Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Douglas Caudill"'
Publikováno v:
Toxicological Sciences. 58:23-31
Coumarin, a natural product and fragrance ingredient, is a well recognized rat liver toxicant, and dietary administration at toxic dosages increased the incidence of rat cholangiocarcinomas and parenchymal liver-cell tumors in a chronic bioassay. Hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd4ebe23a8787e72361e19ffa3742dd
https://doi.org/10.1093/toxsci/58.1.23
https://doi.org/10.1093/toxsci/58.1.23
Publikováno v:
Toxicology and Applied Pharmacology. 151:45-56
Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the mouse lung was identified as a major target organ in a chronic bioassay, with an oral gavage dosage of 200 mg/kg coumarin increasing the incidence of alveolar/b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ca934a4b4b8188ab4350af5df72812
https://doi.org/10.1006/taap.1998.8442
https://doi.org/10.1006/taap.1998.8442
Publikováno v:
Toxicology and Applied Pharmacology. 149:32-40
Mouse urinary protein (MUP) and alpha 2u-globulin are structurally homologous proteins that belong to a superfamily of ligand-binding proteins and represent the major urinary proteins excreted by adult male mice and rats, respectively. Although a var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acc964abb3e4c4be1ca8977388bd5d3
https://doi.org/10.1006/taap.1997.8343
https://doi.org/10.1006/taap.1997.8343
Publikováno v:
Fundamental and Applied Toxicology. 40:264-271
Nitroaromatic musks, including musk ketone (MK; 2,6-dimethyl-3,5-dinitro-4-t-butylacetophenone), are chemicals used as perfume ingredients in household products, cosmetics, and toiletries. Musk xylene (MX; 1,3,5-trinitro-2-t-butylxylene), another nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a537ce1f02de38cbf376942f35dab1
https://doi.org/10.1006/faat.1997.2395
https://doi.org/10.1006/faat.1997.2395
Publikováno v:
Molecular Carcinogenesis. 20:308-316
Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX is also capable of inducing cytochrome P450 enzymes in a manner similar to that of phenobar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f71ed497fa89b4d06f98e2623c2642e
https://doi.org/10.1002/(sici)1098-2744(199711)20:3<308::aid-mc7>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199711)20:3<308::aid-mc7>3.0.co
Publikováno v:
Toxicology and Applied Pharmacology. 142:169-177
Musk xylene (MX) (1,3,5-trinitro-2-t-butylxylene) is a nitromusk perfume ingredient that although uniformly negative in a battery of genotoxicity tests, produces a high incidence of liver tumors in mice. The purpose of this work was to characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c06ef88797673c8e5f1be007e8841ec
https://doi.org/10.1006/taap.1996.7927
https://doi.org/10.1006/taap.1996.7927
Publikováno v:
Toxicological Sciences. 23:562-568
d-Limonene Induced Hyaline Droplet Nephropathy in α2u-Globulin Transgenic Mice. Lehmian-McKeeman, L. D., and Caudill, D. (1994). Fundam. Appl. Toxicol. 23, 562-568. d-Limonene is a hyaline droplet inducing agent and produces nephrotoxicity in male r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87eb03bb9359d3071e8ccdee9409f71
https://doi.org/10.1093/toxsci/23.4.562
https://doi.org/10.1093/toxsci/23.4.562
Autor:
Ray Takigiku, Douglas Caudill, Lois D. Lehman-McKeeman, Monica L. Fey, Cynthia L. Eddy, Pedro Antonio Rodriguez
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 563:271-282
A Perkin Elmer 3920 gas chromatograph, equipped with a versatile inlet system (i.e. an injector/trap), was interfaced to a radioactivity detector and a mass-selective detector (H/P 5970B) to identify 14C-labeled compounds. The use of a pre-trap as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f6bc9e0b9903ac1b59dd0f91762294
https://doi.org/10.1016/0378-4347(91)80034-a
https://doi.org/10.1016/0378-4347(91)80034-a
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 30(5)
Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species differences in toxicity are metabolism-dependent, with injury resulting from the cytochrome P450-mediated formation of coumarin 3,4-epoxide (CE). In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126db2bf00acb8f264db78c1ef12fb35
https://pubmed.ncbi.nlm.nih.gov/11950775
https://pubmed.ncbi.nlm.nih.gov/11950775
Autor:
Robin Pearce, Andrew Parkinson, Ajay Madan, Jeffrey D. Vassallo, Lois D. Lehman-McKeeman, Douglas Caudill
Publikováno v:
Toxicology letters. 111(1-2)
The purpose of the present work was to characterize the effect of musk xylene (MX) and musk ketone (MK) treatment on rat hepatic cytochrome P450 enzymes. Male F344 rats were dosed orally with MX (10, 50 or 200 mg/kg) or MK (20, 100 or 200 mg/kg) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bf83d884840cdead8f4db620a59810
https://pubmed.ncbi.nlm.nih.gov/10630706
https://pubmed.ncbi.nlm.nih.gov/10630706