Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Douglas E, Kamen"'
Autor:
Preeti G, Desai, Patrick, Garidel, Francisca O, Gbormittah, Douglas E, Kamen, Brittney J, Mills, Chakravarthy N, Narasimhan, Shubhadra, Singh, Elaine S E, Stokes, Erika R, Walsh
Publikováno v:
Journal of Pharmaceutical Sciences. 112:359-369
Developing high-dose biologic drugs for subcutaneous injection often requires high-concentration formulations and optimizing viscosity, solubility, and stability while overcoming analytical, manufacturing, and administration challenges. To understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2723942fc9795493b62e3ab0c13db841
https://doi.org/10.1016/j.xphs.2022.11.020
https://doi.org/10.1016/j.xphs.2022.11.020
Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody
Autor:
Xiaobin Xu, Jessica Ann O'Callaghan, Zachary Guarnero, Haibo Qiu, Ning Li, Terra Potocky, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Teng-Chieh Yang
Publikováno v:
Biophysical Journal. 121:1081-1093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f1f7befc26b8b7a2252b3ae6212e7d
https://doi.org/10.1016/j.bpj.2022.02.002
https://doi.org/10.1016/j.bpj.2022.02.002
Autor:
Xiaobin, Xu, Jessica Ann, O'Callaghan, Zachary, Guarnero, Haibo, Qiu, Ning, Li, Terra, Potocky, Douglas E, Kamen, Kenneth S, Graham, Mohammed, Shameem, Teng-Chieh, Yang
Publikováno v:
Biophysical journal. 121(6)
Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on complementarity-determining regions (CDRs) of a therapeutic monoclonal antibody, its biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1247304182fa96cf0b80cdc6994ab8df
https://pubmed.ncbi.nlm.nih.gov/35122736
https://pubmed.ncbi.nlm.nih.gov/35122736
Autor:
Shubhadra N. Singh, George Crotts, Tanvir Tabish, Qingyan Hu, Brittney J. Mills, Lori S. Burton, Douglas E. Kamen, Hodge Tamara Shafer, Yongmei Wu, Francisca O. Gbormittah, Sonal Saluja, Elaine S.E. Stokes, Kevin Muthurania, Adithi C. Bhargava, Chakravarthy Nachu Narasimhan, Ligi Mathews
Publikováno v:
Journal of pharmaceutical sciences. 111(4)
In-use stability and compatibility studies are often used in biotherapeutic development to assess stability and compatibility of biologic drugs with diluents and/or administration components at relevant conditions for the target route of administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df8538532608b92255c19f48603c61c
https://pubmed.ncbi.nlm.nih.gov/34600941
https://pubmed.ncbi.nlm.nih.gov/34600941
Publikováno v:
Analytical Biochemistry. 637:114472
Polysorbates (PSs) are surfactants commonly added to therapeutic protein drug product formulations to protect proteins from denaturation and aggregation during storage, transportation, and delivery. However, enzymatic hydrolysis of PSs has been recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd68f3936c1c0b875f2af69857ed6d8
https://doi.org/10.1016/j.ab.2021.114472
https://doi.org/10.1016/j.ab.2021.114472
Publikováno v:
Journal of Biomolecular NMR. 40:157-163
G-matrix FT projection NMR spectroscopy was employed for resonance assignment of the 79-residue subunit c of the Escherichia coli F1F0 ATP synthase embedded in micelles formed by lyso palmitoyl phosphatidyl glycerol (LPPG). Five GFT NMR experiments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68b9bc4d110986e53cc038233580a9c
https://doi.org/10.1007/s10858-008-9224-8
https://doi.org/10.1007/s10858-008-9224-8
Publikováno v:
Journal of Virology. 79:6134-6141
Critical events in the life cycle of herpes simplex virus (HSV) are the binding of cytoplasmic capsids to cellular organelles and subsequent envelopment. Work from several laboratories suggests that these events occur as a result of a network of part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c17b8ff81efe9daaa20a829abd4002
https://doi.org/10.1128/jvi.79.10.6134-6141.2005
https://doi.org/10.1128/jvi.79.10.6134-6141.2005
Autor:
Robert W. Woody, Douglas E. Kamen
Publikováno v:
Biochemistry. 41:4713-4723
Pectate lyase C (pelC) is a member of the class of proteins that possess a parallel beta-helix folding motif. A study of the kinetic folding mechanism is presented in this report. Kinetic circular dichroism (CD) and fluorescence have been used to obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c3a64107111bb19cccf5a099ce5c5c
https://doi.org/10.1021/bi0115129
https://doi.org/10.1021/bi0115129
Autor:
Robert W. Woody, Douglas E. Kamen
Publikováno v:
Protein Science. 10:2123-2130
Addition of 8-anilino-1-naphthalenesulfonate (ANS) to acid-denatured pectate lyase C (pelC) leads to a large increase in the fluorescence quantum yield near 480 nm. The conventional interpretation of such an observation is that the ANS is binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02347c900c8904d8c144117f966a04a1
https://doi.org/10.1110/ps.19801
https://doi.org/10.1110/ps.19801
Publikováno v:
Biochemistry. 39:15932-15943
Pectate lyase C (pelC) was the first protein in which the parallel beta-helix structure was recognized. The unique features of parallel beta-helix-containing proteins-a relatively simple topology and unusual interactions among side chains-make pelC a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986a62a48b96920ff83922e59e1fc866
https://doi.org/10.1021/bi001900v
https://doi.org/10.1021/bi001900v