Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Douglas E. Biancur"'
Autor:
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose con
Externí odkaz:
https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374
Autor:
Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowski, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis. However, the specific c
Externí odkaz:
https://doaj.org/article/2e99d5fbb5aa4a168f142dcbd5bdfea4
Autor:
Joseph D. Mancias, Andrew J. Aguirre, Jonathan A. Nowak, Yatrik M. Shah, Annan Yang, Wesley Huang, Connor J. Hennessey, Kristen E. Lowder, Nupur K. Das, Brandon Chen, Douglas E. Biancur, Kristen M. John, Miljan Kuljanin, Clara Poupault, Callum Malcolm, Ajami Gikandi, Huan Zhang, Kevin S. Kapner, Maria Quiles del Rey, Naiara Santana-Codina
Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression are unclear. Ferritin, the cellular iron storage complex, is targeted for lysosomal degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df60a8a731a7a45f287ddffb872e481
https://doi.org/10.1158/2159-8290.c.6549554
https://doi.org/10.1158/2159-8290.c.6549554
Autor:
Joseph D. Mancias, Andrew J. Aguirre, Jonathan A. Nowak, Yatrik M. Shah, Annan Yang, Wesley Huang, Connor J. Hennessey, Kristen E. Lowder, Nupur K. Das, Brandon Chen, Douglas E. Biancur, Kristen M. John, Miljan Kuljanin, Clara Poupault, Callum Malcolm, Ajami Gikandi, Huan Zhang, Kevin S. Kapner, Maria Quiles del Rey, Naiara Santana-Codina
Supplementary Figure from NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec2530edbf335fd3e84ebbf22ef7855
https://doi.org/10.1158/2159-8290.22541114.v1
https://doi.org/10.1158/2159-8290.22541114.v1
Autor:
Joseph D. Mancias, Andrew J. Aguirre, Jonathan A. Nowak, Yatrik M. Shah, Annan Yang, Wesley Huang, Connor J. Hennessey, Kristen E. Lowder, Nupur K. Das, Brandon Chen, Douglas E. Biancur, Kristen M. John, Miljan Kuljanin, Clara Poupault, Callum Malcolm, Ajami Gikandi, Huan Zhang, Kevin S. Kapner, Maria Quiles del Rey, Naiara Santana-Codina
Supplementary Table from NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f80b119732fbb4d264cc3dde406760
https://doi.org/10.1158/2159-8290.22541111
https://doi.org/10.1158/2159-8290.22541111
Autor:
Joseph D. Mancias, Andrew J. Aguirre, Jonathan A. Nowak, Yatrik M. Shah, Annan Yang, Wesley Huang, Connor J. Hennessey, Kristen E. Lowder, Nupur K. Das, Brandon Chen, Douglas E. Biancur, Kristen M. John, Miljan Kuljanin, Clara Poupault, Callum Malcolm, Ajami Gikandi, Huan Zhang, Kevin S. Kapner, Maria Quiles del Rey, Naiara Santana-Codina
Supplementary Data from NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d1264c8cea10a6bc8d55540c0b04d9
https://doi.org/10.1158/2159-8290.22541117.v1
https://doi.org/10.1158/2159-8290.22541117.v1
Autor:
Naiara Santana-Codina, Maria Quiles del Rey, Kevin S. Kapner, Huan Zhang, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen M. John, Douglas E. Biancur, Brandon Chen, Nupur K. Das, Kristen E. Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias
Publikováno v:
Cancer Discov
Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression are unclear. Ferritin, the cellular iron storage complex, is targeted for lysosomal degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ce98a0377ced9d738825fd338101f7
https://europepmc.org/articles/PMC9437572/
https://europepmc.org/articles/PMC9437572/
Autor:
Piotr Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, Kody P. Mansfield, Brandon Hsieh, Douglas E. Biancur, Samantha B. Larsen, Michael Cammer, Dongqing Li, Ning Xu Landén, Cynthia Loomis, Adriana Heguy, Anastasia N. Tikhonova, Aristotelis Tsirigos, Shruti Naik
Publikováno v:
Science
INTRODUCTION: Injury compromises our epithelial barriers, leaving them vulnerable to external threats. Organismal survival thus impinges on rapid barrier re-establishment after damage. Immunocompromised individuals and immunodeficient animals have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f344f702ca1338afc3a8e28e9e45b3
https://europepmc.org/articles/PMC9753231/
https://europepmc.org/articles/PMC9753231/
Autor:
Alexandre Detappe, Robert Langer, Romain Guieze, Pascal Drané, Douglas E. Biancur, Sijumon Kunjachan, G. Mike Makrigiorgos, Vincent Motto-Ros, Lucie Sancey, Olivier Tillement, Ross Berbeco
Publikováno v:
Journal of Controlled Release. 329:1283-1285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66b7175fb9bcdbf95b473ba230ddf18
https://doi.org/10.1016/j.jconrel.2020.08.029
https://doi.org/10.1016/j.jconrel.2020.08.029
Autor:
Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper
Publikováno v:
eLife, Vol 4 (2015)
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes ar
Externí odkaz:
https://doaj.org/article/5af6e8d673d04762ad593f5eaec09092