Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Douglas C. Wolf"'
Autor:
Amber Goetz, Natalia Ryan, Alaina Sauve-Ciencewicki, Caleb C. Lord, Gina M. Hilton, Douglas C. Wolf
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The rodent cancer bioassays are conducted for agrochemical safety assessment yet they often do not inform regulatory decision-making. As part of a collaborative effort, the Rethinking Carcinogenicity Assessment for Agrochemicals Project (ReCAAP) deve
Externí odkaz:
https://doaj.org/article/5dcd1988a38341df96d2ea6a672e5a66
Autor:
Douglas C. Wolf, April N. Naegeli, Page C. Moore, Jud C. Janak, Margaux M. Crabtree, Mingyang Shan, Theresa M. Hunter, Angelina Sontag, Raymond K. Cross
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 799-809 (2023)
Background and Aims: Fecal urgency is a common symptom of Ulcerative Colitis (UC). We explored the association between changes in fecal urgency for patient characteristics and evaluated the association between change in treatment and change in fecal
Externí odkaz:
https://doaj.org/article/d0559694a29d41378ca38f9362f5054c
Autor:
William J Sandborn, Séverine Vermeire, Laurent Peyrin-Biroulet, Marla C Dubinsky, Julian Panes, Andres Yarur, Timothy Ritter, Filip Baert, Stefan Schreiber, Sheldon Sloan, Fabio Cataldi, Kevin Shan, Christopher J Rabbat, Michael Chiorean, Douglas C Wolf, Bruce E Sands, Geert D'Haens, Silvio Danese, Martina Goetsch, Brian G Feagan
Publikováno v:
The Lancet, 401(10383), 1159-1171. Elsevier Limited
BACKGROUND: Etrasimod, a once-daily, oral, sphingosine 1-phosphate (S1P) receptor modulator that selectively activates S1P receptor subtypes 1, 4, and 5, with no detectable activity on S1P2,3, is in development for the treatment of immune-mediated di
Autor:
Douglas C Wolf, Yadvinder Bhuller, Rhian Cope, Marco Corvaro, Richard A Currie, John Doe, Adriana Doi, Gina Hilton, Jyotigna Mehta, David Saltmiras, Fiona Sewell, Maria Trainer, Sandrine E Déglin
Publikováno v:
Pest Management Science. 78:5049-5056
The present agrochemical safety evaluation paradigm is long-standing and anchored in well-established testing and evaluation procedures. However, it does not meet the present-day challenges of rapidly growing populations, food insecurity, and pressur
Autor:
Bruce A. C. Cree, Silvio Danese, Douglas C. Wolf, Olga Alekseeva, Lorna Charles, AnnKatrin Petersen, James K. Sheffield, Chun-Yen Cheng, Jon V. Riolo, Diego Silva, Fred D. Lublin, David T. Rubin, Jeffrey A. Cohen
Publikováno v:
Tuesday, April 25.
Autor:
Douglas C. Wolf, Carol Beevers, Pratibha Mistry, Rejin Salimraj, Richard A. Currie, Elizabeth F. McInnes, Paul Parsons
Publikováno v:
Toxicology Letters. 351:18-27
The aim of this study was to examine whether short term, repeat dose, rat studies provide sufficient information about potential carcinogenicity to enable predictions about the carcinogenic potential of agrochemicals to be made earlier in compound de
Autor:
Angelo Moretto, Penelope A. Fenner-Crisp, Samuel M. Cohen, Vicki L. Dellarco, John E. Doe, Alan R. Boobis, Timothy P. Pastoor, Jennifer Seed, Rita Schoeny, Douglas C. Wolf
Publikováno v:
Archives of Toxicology
The long running controversy about the relative merits of hazard-based versus risk-based approaches has been investigated. There are three levels of hazard codification: level 1 divides chemicals into dichotomous bands of hazardous and non-hazardous;
Autor:
Alex Charlton, Paul M. Hinderliter, Marie McGee Hargrove, Joanne Wallace, Lei Li, Samuel Constant, Douglas C. Wolf, Bob Parr-Dobrzanski
Publikováno v:
Applied In Vitro Toxicology. 7:50-60
Introduction: The United States Environmental Protection Agency (US EPA) has issued a directive to reduce mammalian studies to 30% by 2025. The application of new approach methodologies is being im...
Autor:
Angela Mujukian, Gregory J. Botwin, Rashmi Kumar, Brigid Boland, Michael Chiorean, Erica R. Cohen, David Fudman, Jason Hou, Caroline Hwang, Mark Lazarev, Donald F. Lum, Mark C. Mattar, Ryan McConnell, Arthur Ostrov, Nimisha Parekh, Douglas C. Wolf, Younis Ziad, Bradley Morganstern, Arash Horizon, Keren L. Appel, Swamy Venuturupalli, Daniel J. Wallace, Sarah Glover, Christina Ha, Gaurav Syal, Andrea Banty, Shervin Rabizadeh, Edward J. Feldman, Susie K. Lee, Theodore Stein, Nancy Sun, Min Wu, Joseph Ebinger, Susan Cheng, Gil Melmed, Dermot McGovern, Jonathan Braun
Publikováno v:
American Journal of Gastroenterology. 116:S453-S455
Autor:
Douglas C. Wolf, Remo Panaccione, Irina Blumenstein, Millie Long, Bincy Abraham, Anjali Jain, Arteid Memaj, Chun Wu, Vanessa Hobbs, Sarah Harris, James B. Canavan, Laurent Peyrin-Biroulet
Publikováno v:
American Journal of Gastroenterology. 117:e514-e515