kannan, Thomas J. Hudson, Sonia G. Tanlimco
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-10 (2018)
Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers. Available data suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd03aa10e66ff0398674803204bf1f8
https://doi.org/10.1186/s40425-018-0355-5
https://doi.org/10.1186/s40425-018-0355-5
Autor:
Dominick Fosco, Justin Kline, Peter A. Savage, Douglas E. Kline, Saki Nishi, Xiufen Chen, Liping Meng
Publikováno v:
European Journal of Immunology. 44:2603-2616
Treg cells and the programed death-1/programed death ligand-1 (PD-1/PD-L1) pathway are both critical for maintaining peripheral tolerance to self-Ags. A significant subset of Treg cells constitutively expresses PD-1, which prompted an investigation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e4ba6d5a0495068928686115545a20
https://doi.org/10.1002/eji.201344423
https://doi.org/10.1002/eji.201344423