Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Douglas E. Burger"'
Autor:
Douglas E Burger, Limei Wang, Liqin Ban, Yoshiaki Okubo, Willem M Kühtreiber, Ashley K Leichliter, Denise L Faustman
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22430 (2011)
Progress in clinical trials in infectious disease, autoimmunity, and cancer is stymied by a dearth of successful whole cell biomarkers for peripheral blood lymphocytes (PBLs). Successful biomarkers could help to track drug effects at early time point
Externí odkaz:
https://doaj.org/article/f10dd80b6d5f44d5974051264ab06882
Autor:
Denise L. Faustman, P. Reinhold, E. Hsu, Willem M. Kühtreiber, Douglas E. Burger, Hui Zheng, M. Zhao, S. L. L. Washer
Publikováno v:
Diabetic Medicine. 32:1346-1353
To determine whether the low C-peptide levels ( 50 pmol/l) produced by the pancreas for decades after onset of Type 1 diabetes have clinical significance.We evaluated fasting C-peptide levels, duration of disease and age of onset in a large cross-sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b20156c82b068a0c48808d431ddc5
https://doi.org/10.1111/dme.12850
https://doi.org/10.1111/dme.12850
Autor:
Elise Hsu, Denise L. Faustman, Danielle Baum, Peter E Reinhold, Sarah Warden, Limei Wang, Menghan Zhao, Georges Tahhan, Douglas E. Burger, Melanie Heinrich
Publikováno v:
Antibodies, Vol 4, Iss 1, Pp 34-47 (2015)
Antibodies
Volume 4
Issue 1
Pages 34-47
Antibodies
Volume 4
Issue 1
Pages 34-47
Several autoimmune diseases are marked by a deficiency of soluble tumor necrosis factor (TNF). The TNF deficiency is caused in at least one autoimmune disease, multiple sclerosis, by an overabundance of TNF receptor 1 (TNFR1). Excess TNFR1 binds and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e542e163801e1aab0156c0e6db49846e
http://www.mdpi.com/2073-4468/4/1/34
http://www.mdpi.com/2073-4468/4/1/34
Autor:
Liqin Ban, Willem M. Kühtreiber, Limei Wang, Douglas E. Burger, Jack Zhang, Denise L. Faustman
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13644-13649
Human autoimmune (AI) diseases are difficult to treat, because immunosuppressive drugs are nonspecific, produce high levels of adverse effects, and are not based on mechanistic understanding of disease. Destroying the rare autoreactive T lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7385ae51544922f1c30d23262e0e68fc
https://doi.org/10.1073/pnas.0803429105
https://doi.org/10.1073/pnas.0803429105
Publikováno v:
Hormone and Metabolic Research. 40:137-146
The spleen of human adults uniquely possesses a reservoir of multilineage adult stem cells that express the developmental transcription factor HOX11. In contrast to hematopoietic stem cells, HOX11+ stem cells hold potentially broader therapeutic appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745551ef58d01a301f93b9d233465c20
https://doi.org/10.1055/s-2007-1022560
https://doi.org/10.1055/s-2007-1022560
Autor:
Elise Hsu, Peter E Reinhold, Douglas E. Burger, Sophie L Leung, Willem M. Kühtreiber, Limei Wang, Hui Zhang, Menghan Zhao, Denise L. Faustman
Publikováno v:
Journal of Diabetes & Metabolism. 5
Tumor necrosis factor (TNF) is a novel immunotherapy for type I diabetes because it selectively kills insulin autoreactive T-cells, which enables recovery of insulin production by pancreatic islet cells. The TNF inducer Bacillus Calmette-Guerin (BCG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2844d05aa7349c14ecc33d944bde5dfc
https://doi.org/10.4172/2155-6156.1000309
https://doi.org/10.4172/2155-6156.1000309
Autor:
Limei Wang, Denise L. Faustman, Liqin Ban, Guotong Man, Joseph Avruch, Douglas E. Burger, Richard Pompei, David A. Schoenfeld, Hui Zheng, David M. Nathan, Yoshiaki Okubo
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41756 (2012)
PLoS ONE
PLoS ONE
Background No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it stimulates innate immunity by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98626890c48979b7fb9a68432b915cfa
https://pubmed.ncbi.nlm.nih.gov/23304723
https://pubmed.ncbi.nlm.nih.gov/23304723
Autor:
Limei Wang, Yoshiaki Okubo, Willem M. Kühtreiber, Ashley K. Leichliter, Liqin Ban, Douglas E. Burger, Denise L. Faustman
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22430 (2011)
PLoS ONE
PLoS ONE
Background Progress in clinical trials in infectious disease, autoimmunity, and cancer is stymied by a dearth of successful whole cell biomarkers for peripheral blood lymphocytes (PBLs). Successful biomarkers could help to track drug effects at early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c35b2c9e7a800a2344db0a6631be6f5
http://europepmc.org/articles/PMC3142167?pdf=render
http://europepmc.org/articles/PMC3142167?pdf=render
Developmental biology has long been ignored in the etiology and diverse manifestations of autoimmune diseases. Yet a role for development is suggested by intriguing overlaps in particular organs targeted in autoimmune diseases, in this case type 1 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4752967fc7bcff556666e52d3e210300
https://europepmc.org/articles/PMC4115331/
https://europepmc.org/articles/PMC4115331/
Publikováno v:
Archives of Environmental Health: An International Journal. 45:335-341
A k-x-ray fluorescence (K-XRF) instrument that can measure in vivo bone lead at low levels was used on a population of 34 adults with no known history of excessive lead exposure. A questionnaire that gathered information relevant to occupational and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7864e7517b6d70e20af53aeb2ccc9585
https://doi.org/10.1080/00039896.1990.10118752
https://doi.org/10.1080/00039896.1990.10118752