Výsledky vyhledávání - "Douglas Coveney"

BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1 mice

Autor: Blanche Capel, Matthew S. Cook, Iordan S Batchvarov, Joseph H. Nadeau, Douglas Coveney

Publikováno v: Developmental Biology. 328:377-383

A homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1Ter/Ter) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of the gonad in both sexes and all genetic backgrounds tested. The same mutation also leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33594c084ee643666e62481b97b4e645
https://doi.org/10.1016/j.ydbio.2009.01.041

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The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

Autor: Xiaoning Peng, Jian Min Deng, Michael L. Nickerson, Chitralekha Bhattacharya, Blanche Capel, Joseph H. Nadeau, Laura S. Schmidt, Angabin Matin, Edward M. Rubin, Douglas Coveney, Richard R. Behringer, Kirsten K. Youngren, Bruce T. Lamb

Publikováno v: Nature. 435:360-364

The phenotype of Ter testicular germ cell tumour susceptibility gene was first described more than 30 years ago, but it has taken until now for the identity of the gene to be discovered. Ter is a mutation inducing a termination codon on the mouse ver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246b06cc4cc8ffa5e4a93b0a15a0b80e
https://doi.org/10.1038/nature03595

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Effect of an anti-androgen on testicular descent and inguinal closure in a marsupial, the tammar wallaby (Macropus eugenii)

Autor: Marilyn B. Renfree, Douglas Coveney, John M. Hutson, Geoff Shaw

Publikováno v: Reproduction. :865-874

Androgens are essential for testicular descent in eutherian mammals, but little is known about its hormonal control in marsupials. This study reports the effects of daily treatment with the anti-androgen flutamide (10 mg kg(-1)) from day 9 to day 75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3b1e461d5504f452dda35af242e49d
https://doi.org/10.1530/rep.0.1240865

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Estrogen-Induced Gonadal Sex Reversal in the Tammar Wallaby1

Autor: Geoffrey Shaw, Douglas Coveney, Marilyn B. Renfree

Publikováno v: Biology of Reproduction. 65:613-621

Estrogens have a feminizing effect on gonadal differentiation in fish, amphibians, reptiles, and birds. However, the role of estrogen during gonadal differentiation in mammals is less clear. We investigated the effect of estrogen on gonadal different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::263c97595ec33cddeca7517e01745575
https://doi.org/10.1095/biolreprod65.2.613

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A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation

Autor: Douglas Coveney, Jesse Slone, Andrea J. Ross, Blanche Capel

Publikováno v: Gene expression patterns : GEP. 8(7-8)

One of the earliest morphological changes during testicular differentiation is the establishment of an XY specific vasculature. The testis vascular system is derived from mesonephric endothelial cells that migrate into the gonad. In the XX gonad, mes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f10bdc5456f6a36c24de17f23f23b7
https://pubmed.ncbi.nlm.nih.gov/16844427

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Four-dimensional analysis of vascularization during primary development of an organ, the gonad

Autor: Tim Oliver, Douglas Coveney, Jonah Cool, Blanche Capel

Time-lapse microscopy has advanced our understanding of yolk sac and early embryonic vascularization. However, it has been difficult to assess endothelial interactions during epithelial morphogenesis of internal organs. To address this issue we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ec245bf94015a45afab6a66d404db3
https://europepmc.org/articles/PMC2438229/

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The development of the gubernaculum and inguinal closure in the marsupial Macropus eugenii

Autor: Marilyn B. Renfree, Geoffrey Shaw, John M. Hutson, Douglas Coveney

Publikováno v: Journal of anatomy. 201(3)

This study reports the developmental anatomy of testicular descent and inguinal closure of the tammar wallaby (Macropus eugenii) from birth to maturity. In females the ovary migrated caudally between days 10 and 20 after birth. The gubernaculum diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e3a4df62a3756296ec328b73b1b0fe
https://pubmed.ncbi.nlm.nih.gov/12363275

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Erratum to 'A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation' [Gene Expression Patterns 7 (2007) 82–92]

Autor: Jesse Slone, Blanche Capel, Andrea J. Ross, Douglas Coveney

Publikováno v: Gene Expression Patterns. 8:528

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b6e7722382d1b3152bd474be002c801
https://doi.org/10.1016/j.gep.2008.05.005

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The influence of estrogen on the developing male marsupial

Autor: Marilyn B. Renfree, Douglas Coveney, Geoffrey Shaw

Publikováno v: Reproduction, Fertility and Development. 13:231

The genes and hormones involved in gonadal differentiation are highly conserved between eutherians and marsupials, although the timing of the developmental events differs. In marsupials, the testis develops seminiferous cords two days after birth, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd5839b2aea0ce6fa24d0c14a4cdb01
https://doi.org/10.1071/rd00123

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