Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Douglas D. O'Bannon"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:669-681
Sumitriptan (1), a non-selective 5-HT1B/1D agonist is an effective therapeutic agent for the acute treatment of migraine, but it is contraindicated for use in patients with known heart disease. The first Selective Serotonin One F Receptor Agonist (SS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d57ccff4724c3f2e8f4606f90ff872ef
https://doi.org/10.1002/jlcr.959
https://doi.org/10.1002/jlcr.959
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:139-148
Partial ergoline agonists such as (R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenz[cd]-indole-6-carboxamide (LY228729, 1a) mimic a locked conformational analog of serotonin and in fact possess potent in vitro activity as agonists of the 5-HT1A receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea5024bacb609e931be3c33937274b38
https://doi.org/10.1002/jlcr.907
https://doi.org/10.1002/jlcr.907
Autor:
William J. Wheeler, Douglas D. O'Bannon, Tharp-Taylor Roger William, Joseph H. Kennedy, James A. Monn, Fengjiun Kuo, Matthew John Valli
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:605-620
As part of a program aimed at the design of conformationally constrained analogs of glutamic acid, (+)-2-aminobicyclo[3.1.0]hexane-2,6-carboxylic acid (1), identified as a highly potent, selective, group II metabotropic glutamate receptor agonist has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3940b8f9fa1ca51ab0fafef063437400
https://doi.org/10.1002/jlcr.956
https://doi.org/10.1002/jlcr.956
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:85-100
Asymmetric synthesis of AMPA potentiator LY450108-[14C] containing 14C-label attached to the chiral center of the molecule, was accomplished based on Evans' chiral oxazolidinone auxiliary method. Diastereoselective methylation of p-nitrophenylacetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3274416af4455a1e5fe786a2e77eef47
https://doi.org/10.1002/jlcr.899
https://doi.org/10.1002/jlcr.899
Autor:
Michael R. Jirousek, Margaret M. Faul, Steven E. Hall, Douglas D. O'Bannon, John H. McDonald, Leonard L. Winneroski, William Francis Heath, David Andrew Neel, Christopher John Rito, Anita Melikian-Badalian, Matthew Baevsky, Gillig James Ronald, Larwence M Ballas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2093-2096
The synthesis of a novel class of N-N′-macrocyclic bisindolylmaleimides is reported. The key step involves a remarkably efficient intramolecular cyclization reaction. The method was further developed to provide an efficient synthesis of this type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c171761bd59708d8b1d3945c3726f55
https://doi.org/10.1016/0960-894x(95)00350-3
https://doi.org/10.1016/0960-894x(95)00350-3
Autor:
Christopher John Rito, Steven E. Hall, Leonard L. Winneroski, Michael R. Jirousek, Douglas D. O'Bannon, Gillig James Ronald, Margaret M. Faul, John H. McDonald, David Andrew Neel, Larwence M Ballas, William Francis Heath, Anita Melikian-Badalian, Matthew Baevsky
Publikováno v:
ChemInform. 27
The synthesis of a novel class of N-N′-macrocyclic bisindolylmaleimides is reported. The key step involves a remarkably efficient intramolecular cyclization reaction. The method was further developed to provide an efficient synthesis of this type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22427f638b95b2a02119d7b7b344efba
https://doi.org/10.1002/chin.199602196
https://doi.org/10.1002/chin.199602196
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:305-315
The 14C-isotopomer of dapoxetine-[14C] HCl (S (+)-N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl-2-14C]benzenemethanamine hydrochloride, 1a), a potent serotonin re-uptake inhibitor has been prepared by a chiral synthesis, starting with tert.-butyloxyphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db636337cbecb3251224047409dfdc0e
https://doi.org/10.1002/jlcr.2580310406
https://doi.org/10.1002/jlcr.2580310406
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:625-631
Endo-5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8 -azabicyclo-[3.2.1.]-oct-3-yl-7-benzofurancarboxamide-[carbonyl-14C] (Z)-2-butenedioate (zatosetron-[14C] maleate, 1), has been prepared from 5-chloro-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran (5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2c51941d4d24918963bb545d0ccf5d
https://doi.org/10.1002/jlcr.2580290603
https://doi.org/10.1002/jlcr.2580290603
Autor:
Jennifer L. Burkey, Chad E. Hadden, Milton Zmijewski, Douglas D. O'Bannon, Robert J. Barbuch, Palaniappan Kulanthaivel, Ping Yi, Kristina M. Campanale
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(2)
Ruboxistaurin (LY333531), a potent and isoform-selective protein kinase C beta inhibitor, is currently undergoing clinical trials as a therapeutic agent for the treatment of diabetic microvascular complications. The present study describes the dispos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e43374ed41decda652e8e2e9f05f1eb
https://pubmed.ncbi.nlm.nih.gov/16258078
https://pubmed.ncbi.nlm.nih.gov/16258078
Autor:
Charles A. Alt, John W. Babich, Douglas D. O'Bannon, Elden E. Van Meter, Alan J. Fischman, William J. Wheeler, Winston Satterlee, James H. Thrall, Roger L. Robey, E. Livni
Publikováno v:
Nuclear medicine and biology. 21(4)
[11C]Dapoxetine.HCl, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, a potent serotonin re-uptake inhibitor was prepared from its mono-methyl precursor, S-(+)-N-methyl-a-[2-(naphthalenyloxy)ethyl]benzene methanamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789ba941f972f14e4640b33a82dadfd9
https://pubmed.ncbi.nlm.nih.gov/9234326
https://pubmed.ncbi.nlm.nih.gov/9234326