Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Douglas Decker"'
Autor:
Douglas Decker
Publikováno v:
Education Sciences, Vol 9, Iss 2, p 86 (2019)
Since its inception in medieval Europe, apprenticeships have played a vital role in knowledge transfer from one generation to the next. In a mutually beneficial relationship, the master craftsman passes along years of skill and wisdom to the younger
Externí odkaz:
https://doaj.org/article/e0c3abb057cb4a66bcb1da111d1ffe3b
Autor:
Dione T Kobayashi, Douglas Decker, Phillip Zaworski, Karen Klott, Julie McGonigal, Nabil Ghazal, Laurel Sly, Brett Chung, James Vanderlugt, Karen S Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50763 (2012)
OBJECTIVES: Survival Motor Neuron (SMN) protein levels may become key pharmacodynamic (PD) markers in spinal muscular atrophy (SMA) clinical trials. SMN protein in peripheral blood mononuclear cells (PBMCs) can be quantified for trials using an enzym
Externí odkaz:
https://doaj.org/article/8d4d11805181430faa595da85fcc2c6b
Autor:
Douglas Decker, Kathleen A. Ready, Stephen Buxser, Louise A. Galinet, Steven M. Vroegop, Darryl L. Chapman, Colin J. Dunn, R.J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:647-662
We showed previously that a 5-halo-6-phenyl-pyrimidinone, bropirimine (PNU-54461), inhibited progression of severe experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis. In the work presented here, we examined t
Autor:
Stephen Buxser, Colin J. Dunn, Douglas Decker, Steven M. Vroegop, Louise A. Galinet, Darryl L. Chapman, Kathleen A. Ready, Roger J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:391-409
In murine severe experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis (MS), we tested the efficacy of a 5-halo-6-phenyl pyrimidinone compound, bropirimine (PNU-54461). We observed that the compound
Publikováno v:
Biochemical Pharmacology. 50:1063-1070
N18-RE-105 neuronal hybridoma cells were used in a cell culture system to evaluate the protective effects of a novel 6-chromanol-containing antioxidant, U78517F. First, the incorporation of the compound into the cells was evaluated, using a serum alb
Autor:
Geri A. Sawada, Thomas J. Raub, Craig L. Barsuhn, Norman F.H. Ho, Douglas Decker, Lawrence R. Williams
Publikováno v:
Journal of Drug Targeting. 1:269-286
The novel antioxidants U-78517F and U-74006F, or lazaroids, are highly lipophilic organic molecules with poor brain uptake. To understand this paradoxical behavior better, continuous monolayers of Madin-Darby canine kidney (MDCK) epithelial cells wit
Publikováno v:
Journal of Protein Chemistry. 11:71-82
We compared the receptor binding, antigenicity, biological activation, and cell-mediated proteolytic degradation properties of mouse nerve growth factor (mNGF) and human NGF (hNGF). The affinity of hNGF toward human NGF-receptor is greater than that
Autor:
Steven M. Vroegop, Douglas Decker, Mike Stier, M. H. Shea, Kim A. Curry, Stephen Buxser, Darrell R. Thomsen, Roger A. Poorman, Che-Shen C. Tomich, Irene Abraham, Nicole T. Hatzenbuhler, Jessica Hinzmann, Barry D. Greenberg
Publikováno v:
Journal of Neurochemistry. 56:1012-1018
Human nerve growth factor (NGF) was cloned and engineered for expression in a baculovirus-infected Spodoptera frugiperda (SF-9) insect cell system. Culture supernatants contained 2-3 mg/L of recombinant human NGF. The human NGF produced by this syste
Autor:
R G Ulrich, F. J. Kezdy, Lester A. Dolak, Stephen Buxser, K M Franks, K B Langley, Irene W. Althaus, Fritz Reusser, T. Peterson, Douglas Decker
Publikováno v:
Experientia. 52(4)
Few inhibitors of the RNase H function associated with the HIV-1 reverse transcriptase have been discovered to date. We observed that three novenamines, U-34445, U-35122, and U-35401, are specific inhibitors of the HIV-1 RT RNase H function. All thre
Publikováno v:
Free radical biologymedicine. 21(6)
We examined the efficacy of a group of drugs that stabilize the cell membrane and can potentially prevent cytotoxicity in cultured fetal chick cardiac myocytes exposed to hydrogen peroxide (H2O2). The effects of various membrane-protective agents wer