Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Douglas E, Brash"'
Autor:
Douglas E. Brash, Michael M. Seidman
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 5-7 (2020)
Externí odkaz:
https://doaj.org/article/cf26af717d0a471e9d7ba7a0e6f6e6b2
Autor:
Leticia C. P. Gonçalves, Carlos Angelé-Martínez, Sanjay Premi, Meg A. Palmatier, Fernanda Manso Prado, Paolo Di Mascio, Erick L. Bastos, Douglas E. Brash
Publikováno v:
ACS Chemical Biology. 18:484-493
Publikováno v:
Photochemistry and Photobiology. 99:251-276
Autor:
Carlos Angelé-Martínez, Leticia Christina Pires Goncalves, Sanjay Premi, Felipe A. Augusto, Meg A. Palmatier, Saroj K. Amar, Douglas E. Brash
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 357 (2022)
UV-like DNA damage is created in the dark by chemiexcitation, in which UV-activated enzymes generate reactive oxygen and nitrogen species that create a dioxetane on melanin. Thermal cleavage creates an electronically excited triplet-state carbonyl wh
Externí odkaz:
https://doaj.org/article/75e1a84de21d4d788a53be3d93a2d644
Autor:
Elizabeth G. Berry, Joshua Bezecny, Michael Acton, Taylor P. Sulmonetti, David M. Anderson, Haskell W. Beckham, Rebecca A. Durr, Takahiro Chiba, Jennifer Beem, Douglas E. Brash, Rajan Kulkarni, Pamela B. Cassidy, Sancy A. Leachman
Publikováno v:
Cancers, Vol 14, Iss 3, p 542 (2022)
Ultraviolet radiation (UVR) exposure is the most important modifiable risk factor for skin cancer development. Although sunscreen and sun-protective clothing are essential tools to minimize UVR exposure, few studies have compared the two modalities h
Externí odkaz:
https://doaj.org/article/7d9450ddf6de4054a6e553f8a28ee8fd
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Age-related macular degeneration, Stargardt disease, and their Abca4 -/- mouse model are characterized by accelerated accumulation of the pigment lipofuscin, derived from photoreceptor disc turnover in the retinal pigment epithelium (RPE); lipofuscin
Autor:
Edward V. Maytin, Tayyaba Hasan, Douglas E. Brash, Nikoleta Brankov, Kishore R. Rollakanti, Sanjay Anand
Figure S1. UVB-induced squamous cell carcinoma (SCC) of the skin, when treated with 5-FU, shows increased expression of the differentiation marker E-cadherin, relative to vehicle treatment alone. Figure S2. Pretreatment of cutaneous UVB-induced SCC w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4242ee4b6e3ad5e54a24cc248a900d60
https://doi.org/10.1158/1535-7163.22505559
https://doi.org/10.1158/1535-7163.22505559
Autor:
Edward V. Maytin, Tayyaba Hasan, Douglas E. Brash, Nikoleta Brankov, Kishore R. Rollakanti, Sanjay Anand
Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf103ef5debe918f780bc0d54675924d
https://doi.org/10.1158/1535-7163.c.6538116.v1
https://doi.org/10.1158/1535-7163.c.6538116.v1
Autor:
Douglas E Brash
Publikováno v:
eLife, Vol 8 (2019)
Mice get melanoma faster when they have common, inherited variants in a few genes that control cell-wide changes but also respond to the environment.
Externí odkaz:
https://doaj.org/article/ddc8c86074de4eb49b038de49d492f02
Publikováno v:
Photochemistry and photobiology. 98(5)
The dominant DNA damage generated by UV exposure is the cyclobutane pyrimidine dimer (CPD), which alters skin cell physiology and induces cell death and mutation. Genome-wide nucleotide-resolution analysis of CPDs in melanocytes and fibroblasts has i