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Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.

Autor: Alabi A; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Xia XD; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China., Gu HM; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Wang F; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Deng SJ; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Yang N; Experimental Center for Medical Research, Weifang Medical University, Weifang, China., Adijiang A; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Douglas DN; Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Kneteman NM; Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Xue Y; Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China., Chen L; Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China., Qin S; Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China., Wang G; Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China., Zhang DW; The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. dzhang@ualberta.ca.

Publikováno v: Nature communications [Nat Commun] 2021 Mar 25; Vol. 12 (1), pp. 1889. Date of Electronic Publication: 2021 Mar 25.