Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Douglas E Brough"'
Autor:
Rubén Osuna-Gómez, Ivan Castellví, Maria Mulet, Mª Àngels Ortiz, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Silvia Vidal
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10567 (2023)
This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. By comparing the cytokine levels in healthy donors (HD) and SSc patients using ELISAs, we found
Externí odkaz:
https://doaj.org/article/774cabab10f841669e7c2c15f77c5d2c
Autor:
Maxwell Y. Lee, Simon Metenou, Douglas E. Brough, Helen Sabzevari, Ke Bai, Caroline Jochems, Jeffrey Schlom, Clint T. Allen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Activation of antigen-specific T-lymphocyte responses may be needed to cure disorders caused by chronic infection with low-risk human papillomavirus (lrHPV). Safe and effective adjuvant therapies for such disorders are needed. The safety and
Externí odkaz:
https://doaj.org/article/4ee4cb16ac8a46e2a8da230bdd87a086
Autor:
Madeleine St. Peter, Douglas E. Brough, Anna Lawrence, Jennifer Nelson-Brantley, Peixin Huang, Jennifer Harre, Athanasia Warnecke, Hinrich Staecker
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Background: Survival and integrity of the spiral ganglion is vital for hearing in background noise and for optimal functioning of cochlear implants. Numerous studies have demonstrated that supplementation of supraphysiologic levels of the neurotrophi
Externí odkaz:
https://doaj.org/article/3f13772c2bad4be89145acbe1a2b4c02
Autor:
Samuel T. Pellom, Claire Smalley Rumfield, Y. Maurice Morillon II, Nicholas Roller, Lisa K. Poppe, Douglas E. Brough, Helen Sabzevari, Jeffrey Schlom, Caroline Jochems
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
There are approximately 44,000 cases of human papillomavirus–associated (HPV-associated) cancer each year in the United States, most commonly caused by HPV types 16 and 18. Prophylactic vaccines successfully prevent healthy people from acquiring HP
Externí odkaz:
https://doaj.org/article/23d2fa7a4ec74f2a9d94ecf908385524
Autor:
Rubén Osuna‐Gómez, Silvia Barril, Maria Mulet, Carlos Zamora Atenza, Paloma Millan‐Billi, Ana Pardessus, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Diego Castillo, Silvia Vidal
Publikováno v:
Immunology. 168:610-621
Pulmonary fibrosis involves various types of immune cells and soluble mediators, including TGF-β and IL-35, a recently identified heterodimeric cytokine that belongs to the IL-12 cytokine family. However, the effect of regulatory IL-35 may play an i
Autor:
John G. Neilan, Christopher Schutta, José Barrera, Melia Pisano, Laszlo Zsak, Ethan Hartwig, Max V. Rasmussen, Barbara J. Kamicker, Damodar Ettyreddy, Douglas E. Brough, Bryan T. Butman, David A. Brake
Publikováno v:
BMC Veterinary Research, Vol 14, Iss 1, Pp 1-9 (2018)
Abstract Background A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized w
Externí odkaz:
https://doaj.org/article/d44e40a861c547708a6f63307b3c82ea
Autor:
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 20-31 (2017)
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has p
Externí odkaz:
https://doaj.org/article/87ae21e3c62d43e7adcd0df59c011f76
Autor:
Vidal, Rubén Osuna-Gómez, Ivan Castellví, Maria Mulet, Mª Àngels Ortiz, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Silvia
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10567
This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. By comparing the cytokine levels in healthy donors (HD) and SSc patients using ELISAs, we found
Autor:
Keith Limbach, Maureen Stefaniak, Ping Chen, Noelle B. Patterson, Grant Liao, Shaojie Weng, Svetlana Krepkiy, Greg Ekberg, Holly Torano, Damodar Ettyreddy, Kalpana Gowda, Sharvari Sonawane, Arnel Belmonte, Esteban Abot, Martha Sedegah, Michael R. Hollingdale, Ann Moormann, John Vulule, Eileen Villasante, Thomas L. Richie, Douglas E. Brough, Joseph T. Bruder
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background A DNA-human Ad5 (HuAd5) prime-boost malaria vaccine has been shown to protect volunteers against a controlled human malaria infection. The potency of this vaccine, however, appeared to be affected by the presence of pre-existing i
Externí odkaz:
https://doaj.org/article/16f9c4217eb9443ea1a9be99f6391e9f
Autor:
Ahmed O. Hassan, Igor P. Dmitriev, Elena A. Kashentseva, Haiyan Zhao, Douglas E. Brough, Daved H. Fremont, David T. Curiel, Michael S. Diamond
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2634-2646.e4 (2019)
Summary: The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) protei
Externí odkaz:
https://doaj.org/article/353b0f2914c9464db388d5b645a448dd