Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Douglas D. Fraser"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
This review describes the impact of COVID-19 on the endocrine system, focusing on cortisol signaling and growth factor-induced endocrine resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation of the adre
Externí odkaz:
https://doaj.org/article/f8db66f20724469eb7424a0e0ab862db
Autor:
Jérôme Bédard-Matteau, Antoine Soulé, Katelyn Yixiu Liu, Lyvia Fourcade, Douglas D. Fraser, Amin Emad, Simon Rousseau
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSevere COVID-19 is associated with neutrophilic inflammation and immunothrombosis. Several members of the IL-17 cytokine family have been associated with neutrophilic inflammation and activation of the endothelium. Therefore, we investigate
Externí odkaz:
https://doaj.org/article/e38b68521d44494dabbf2ed3e13a0aad
Autor:
Maitray A. Patel, Douglas D. Fraser, Mark Daley, Gediminas Cepinskas, Noemi Veraldi, Serge Grazioli
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)
Abstract Background The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patients is im
Externí odkaz:
https://doaj.org/article/28ac426af3e445aba61928b19f8e4d06
Autor:
Sean Leonard, Hailey Guertin, Natalya Odoardi, Michael R. Miller, Maitray A. Patel, Mark Daley, Gediminas Cepinskas, Douglas D. Fraser
Publikováno v:
Journal of Inflammation, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Background Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to identify sepsis early and then quickly intervene to reduce morbidity an
Externí odkaz:
https://doaj.org/article/f872daba81954849b4302323861ace37
Autor:
Logan R. Van Nynatten, Michael R. Miller, Maitray A. Patel, Mark Daley, Guido Filler, Sigrun Badrnya, Markus Miholits, Brian Webb, Christopher W. McIntyre, Douglas D. Fraser
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Acute and chronic kidney disease continues to confer significant morbidity and mortality in the clinical setting. Despite high prevalence of these conditions, few validated biomarkers exist to predict kidney dysfunction. In this study, we ut
Externí odkaz:
https://doaj.org/article/e0badcdf9b7d4abe999b40d86cbb7ae5
Autor:
Tanya Charyk Stewart, Purnima Unni, Holly Renee Hanson, Jason Gilliland, Andrew Clark, Douglas D. Fraser
Publikováno v:
Injury Epidemiology, Vol 10, Iss S1, Pp 1-13 (2023)
Abstract Background The COVID-19 a pandemic changed the world. Public health directives to socially distance with stay-at-home orders altered injury risk factor exposure, resulting injury patterns and conducting injury prevention (IP). The objective
Externí odkaz:
https://doaj.org/article/c18fe987318a4b90ae42d0adcc6cad0a
Autor:
Elina Ghondaghsaz, Amirmohammad Khalaji, Mitra Norouzi, Douglas D. Fraser, Sanam Alilou, Amir Hossein Behnoush
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background With the emergence of coronavirus disease of 2019 (COVID-19), several blood biomarkers have been identified, including the endothelial biomarker syndecan-1, a surface proteoglycan. In the current systematic review and meta-analysi
Externí odkaz:
https://doaj.org/article/a15c497779ec46a49d0a1b26e773e8f7
Autor:
Cristiana Iosef, Michael J. Knauer, Michael Nicholson, Logan R. Van Nynatten, Gediminas Cepinskas, Sorin Draghici, Victor K. M. Han, Douglas D. Fraser
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract Aims Long-COVID occurs after SARS-CoV-2 infection and results in diverse, prolonged symptoms. The present study aimed to unveil potential mechanisms, and to inform prognosis and treatment. Methods Plasma proteome from Long-COVID outpatients
Externí odkaz:
https://doaj.org/article/4157b12e66394d2c894afb0ba8d8d2d2
Autor:
Brent J. Tschirhart, Xiangru Lu, Aristide Laurel Mokale Kognou, Claudio M. Martin, Marat Slessarev, Douglas D. Fraser, Aleksandra Leligdowicz, Bradley Urquhart, Qingping Feng
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Objective: Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and surv
Externí odkaz:
https://doaj.org/article/30877719cec04799b7f2811b1ee78d86
Autor:
Claudio M. Martin, MD, Marat Slessarev, MD, PhD, Eileen Campbell, John Basmaji, MD, Ian Ball, MD, Douglas D. Fraser, MD, PhD, Aleksandra Leligdowicz, MD, PhD, Tina Mele, MD, PhD, Fran Priestap, MSc, Brent J. Tschirhart, MSc, Tracey Bentall, RN, Xiangru Lu, MD, Qingping Feng, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 10, p e0986 (2023)
OBJECTIVES:. To evaluate the study design and feasibility of drug administration and safety in a randomized clinical trial of recombinant human annexin A5 (SY-005), a constitutively expressed protein with anti-inflammatory, antiapoptotic, and anticoa
Externí odkaz:
https://doaj.org/article/f02c7cacc2d4428e8e38bedbb729b0c7